Reviewed, UniProtKB/Swiss-Prot Q6S8J7 (A26A1_HUMAN)

Names and origin

Protein names

Recommended name:
    ANKRD26-like family A member 1
Alternative name(s):
    Prostate, ovary, testis-expressed protein on chromosome 8
      Short name=POTE-8

Gene names

Name:	A26A1
Synonyms:	POTE8

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	498 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Sequence similarities

Belongs to the POTE family. Contains 5 ANK repeats.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing
Domain	ANK repeat Coiled coil Repeat
Gene Ontology (GO)
None. [Check GOA]

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q6S8J7-1)

Also known as: A;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q6S8J7-2)

Also known as: B;

The sequence of this isoform differs from the canonical sequence as follows:
     233-278: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view
Molecule processing
	Chain	1 – 498	498	ANKRD26-like family A member 1
Regions
	Repeat	98 – 127	30	ANK 1
	Repeat	131 – 160	30	ANK 2
	Repeat	164 – 193	30	ANK 3
	Repeat	197 – 226	30	ANK 4
	Repeat	230 – 259	30	ANK 5
	Coiled coil	469 – 497	29	Potential
	Compositional bias	28 – 35	8	Cys-rich
Natural variations
	Alternative sequence	233 – 278	46	Missing in isoform 2.

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (A) [UniParc]. Last modified July 5, 2004. Version 1. Checksum: 758C1C7BD6F10395	FASTA	498	56,166
	10 20 30 40 50 60 MVAEVSPKLA ASPMKKPFGF RGKMGKWCCC CFPCCRGSGK NNMGAWRDHD DSAFTEPRYH 70 80 90 100 110 120 VRREDLGKLH RAAWWGEVPR ADLIVMLRGP GINKRDKKKR TALHLACANG NSEVVSLLLD 130 140 150 160 170 180 RQCQLHVFDS KKRTALIKAV QCQEDECALM LLQHGTDPNL PDMYGNTALH YAVYNEDKLM 190 200 210 220 230 240 AKTLLLYGAD IESKNKGGLT PLLLAVHGQK QRMVKFLIKK KANLNALDRF GRTALILAVR 250 260 270 280 290 300 CGSASIVSLL LQQNIDVFSQ DVFGQTAEDY AVSSHHSIIC QLLSDYKENQ MPNNSSGNSN 310 320 330 340 350 360 PEQDLKLTSE EEPQRLKGSE NSQHEKVTQE PDINKDCDRE VEEEMQKHGS NNVGLSENLT 370 380 390 400 410 420 DGAAAGNGDG GLVPQRKSRK HENQQFPNTE IEEYHRPEKK SNEKNKVKSQ IHSVDNLDDI 430 440 450 460 470 480 TWPSEIASED YDLLFSNYET FTLLIEQLKM DFNDSASLSK IQDAVISEEH LLELKNSHYE 490 QLTVEVEQME NMVHVLQK
	Isoform 2 (B) [UniParc]. Checksum: 498C03F7E9278F8E		452	51,278
	10 20 30 40 50 60 MVAEVSPKLA ASPMKKPFGF RGKMGKWCCC CFPCCRGSGK NNMGAWRDHD DSAFTEPRYH 70 80 90 100 110 120 VRREDLGKLH RAAWWGEVPR ADLIVMLRGP GINKRDKKKR TALHLACANG NSEVVSLLLD 130 140 150 160 170 180 RQCQLHVFDS KKRTALIKAV QCQEDECALM LLQHGTDPNL PDMYGNTALH YAVYNEDKLM 190 200 210 220 230 240 AKTLLLYGAD IESKNKGGLT PLLLAVHGQK QRMVKFLIKK KANLNALDRF GRICQLLSDY 250 260 270 280 290 300 KENQMPNNSS GNSNPEQDLK LTSEEEPQRL KGSENSQHEK VTQEPDINKD CDREVEEEMQ 310 320 330 340 350 360 KHGSNNVGLS ENLTDGAAAG NGDGGLVPQR KSRKHENQQF PNTEIEEYHR PEKKSNEKNK 370 380 390 400 410 420 VKSQIHSVDN LDDITWPSEI ASEDYDLLFS NYETFTLLIE QLKMDFNDSA SLSKIQDAVI 430 440 450 SEEHLLELKN SHYEQLTVEV EQMENMVHVL QK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Five POTE paralogs and their splice variants are expressed in human prostate and encode proteins of different lengths." Bera T.K., Huynh N., Maeda H., Sathyanarayana B.K., Lee B., Pastan I. Gene 337:45-53(2004) [PubMed: 15276201] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2). Tissue: Prostate.
[2]	"DNA sequence and analysis of human chromosome 8." Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S., Asakawa T. , Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P., Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H., Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B., O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N., Lander E.S. Nature 439:331-335(2006) [PubMed: 16421571] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AY462869 mRNA. Translation: AAS58863.1. AY462870 mRNA. Translation: AAS58864.1. AC022616 Genomic DNA. No translation available.
RefSeq	NP_001002920.1. NP_001005365.2.
UniGene	Hs.531579
3D structure databases
ModBase	Search...
Genome annotation databases
Ensembl	ENSG00000188877. Homo sapiens. [Contig view]
GeneID	340441.
KEGG	hsa:340441.
Organism-specific databases
H-InvDB	HIX0034320.
HGNC	HGNC:33893. A26A1.
MIM	608915. gene.
GenAtlas	Search...
GeneCards	Search...
Phylogenomic databases
HOGENOM	Q6S8J7.
HOVERGEN	Q6S8J7.
Gene expression databases
ArrayExpress	Q6S8J7.
CleanEx	HS_A26A1.
Family and domain databases
InterPro	IPR002110. ANK. [Graphical view]
Gene3D	G3DSA:1.25.40.20. ANK. 1 hit.
Pfam	PF00023. Ank. 5 hits. [Graphical view]
PRINTS	PR01415. ANKYRIN.
SMART	SM00248. ANK. 6 hits. [Graphical view]
PROSITE	PS50297. ANK_REP_REGION. 1 hit. PS50088. ANK_REPEAT. 4 hits. [Graphical view]
ProDom	Q6S8J7. [Graphical view] [Entries sharing at least one domain]
BLOCKS	Search...
Other Resources
LinkHub	Q6S8J7.
SOURCE	Search...
ProtoNet	Search...

Entry information

Entry name

A26A1_HUMAN

Accession

Primary (citable) accession number: Q6S8J7
Secondary accession number(s): A6ND17, A6ND71, Q6S8J6

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 23, 2004
Last sequence update:	July 5, 2004
Last modified:	July 22, 2008
This is version 33 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)