Skip Header

 
Contribute Send feedback

Reviewed, UniProtKB/Swiss-Prot Q7L311 (ARMX2_HUMAN)

Last modified July 22, 2008. Version 37. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Web resources · Cross-references · Entry information · Relevant documents

Hide | Top

Names and origin

Protein namesRecommended name:
    Armadillo repeat-containing X-linked protein 2
      Short name(s)=Protein ALEX2
Alternative name(s):
    ARM protein lost in epithelial cancers on chromosome X 2
Gene names
Name: ARMCX2
Synonyms: ALEX2, KIAA0512
OrganismHomo sapiens (Human)
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Hide | Top

Protein attributes

Sequence length632 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at transcript level.

Hide | Top

General annotation (Comments)

Subcellular location

Membrane; Single-pass membrane proteinPotential.

Tissue specificity

Expressed at high levels ovary, heart, testis, prostate, brain, spleen and colon. Expressed at very low levels in liver and thymus. Not expressed in peripheral blood leukocytes. Not expressed in pancreas and ovarian carcinomas.

Sequence similarities

Contains 3 ARM repeats.

Hide | Top

Ontologies

Keywords

   Cellular componentMembrane
   DomainRepeat
Transmembrane

Gene Ontology (GO)

None. [Check GOA]

Hide | Top

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical view

Molecule processing

Chain1 – 632632Armadillo repeat-containing X-linked protein 2

Regions

Transmembrane7 – 2519 Potential
Repeat376 – 41641ARM 1
Repeat418 – 45740ARM 2
Repeat498 – 53740ARM 3
Compositional bias77 – 277201Ala-rich

Hide | Top

Sequences

Sequence LengthMass (Da)Tools
Q7L311-1 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: 7627CBFFE61C329B

FASTA63265,683
        10         20         30         40         50         60 
MSRVRDAGCV AAGIVIGAGA WYCVYKYTRG RDQTKKRMAK PKNRAVAGTG ARARAGLRAG 

        70         80         90        100        110        120 
FTIDLGSGFS PPTPVRAEAE DRAQDEASAL DTVGAEAVAP AASSAEAQSG AGSQAQEADG 

       130        140        150        160        170        180 
AGVGPKAESV VGAAMASAIA PPPGVTEALG AAEAPAMAGA PKVAEAPREA ETSRAAVPPG 

       190        200        210        220        230        240 
TVVPTEAAAP TEVTEGPGVA APTKVAEAPG VASPTEAAEA PVPATPTGAA APTGAAESPG 

       250        260        270        280        290        300 
TSGSPRTAVV PGTSAAKKAT PGAHTGAIPK ATSATGAVPK GGGKGVTRSR NGGKGKGKKS 

       310        320        330        340        350        360 
KVEVDELGMG FRPGDGAAAA AAASANGGQA FLAEVPDSEE GESGWTDTES DSDSEPETQR 

       370        380        390        400        410        420 
RGRGRRPVAM QKRPFPYEID EILGVRDLRK VLALLQKSDD PFIQQVALLT LSNNANYSCN 

       430        440        450        460        470        480 
QETIRKLGGL PIIANMINKT DPHIKEKALM AMNNLSENYE NQGRLQVYMN KVMDDIMASN 

       490        500        510        520        530        540 
LNSAVQVVGL KFLTNMTITN DYQHLLVNSI ANFFRLLSQG GGKIKVEILK ILSNFAENPD 

       550        560        570        580        590        600 
MLKKLLSTQV PASFSSLYNS YVESEILINA LTLFEIIYDN LRAEVFNYRE FNKGSLFYLC 

       610        620        630 
TTSGVCVKKI RALANHHDLL VKVKVIKLVN KF

« Hide

Hide | Top

References

« Hide 'large scale' references
[1]"Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."
Nagase T., Ishikawa K., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
DNA Res. 5:31-39(1998) [PubMed: 9628581] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
[2]"The DNA sequence of the human X chromosome."
Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C. expand/collapse author list , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
Nature 434:325-337(2005) [PubMed: 15772651] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Placenta and Skin.
[4]"ALEX1, a novel human armadillo repeat protein that is expressed differentially in normal tissues and carcinomas."
Kurochkin I.V., Yonemitsu N., Funahashi S., Nomura H.
Biochem. Biophys. Res. Commun. 280:340-347(2001) [PubMed: 11162520] [Abstract]
Cited for: TISSUE SPECIFICITY.

Hide | Top

Cross-references

Sequence databases

AB011084 mRNA. Translation: BAA25438.2. Different initiation.
Z83131 Genomic DNA. Translation: CAI42019.1.
Z83131 Genomic DNA. Translation: CAI42022.1.
BC012541 mRNA. Translation: AAH12541.1.
BC015926 mRNA. Translation: AAH15926.1.
PIRT00084.
RefSeqNP_055597.1.
NP_808818.1.
UniGeneHs.48924

3D structure databases

ModBaseSearch...

Genome annotation databases

EnsemblENSG00000184867. Homo sapiens. [Contig view]
GeneID9823.
KEGGhsa:9823.

Organism-specific databases

H-InvDBHIX0016933.
HGNCHGNC:16869. ARMCX2.
MIM300363. gene.
PharmGKBPA134985862.
HUGESearch...
GenAtlasSearch...
GeneCardsSearch...
GeneLynxSearch...

Phylogenomic databases

HOGENOMQ7L311.
HOVERGENQ7L311.

Gene expression databases

ArrayExpressQ7L311.
CleanExHS_ARMCX2.
GermOnlineENSG00000184867. Homo sapiens.

Family and domain databases

InterProIPR011989. ARM-like.
IPR000225. Armadillo.
IPR006911. DUF634.
[Graphical view]
Gene3DG3DSA:1.25.10.10. ARM-like. 1 hit.
PfamPF04826. DUF634. 1 hit.
[Graphical view]
PROSITEPS50176. ARM_REPEAT. False negative.
[Graphical view]
ProDomQ7L311.
[Graphical view] [Entries sharing at least one domain]
BLOCKSSearch...

Other Resources

SOURCESearch...
ProtoNetSearch...

Hide | Top

Entry information

Entry nameARMX2_HUMAN
AccessionPrimary (citable) accession number: Q7L311
Secondary accession number(s): O60267, Q5H9D9
Entry history
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: July 5, 2004
Last modified: July 22, 2008
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

Hide | Top

Relevant documents

Human chromosome X

Human chromosome X: entries, gene names and cross-references to MIM

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

UniProtKB secondary accession numbers

Index of UniProtKB secondary accession numbers

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Web resources · Cross-references · Entry information · Relevant documents