Skip Header

 
Contribute Send feedback

Reviewed, UniProtKB/Swiss-Prot Q7A057 (FDHL_STAAW)

Last modified September 2, 2008. Version 35. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Hide | Top

Names and origin

Protein namesRecommended name:
    Putative formate dehydrogenase MW2229
    EC=1.2.1.2
Gene names
Ordered Locus Names: MW2229
OrganismStaphylococcus aureus (strain MW2) [Complete proteome] [HAMAP]
Taxonomic identifier196620 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacillales › Staphylococcus

Hide | Top

Protein attributes

Sequence length984 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

Hide | Top

General annotation (Comments)

Catalytic activity

Formate + NAD(+) = CO(2) + NADH.

Cofactor

Binds 1 2Fe-2S cluster By similarity.

Binds 4 4Fe-4S clusters By similarity.

Molybdenum (molybdopterin) By similarity.

Sequence similarities

In the C-terminal section; belongs to the prokaryotic molybdopterin-containing oxidoreductase family.

Contains 1 2Fe-2S ferredoxin-type domain.

Contains 2 4Fe-4S ferredoxin-type domains.

Hide | Top

Ontologies

Keywords

   DomainRepeat
   Ligand2Fe-2S
4Fe-4S
Iron
Iron-sulfur
Metal-binding
Molybdenum
NAD
   Molecular functionOxidoreductase
   Technical termComplete proteome

Gene Ontology (GO)

None. [Check GOA]

Hide | Top

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical view

Molecule processing

Chain1 – 984984Putative formate dehydrogenase MW2229

Regions

Domain3 – 79772Fe-2S ferredoxin-type
Domain138 – 165284Fe-4S ferredoxin-type 1
Domain181 – 211314Fe-4S ferredoxin-type 2
Region252 – 984733Formate dehydrogenase

Sites

Metal binding371Iron-sulfur 1 (2Fe-2S) By similarity
Metal binding481Iron-sulfur 1 (2Fe-2S) By similarity
Metal binding511Iron-sulfur 1 (2Fe-2S) By similarity
Metal binding631Iron-sulfur 1 (2Fe-2S) By similarity
Metal binding951Iron-sulfur 2 (4Fe-4S); via tele nitrogen By similarity
Metal binding991Iron-sulfur 2 (4Fe-4S) By similarity
Metal binding1021Iron-sulfur 2 (4Fe-4S) By similarity
Metal binding1091Iron-sulfur 2 (4Fe-4S) By similarity
Metal binding1471Iron-sulfur 3 (4Fe-4S) By similarity
Metal binding1501Iron-sulfur 3 (4Fe-4S) By similarity
Metal binding1531Iron-sulfur 3 (4Fe-4S) By similarity
Metal binding1571Iron-sulfur 4 (4Fe-4S) By similarity
Metal binding1901Iron-sulfur 4 (4Fe-4S) By similarity
Metal binding1931Iron-sulfur 4 (4Fe-4S) By similarity
Metal binding1961Iron-sulfur 4 (4Fe-4S) By similarity
Metal binding2001Iron-sulfur 3 (4Fe-4S) By similarity
Metal binding2641Iron-sulfur 5 (4Fe-4S) By similarity
Metal binding2671Iron-sulfur 5 (4Fe-4S) By similarity
Metal binding2711Iron-sulfur 5 (4Fe-4S) By similarity
Metal binding2991Iron-sulfur 5 (4Fe-4S) By similarity

Hide | Top

Sequences

Sequence LengthMass (Da)Tools
Q7A057-1 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: 79140674B6A0C1D3

FASTA984111,295
        10         20         30         40         50         60 
MQEHLVVTLD GKDYLVEPGT NLLEFIKSQD TFVPSICYNE SMGPIQTCDT CTVEIDGKIE 

        70         80         90        100        110        120 
RSCSTVIDRP MTVNTVNNDV KDAQKEALDR ILEKHMLYCT VCDYNNGDCE IHNTMDAWGL 

       130        140        150        160        170        180 
QHQTYEYKEK PYEKDYGPFY RYDPNQCILC GRCVEACQDI EVNETIRIDW DREHPRVIWD 

       190        200        210        220        230        240 
NDVPINESSC VSCGQCATVC PCNAMMEVNM EGNAGYMTDT EPGSLAAMID LTKKAEPGYG 

       250        260        270        280        290        300 
PLFAISDSEA EMRKERIKKT KTVCTYCGVG CSFEVWTKDR EILKVQPSHD SPANKIATCV 

       310        320        330        340        350        360 
KGKFSWGHIN SDQRLTKPLV RKNGEFHEVE WDEALNVIAD NFTSIKEKYG PDALSFISSS 

       370        380        390        400        410        420 
KATNEESYLM QKLARQVIGT NNVDNCSRYC QAPATKGLFR TVGHGGDSGS IEDLEKAAMS 

       430        440        450        460        470        480 
VLIGTNTAEA HPVIASRMKR AQKLFGQKIH VFDIRKHEMA ERADRFYQPK PGTDLAWLSA 

       490        500        510        520        530        540 
VTKYIIDHDL HDKAFIDEWV DDFDEYYKSL ETFTMAFAEE ATGIPESELI KFAEECAKAE 

       550        560        570        580        590        600 
SVVICWAMGI TQQDIGSDSS TAISNLLLVT GNYRRPGTGA YPLRGHNNVQ GCSDMGSMPD 

       610        620        630        640        650        660 
KITGYQSIEA DDIRAKFEKE YGVKLNPKAG KDNHEMVEGI HDGEVHSLYL YGEDTGIVDS 

       670        680        690        700        710        720 
NINFVQAAFE KLDFMVVQDE FLTFTATYAD VVLPASPSLE KDGTFTNTER RIQRLYQALE 

       730        740        750        760        770        780 
PLGDSKPDWK IFQAIANRLG FDWNYKHPSE IMDEVARLTP LYAGVSYDRL EGFNSLQWPV 

       790        800        810        820        830        840 
QPDGTDEPIL YLEGFNFDNG KAKLFPLSFD NYFKQDEIYD IHVNNGRLLE HFHEGNMTYQ 

       850        860        870        880        890        900 
TPMIKYKVPR AFVEISPELA EDRGIHEGAE VKLISETGEA VLQVHVTDRV KGKEIYIPLN 

       910        920        930        940        950        960 
NDAMENGDLG AINLLTNSDV DQYTDTPSYK RTSCRLEVIT KRGKSPLNPN NFRVNKKRHP 

       970        980 
QYSVQVQKKW ERSDYVFPGN QVDK

« Hide

Hide | Top

References

[1]"Genome and virulence determinants of high virulence community-acquired MRSA."
Baba T., Takeuchi F., Kuroda M., Yuzawa H., Aoki K., Oguchi A., Nagai Y., Iwama N., Asano K., Naimi T., Kuroda H., Cui L., Yamamoto K., Hiramatsu K.
Lancet 359:1819-1827(2002) [PubMed: 12044378] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Hide | Top

Cross-references

Sequence databases

BA000033 Genomic DNA. Translation: BAB96094.1.
RefSeqNP_647046.1.

3D structure databases

HSSPHSSP built from PDB template 1AA6 based on UniProtKB P07658.
ModBaseSearch...

Genome annotation databases

GeneID1004347.
GenomeReviewsGene locus MW2229 in contig BA000033_GR.
KEGGsam:MW2229.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMQ7A057.

Enzyme and pathway databases

BioCycSAUR196620:MW2229-MON.

Family and domain databases

InterProIPR001450. 4Fe4S_Fe_S_bd.
IPR009010. Asp_de-COase-like_fold.
IPR001041. Ferredoxin.
IPR006478. Formate_DHase_asu.
IPR006656. Mopterin_OxRdtase.
IPR006963. Mopterin_OxRdtase_Fe4S4.
IPR006655. Mopterin_OxRdtase_prok_CS.
IPR006657. MPT_dinuc_bd.
[Graphical view]
Gene3DG3DSA:2.40.40.20. Asp_decarboxylase-like_fold. 1 hit.
PfamPF00111. Fer2. 1 hit.
PF00037. Fer4. 2 hits.
PF04879. Molybdop_Fe4S4. 1 hit.
PF00384. Molybdopterin. 1 hit.
PF01568. Molydop_binding. 1 hit.
[Graphical view]
PRINTSPR00353. 4FE4SFRDOXIN.
TIGRFAMsTIGR01591. Fdh-alpha. 1 hit.
PROSITEPS51085. 2FE2S_FER_2. 1 hit.
PS00198. 4FE4S_FER_1. 1 hit.
PS51379. 4FE4S_FER_2. 2 hits.
PS00551. MOLYBDOPTERIN_PROK_1. 1 hit.
PS00490. MOLYBDOPTERIN_PROK_2. False negative.
PS00932. MOLYBDOPTERIN_PROK_3. 1 hit.
[Graphical view]
ProDomQ7A057.
[Graphical view] [Entries sharing at least one domain]
BLOCKSSearch...

Other Resources

ProtoNetSearch...

Hide | Top

Entry information

Entry nameFDHL_STAAW
AccessionPrimary (citable) accession number: Q7A057
Entry history
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: July 5, 2004
Last modified: September 2, 2008
This is version 35 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

Hide | Top

Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents