Reviewed, UniProtKB/Swiss-Prot Q6XD76 (ASCL4_HUMAN)

Names and origin

Protein names

Recommended name:
    Achaete-scute homolog 4
Alternative name(s):
    Achaete-scute-like protein 4

Gene names

Name:	ASCL4
Synonyms:	HASH4

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	172 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Could be a transcriptional regulator involved in skin development.
Subcellular location	NucleusBy similarity.
Tissue specificity	Expressed in skin. 7-fold higher expression in fetal skin than in adult skin. Weak expression also detected in fetal lung, aorta and brain, and in adult stomach, kidney, ovary and breast.
Sequence similarities	Contains 1 basic helix-loop-helix (bHLH) domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Ligand	DNA-binding
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view
Molecule processing
	Chain	1 – 172	172	Achaete-scute homolog 4
Regions
	Domain	86 – 125	40	Helix-loop-helix motif
	DNA binding	75 – 85	11	Basic motif

Sequences

	Sequence		Length	Mass (Da)
	Q6XD76-1 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: 94686681C4E64FB1	FASTA	172	19,253
	10 20 30 40 50 60 METRKPAERL ALPYSLRTAP LGVPGTLPGL PRRDPLRVAL RLDAACWEWA RSGCARGWQY 70 80 90 100 110 120 LPVPLDSAFE PAFLRKRNER ERQRVRCVNE GYARLRDHLP RELADKRLSK VETLRAAIDY 130 140 150 160 170 IKHLQELLER QAWGLEGAAG AVPQRRAECN SDGESKASSA PSPSSEPEEG GS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Hash4, a novel human achaete-scute homologue found in fetal skin." Jonsson M., Bjoerntorp Mark E., Brantsing C., Brandner J.M., Lindahl A., Asp J. Genomics 84:859-866(2004) [PubMed: 15475265] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY. Tissue: Skin.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]	"Exhaustive identification of human class II basic helix-loop-helix proteins by virtual library screening." McLellan A.S., Langlands K., Kealey T. Mech. Dev. 119:S285-S291(2002) [PubMed: 14516699] [Abstract] Cited for: IDENTIFICATION.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AY238895 mRNA. Translation: AAP69222.1. BC128211 mRNA. Translation: AAI28212.1. BC128212 mRNA. Translation: AAI28213.1. BK000275 mRNA. Translation: DAA01055.1. Different initiation.
RefSeq	NP_982260.1.
UniGene	Hs.149910
3D structure databases
ModBase	Search...
Genome annotation databases
Ensembl	ENSG00000187855. Homo sapiens. [Contig view]
GeneID	121549.
KEGG	hsa:121549.
Organism-specific databases
HGNC	HGNC:24311. ASCL4.
MIM	609155. gene.
PharmGKB	PA134869300.
GenAtlas	Search...
GeneCards	Search...
Phylogenomic databases
HOVERGEN	Q6XD76.
Gene expression databases
ArrayExpress	Q6XD76.
CleanEx	HS_ASCL4.
Family and domain databases
InterPro	IPR015660. ASH. IPR001092. HLH_basic. IPR011598. HLH_DNA_bd. [Graphical view]
Gene3D	G3DSA:4.10.280.10. HLH_DNA_bd. 1 hit.
PANTHER	PTHR13935. ASH. 1 hit.
Pfam	PF00010. HLH. 1 hit. [Graphical view]
SMART	SM00353. HLH. 1 hit. [Graphical view]
PROSITE	PS50888. HLH. 1 hit. [Graphical view]
ProDom	Q6XD76. [Graphical view] [Entries sharing at least one domain]
BLOCKS	Search...
Other Resources
SOURCE	Search...
ProtoNet	Search...

Entry information

Entry name

ASCL4_HUMAN

Accession

Primary (citable) accession number: Q6XD76
Secondary accession number(s): Q7RTS2

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	July 5, 2004
Last modified:	July 22, 2008
This is version 32 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)