Reviewed, UniProtKB/Swiss-Prot Q6P093 (ADCL2_HUMAN)

Names and origin

Protein names

Recommended name:
    Arylacetamide deacetylase-like 2
    EC=3.1.1.-

Gene names

Name:

AADACL2

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	401 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Subcellular location	Secreted.
Sequence similarities	Belongs to the 'GDXG' lipolytic enzyme family.

Ontologies

Keywords
Cellular component	Secreted
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Signal
Molecular function	Hydrolase
Gene Ontology (GO)
None. [Check GOA]

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q6P093-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q6P093-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-213: Missing.

Notes: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view
Molecule processing
	Signal peptide	1 – 18	18	Potential
	Chain	19 – 401	383	Arylacetamide deacetylase-like 2
Sites
	Active site	111	1	Potential
	Active site	189	1	Potential
Amino acid modifications
	Disulfide bond	116 ↔ 338		By similarity
Natural variations
	Alternative sequence	1 – 213	213	Missing in isoform 2.
	Natural variant	186	1	A → S: dbSNP rs1972977.
	Natural variant	343	1	L → I: dbSNP rs1052562.
Experimental info
	Sequence conflict	121	1	E → K in AAH65724. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified January 15, 2008. Version 2. Checksum: 8397A8D2DFA4C7FA	FASTA	401	46,100
	10 20 30 40 50 60 MGLKALCLGL LCVLFVSHFY TPMPDNIEES WKIMALDAIA KTCTFTAMCF ENMRIMRYEE 70 80 90 100 110 120 FISMIFRLDY TQPLSDEYIT VTDTTFVDIP VRLYLPKRKS ETRRRAVIYF HGGGFCFGSS 130 140 150 160 170 180 EQRAFDFLNR WTANTLDAVV VGVDYRLAPQ HHFPAQFEDG LAAVKFFLLE KILTKYGVDP 190 200 210 220 230 240 TRICIAGDSS GGNLATAVTQ QVQNDAEIKH KIKMQVLLYP GLQITDSYLP SHRENEHGIV 250 260 270 280 290 300 LTRDVAIKLV SLYFTKDEAL PWAMRRNQHM PLESRHLFKF VNWSILLPEK YRKDYVYTEP 310 320 330 340 350 360 ILGGLSYSLP GLTDSRALPL LANDSQLQNL PLTYILTCQH DLLRDDGLMY VTRLRNVGVQ 370 380 390 400 VVHEHIEDGI HGALSFMTSP FYLRLGLRIR DMYVSWLDKN L
	Isoform 2 [UniParc]. Checksum: 488CA6F31CCFA77B		188	21,869
	10 20 30 40 50 60 MQVLLYPGLQ ITDSYLPSHR ENEHGIVLTR DVAIKLVSLY FTKDEALPWA MRRNQHMPLE 70 80 90 100 110 120 SRHLFKFVNW SILLPEKYRK DYVYTEPILG GLSYSLPGLT DSRALPLLAN DSQLQNLPLT 130 140 150 160 170 180 YILTCQHDLL RDDGLMYVTR LRNVGVQVVH EHIEDGIHGA LSFMTSPFYL RLGLRIRDMY VSWLDKNL

References

[1]	The German cDNA consortium Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Adipose tissue.
[2]	"The DNA sequence, annotation and analysis of human chromosome 3." Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J. , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A. Nature 440:1194-1198(2006) [PubMed: 16641997] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT SER-186. Tissue: Placenta.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BX647585 mRNA. Translation: CAI46075.1. AC069067 Genomic DNA. No translation available. BC065724 mRNA. Translation: AAH65724.1. Different initiation.
RefSeq	NP_997248.1.
UniGene	Hs.144710
3D structure databases
ModBase	Search...
Genome annotation databases
Ensembl	ENSG00000197953. Homo sapiens. [Contig view]
GeneID	344752.
KEGG	hsa:344752.
Organism-specific databases
HGNC	HGNC:24427. AADACL2.
PharmGKB	PA142670463.
GenAtlas	Search...
GeneCards	Search...
Phylogenomic databases
HOGENOM	Q6P093.
HOVERGEN	Q6P093.
Gene expression databases
ArrayExpress	Q6P093.
CleanEx	HS_AADACL2.
Family and domain databases
InterPro	IPR013094. AB_hydrolase_3. IPR002168. Lipase_GDXG_AS. [Graphical view]
Pfam	PF07859. Abhydrolase_3. 1 hit. [Graphical view]
PROSITE	PS01173. LIPASE_GDXG_HIS. False negative. PS01174. LIPASE_GDXG_SER. 1 hit. [Graphical view]
ProDom	Q6P093. [Graphical view] [Entries sharing at least one domain]
BLOCKS	Search...
Other Resources
ProtoNet	Search...

Entry information

Entry name

ADCL2_HUMAN

Accession

Primary (citable) accession number: Q6P093
Secondary accession number(s): Q5HYJ4

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	January 15, 2008
Last modified:	July 22, 2008
This is version 30 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)