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Reviewed, UniProtKB/Swiss-Prot Q6W3F4 (AA2BR_CANFA)

Last modified September 2, 2008. Version 29. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Adenosine receptor A2b
Gene names
Name: ADORA2B
OrganismCanis familiaris (Dog)
Taxonomic identifier9615 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Carnivora › Caniformia › Canidae › Canis

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Protein attributes

Sequence length332 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at transcript level.

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General annotation (Comments)

Function

Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase By similarity.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

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Ontologies

Keywords

   Cellular componentCell membrane
Membrane
   DomainTransmembrane
   Molecular functionG-protein coupled receptor
Receptor
Transducer
   PTMGlycoprotein
Lipoprotein
Palmitate

Gene Ontology (GO)

None. [Check GOA]

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical view

Molecule processing

Chain1 – 332332Adenosine receptor A2b

Regions

Topological domain1 – 88Extracellular Potential
Transmembrane9 – 31231 Potential
Topological domain32 – 4413Cytoplasmic Potential
Transmembrane45 – 67232 Potential
Topological domain68 – 7811Extracellular Potential
Transmembrane79 – 101233 Potential
Topological domain102 – 12120Cytoplasmic Potential
Transmembrane122 – 144234 Potential
Topological domain145 – 17733Extracellular Potential
Transmembrane178 – 202255 Potential
Topological domain203 – 23432Cytoplasmic Potential
Transmembrane235 – 258246 Potential
Topological domain259 – 2668Extracellular Potential
Transmembrane267 – 290247 Potential
Topological domain291 – 33242Cytoplasmic Potential

Amino acid modifications

Lipidation3101S-palmitoyl cysteine Potential
Glycosylation1521N-linked (GlcNAc...) Potential
Glycosylation1621N-linked (GlcNAc...) Potential
Disulfide bond78 ↔ 170 By similarity

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Sequences

Sequence LengthMass (Da)Tools
Q6W3F4-1 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: 627BCB21C14B443C

FASTA33236,387
        10         20         30         40         50         60 
MQLETQDALY VALELAIAAL SVAGNVLVCA AVGTSSALQT PTNYFLVSLA AADVAVGLFA 

        70         80         90        100        110        120 
IPFAITISLG FCTDFHSCLF LACFVLVLTQ SSIFSLLAVA VDRYLAIRVP LRYKSLVTGT 

       130        140        150        160        170        180 
RARGVIAVLW VLAFGIGLTP FLGWNSKDSA TNCTEPWDGT TNESCCLVKC LFENVVPMSY 

       190        200        210        220        230        240 
MVYFNFFGCV LPPLLIMLVI YIKIFMVACK QLQRTELVDH SRTVIQREIH AAKSLAMIVG 

       250        260        270        280        290        300 
IFALCWLPVH AINCVTLFQP ARAKDKPKWA MNMAILLSHA SSVVNPIVYA YRNRDFRYTF 

       310        320        330 
HKIISRYVLC QTDVLKSGNG QAGTQSALDV GL

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References

[1]"Reduction in infarct size by CPX and the renal modulating agent BG 9928: evidence for involvement of A2B adenosine receptors."
Auchampach J.A., Jin X., Wang J., Moore J., Wan T.C., Keckler L., Ge Z.-D., Smits G., Whalley E., Ticho B., Gross G.J.
Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].

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Cross-references

Sequence databases

AY313204 mRNA. Translation: AAQ82905.1.
RefSeqNP_001002944.1.
UniGeneCfa.112

3D structure databases

ModBaseSearch...

Protein family/group databases

GPCRDBSearch...

Genome annotation databases

EnsemblENSCAFG00000018079. Canis familiaris. [Contig view]
GeneID403410.
KEGGcfa:403410.

Phylogenomic databases

HOVERGENQ6W3F4.

Family and domain databases

InterProIPR001435. Adeno_A2B_rcpt.
IPR001634. Adenosn_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_supfam.
[Graphical view]
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR00554. ADENOSINA2BR.
PR00424. ADENOSINER.
PR00237. GPCRRHODOPSN.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProDomQ6W3F4.
[Graphical view] [Entries sharing at least one domain]
BLOCKSSearch...

Other Resources

ProtoNetSearch...

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Entry information

Entry nameAA2BR_CANFA
AccessionPrimary (citable) accession number: Q6W3F4
Entry history
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: July 5, 2004
Last modified: September 2, 2008
This is version 29 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

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Relevant documents

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents