Reviewed, UniProtKB/Swiss-Prot Q709F0 (ACD11_HUMAN)

Names and origin

Protein names

Recommended name:
    Acyl-CoA dehydrogenase family member 11
      Short name=ACAD-11

Gene names

Name:

ACAD11

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	780 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Sequence similarities

Belongs to the acyl-CoA dehydrogenase family.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing Polymorphism
PTM	Phosphoprotein
Gene Ontology (GO)
Cellular component	peroxisome Inferred from sequence or structural similarity. Source: HGNC
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q709F0-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q709F0-2)

The sequence of this isoform differs from the canonical sequence as follows:
     564-667: Missing.

Isoform 3 (identifier: Q709F0-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-120: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view
Molecule processing
	Chain	1 – 780	780	Acyl-CoA dehydrogenase family member 11
Amino acid modifications
	Modified residue	324	1	Phosphotyrosine By similarity
Natural variations
	Alternative sequence	1 – 120	120	Missing in isoform 3.
	Alternative sequence	564 – 667	104	Missing in isoform 2.
	Natural variant	157	1	R → H: dbSNP rs821572.
	Natural variant	362	1	V → L: dbSNP rs6776576.
Experimental info
	Sequence conflict	414	1	K → T in CAH56354. Ref.2
	Sequence conflict	549	1	I → V in CAE55233. Ref.1
	Sequence conflict	549	1	I → V in BAB14158. Ref.3
	Sequence conflict	562	1	S → SRLT in CAH56228. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified October 31, 2006. Version 2. Checksum: 407DAE4DC6563070	FASTA	780	87,283
	10 20 30 40 50 60 MKPGATGESD LAEVLPQHKF DSKSLEAYLN QHLSGFGAER EATLTIAQYR AGKSNPTFYL 70 80 90 100 110 120 QKGFQTYVLR KKPPGSLLPK AHQIDREFKV QKALFSIGFP VPKPILYCSD TSVIGTEFYV 130 140 150 160 170 180 MEHVQGRIFR DLTIPGLSPA ERSAIYVATV ETLAQLRSLN IQSLQLEGYG IGAGYCKRQV 190 200 210 220 230 240 STWTKQYQAA AHQDIPAMQQ LSEWLMKNLP DNDNEENLIH GDFRLDNIVF HPKECRVIAV 250 260 270 280 290 300 LDWELSTIGH PLSDLAHFSL FYFWPRTVPM INQGSYSENS GIPSMEELIS IYCRCRGINS 310 320 330 340 350 360 ILPNWNFFLA LSYFKMAGIA QGVYSRYLLG NNSSEDSFLF ANIVQPLAET GLQLSKRTFS 370 380 390 400 410 420 TVLPQIDTTG QLFVQTRKGQ EVLIKVKHFM KQHILPAEKE VTEFYVQNEN SVDKWGKPLV 430 440 450 460 470 480 IDKLKEMAKV EGLWNLFLPA VSGLSHVDYA LIAEETGKCF FAPDVFNCQA PDTGNMEVLH 490 500 510 520 530 540 LYGSEEQKKQ WLEPLLQGNI TSCFCMTEPD VASSDATNIE CSIQRDEDSY VINGKKWWSS 550 560 570 580 590 600 GAGNPKCKIA IVLGRTQNTS LSRHKQHSMI LVPMNTPGVK IIRPLSVFGY TDNFHGGHFE 610 620 630 640 650 660 IHFNQVRVPA TNLILGEGRG FEISQGRLGP GRIHHCMRTV GLAERALQIM CERATQRIAF 670 680 690 700 710 720 KKKLYAHEVV AHWIAESRIA IEKIRLLTLK AAHSMDTLGS AGAKKEIAMI KVAAPRAVSK 730 740 750 760 770 780 IVDWAIQVCG GAGVSQDYPL ANMYAITRVL RLADGPDEVH LSAIATMELR DQAKRLTAKI
	Isoform 2 [UniParc]. Checksum: 7014E38FD5C21E8E		676	75,517
	10 20 30 40 50 60 MKPGATGESD LAEVLPQHKF DSKSLEAYLN QHLSGFGAER EATLTIAQYR AGKSNPTFYL 70 80 90 100 110 120 QKGFQTYVLR KKPPGSLLPK AHQIDREFKV QKALFSIGFP VPKPILYCSD TSVIGTEFYV 130 140 150 160 170 180 MEHVQGRIFR DLTIPGLSPA ERSAIYVATV ETLAQLRSLN IQSLQLEGYG IGAGYCKRQV 190 200 210 220 230 240 STWTKQYQAA AHQDIPAMQQ LSEWLMKNLP DNDNEENLIH GDFRLDNIVF HPKECRVIAV 250 260 270 280 290 300 LDWELSTIGH PLSDLAHFSL FYFWPRTVPM INQGSYSENS GIPSMEELIS IYCRCRGINS 310 320 330 340 350 360 ILPNWNFFLA LSYFKMAGIA QGVYSRYLLG NNSSEDSFLF ANIVQPLAET GLQLSKRTFS 370 380 390 400 410 420 TVLPQIDTTG QLFVQTRKGQ EVLIKVKHFM KQHILPAEKE VTEFYVQNEN SVDKWGKPLV 430 440 450 460 470 480 IDKLKEMAKV EGLWNLFLPA VSGLSHVDYA LIAEETGKCF FAPDVFNCQA PDTGNMEVLH 490 500 510 520 530 540 LYGSEEQKKQ WLEPLLQGNI TSCFCMTEPD VASSDATNIE CSIQRDEDSY VINGKKWWSS 550 560 570 580 590 600 GAGNPKCKIA IVLGRTQNTS LSREVVAHWI AESRIAIEKI RLLTLKAAHS MDTLGSAGAK 610 620 630 640 650 660 KEIAMIKVAA PRAVSKIVDW AIQVCGGAGV SQDYPLANMY AITRVLRLAD GPDEVHLSAI 670 ATMELRDQAK RLTAKI
	Isoform 3 [UniParc]. Checksum: 46963EAAC8967AF6		660	73,920
	10 20 30 40 50 60 MEHVQGRIFR DLTIPGLSPA ERSAIYVATV ETLAQLRSLN IQSLQLEGYG IGAGYCKRQV 70 80 90 100 110 120 STWTKQYQAA AHQDIPAMQQ LSEWLMKNLP DNDNEENLIH GDFRLDNIVF HPKECRVIAV 130 140 150 160 170 180 LDWELSTIGH PLSDLAHFSL FYFWPRTVPM INQGSYSENS GIPSMEELIS IYCRCRGINS 190 200 210 220 230 240 ILPNWNFFLA LSYFKMAGIA QGVYSRYLLG NNSSEDSFLF ANIVQPLAET GLQLSKRTFS 250 260 270 280 290 300 TVLPQIDTTG QLFVQTRKGQ EVLIKVKHFM KQHILPAEKE VTEFYVQNEN SVDKWGKPLV 310 320 330 340 350 360 IDKLKEMAKV EGLWNLFLPA VSGLSHVDYA LIAEETGKCF FAPDVFNCQA PDTGNMEVLH 370 380 390 400 410 420 LYGSEEQKKQ WLEPLLQGNI TSCFCMTEPD VASSDATNIE CSIQRDEDSY VINGKKWWSS 430 440 450 460 470 480 GAGNPKCKIA IVLGRTQNTS LSRHKQHSMI LVPMNTPGVK IIRPLSVFGY TDNFHGGHFE 490 500 510 520 530 540 IHFNQVRVPA TNLILGEGRG FEISQGRLGP GRIHHCMRTV GLAERALQIM CERATQRIAF 550 560 570 580 590 600 KKKLYAHEVV AHWIAESRIA IEKIRLLTLK AAHSMDTLGS AGAKKEIAMI KVAAPRAVSK 610 620 630 640 650 660 IVDWAIQVCG GAGVSQDYPL ANMYAITRVL RLADGPDEVH LSAIATMELR DQAKRLTAKI

References

[1]	"Presence of an acyl-CoA dehydrogenase in mammalian peroxisomes ?" Mahieu V., Van Veldhoven P.P. Submitted (NOV-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT HIS-157.
[2]	The German cDNA consortium Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 35-780 (ISOFORM 1), VARIANT HIS-157. Tissue: Lymph node and Stomach.
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-563 (ISOFORM 3), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 343-780 (ISOFORM 1), VARIANT HIS-157. Tissue: Tongue.
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT HIS-157. Tissue: Cervix.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AJ608287 mRNA. Translation: CAE55233.1. AL833721 mRNA. Translation: CAH56228.1. AL832873 mRNA. Translation: CAH56354.1. AK022654 mRNA. Translation: BAB14158.1. Different initiation. AK131265 mRNA. Translation: BAD18443.1. BC019607 mRNA. Translation: AAH19607.2. BC125204 mRNA. Translation: AAI25205.1.
RefSeq	NP_115545.3.
UniGene	Hs.441378
3D structure databases
ModBase	Search...
PTM databases
PhosphoSite	Q709F0.
Genome annotation databases
Ensembl	ENSG00000113971. Homo sapiens. [Contig view]
GeneID	84129.
KEGG	hsa:84129.
NMPDR	fig|9606.3.peg.23204.
Organism-specific databases
HGNC	HGNC:30211. ACAD11.
PharmGKB	PA142672658.
GenAtlas	Search...
GeneCards	Search...
Phylogenomic databases
HOVERGEN	Q709F0.
Gene expression databases
ArrayExpress	Q709F0.
CleanEx	HS_ACAD11.
GermOnline	ENSG00000113971. Homo sapiens.
Family and domain databases
InterPro	IPR006091. Acyl-CoA_DHase/Oxase_M. IPR006090. Acyl-CoA_Oxase/DHase_1. IPR013786. AcylCoA_DH/ox_N. IPR013764. AcylCoA_oxidase/DH_1/2_C. IPR002575. APH_trans. [Graphical view]
Gene3D	G3DSA:2.40.110.10. Acyl_CoA_DH/ox_M. 1 hit. G3DSA:1.10.540.10. AcylCoA_DH/ox_N. 1 hit. G3DSA:1.20.140.10. AcylCoA_DH_1/2_C. 1 hit.
Pfam	PF00441. Acyl-CoA_dh_1. 1 hit. PF02770. Acyl-CoA_dh_M. 1 hit. PF01636. APH. 1 hit. [Graphical view]
ProDom	Q709F0. [Graphical view] [Entries sharing at least one domain]
BLOCKS	Search...
Other Resources
ProtoNet	Search...

Entry information

Entry name

ACD11_HUMAN

Accession

Primary (citable) accession number: Q709F0
Secondary accession number(s): Q08AF0 , Q658N9, Q658Y2, Q6ZND2, Q8WUT6, Q9H9R3

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 31, 2006
Last sequence update:	October 31, 2006
Last modified:	July 22, 2008
This is version 44 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)