Reviewed, UniProtKB/Swiss-Prot Q7Z5J8 (ANKAR_HUMAN)

Names and origin

Protein names

Recommended name:
    Ankyrin and armadillo repeat-containing protein

Gene names

Name:

ANKAR

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	1434 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Subcellular location	Membrane; Single-pass membrane proteinPotential.
Tissue specificity	Ubiquitously expressed with highest level in pancreas and lowest in skeletal muscle.
Sequence similarities	Contains 5 ANK repeats. Contains 6 ARM repeats.

Ontologies

Keywords
Cellular component	Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	ANK repeat Repeat Transmembrane
Gene Ontology (GO)
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q7Z5J8-1)

Also known as: FLJ25415-2P;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q7Z5J8-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1066-1080: VAHTSNPVSQQFVVD → YLLKSRLCINTFCLQ
     1081-1434: Missing.

Notes: No experimental confirmation available.

Isoform 3 (identifier: Q7Z5J8-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-236: Missing.
     878-878: S → SGLFNLFLNSFE
     1012-1026: GEAVIALSKDSRMHQ → YLLKSRLCINTFCLQ
     1027-1434: Missing.

Notes: No experimental confirmation available.

Isoform 4 (identifier: Q7Z5J8-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1-332: Missing.
     706-716: VEMLQCESYKR → KCYSVKAINEG
     717-1434: Missing.

Notes: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1434	1434	Ankyrin and armadillo repeat-containing protein		PRO_0000286806
Regions
	Transmembrane	309 – 329	21	Potential
	Repeat	532 – 561	30	ANK 1
	Repeat	569 – 598	30	ANK 2
	Repeat	602 – 631	30	ANK 3
	Repeat	638 – 667	30	ANK 4
	Repeat	671 – 701	31	ANK 5
	Repeat	732 – 771	40	ARM 1
	Repeat	773 – 812	40	ARM 2
	Repeat	814 – 852	39	ARM 3
	Repeat	855 – 894	40	ARM 4
	Repeat	897 – 936	40	ARM 5
	Repeat	1072 – 1112	41	ARM 6
Natural variations
	Alternative sequence	1 – 332	332	Missing in isoform 4.		VSP_025166
	Alternative sequence	1 – 236	236	Missing in isoform 3.		VSP_025167
	Alternative sequence	706 – 716	11	VEMLQCESYKR → KCYSVKAINEG in isoform 4.		VSP_025168
	Alternative sequence	717 – 1434	718	Missing in isoform 4.		VSP_025169
	Alternative sequence	878	1	S → SGLFNLFLNSFE in isoform 3.		VSP_025170
	Alternative sequence	1012 – 1026	15	GEAVI…SRMHQ → YLLKSRLCINTFCLQ in isoform 3.		VSP_025171
	Alternative sequence	1027 – 1434	408	Missing in isoform 3.		VSP_025172
	Alternative sequence	1066 – 1080	15	VAHTS…QFVVD → YLLKSRLCINTFCLQ in isoform 2.		VSP_025173
	Alternative sequence	1081 – 1434	354	Missing in isoform 2.		VSP_025174
	Natural variant	675	1	I → V: dbSNP rs16831887.		VAR_032164
	Natural variant	1077	1	F → L: dbSNP rs1225090.		VAR_032165
Experimental info
	Sequence conflict	8	1	G → R in BAC86425. Ref.1
	Sequence conflict	207	1	K → R in BAC86425. Ref.1
	Sequence conflict	436	1	S → G in AAH47413. Ref.3
	Sequence conflict	623	1	C → Y in AAH47413. Ref.3
	Sequence conflict	679	1	S → L in AAH47413. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (FLJ25415-2P) [UniParc]. Last modified May 15, 2007. Version 2. Checksum: 3BCC0B40B8AA940B	FASTA	1,434	162,060
	10 20 30 40 50 60 MLRLPKKGLP RFEQVQDEDT YLENLAIQRN ASAFFEKYDR SEIQELLTTA LVSWLSAKED 70 80 90 100 110 120 VRSQVDLPCG IMSQMNNVGF STAILLTPVD PTALLDYREV HQMIRELAIG IYCLNQIPSI 130 140 150 160 170 180 SLEANYDQSS SCQLPPAYYD TRIGQILINI DYMLKALWHG IYMPKEKRAR FSELWRAIMD 190 200 210 220 230 240 IDPDGKPQTN KDIFSEFSSA GLTDITKDPD FNEIYDEDVN EDPTYDPNSP EETAVFMKYA 250 260 270 280 290 300 ENIMLKLTFS TTQIQQYENV FIFETGYWLT NAIKYNQDYL DICTYQRLQQ RLYLQKKIIQ 310 320 330 340 350 360 KHFEKKKDIR RGIGYLKLIC FLIPFLLSLK KKMKVPYLSS LLQPFSDDKV KTERELPPFI 370 380 390 400 410 420 YGRDFKCQNF HYKENQYFHV HGGIEFDIST PSIENALEDF QKNLEKIRDC AANTFIEDSG 430 440 450 460 470 480 YKEYYSIPVM EFHGKSYYVI YFELETFYQQ LYKTQWWGAI NEIVNNLRLK RLPLTDAQLH 490 500 510 520 530 540 EQFKKKLGFK RAMKCKSIPF GMKSAVERGL SAVFHTFSRK TSSSTINVSD EAGYTIFHHA 550 560 570 580 590 600 ALHNRVSIIC QLCNANFKVN QRRFVTFSQG PTPLHLAAQA CSLETTVCLL CSKADYTLSE 610 620 630 640 650 660 KRGWMPIHFA AFYDNVCIII ALCRKDPSLL EAEATAENQC TPLLLAATSG ALDTIQYLFS 670 680 690 700 710 720 IGANWRKTDI KGNNIIHLSV LTFHTEVLKY IIKLNIPELP VWKTLVEMLQ CESYKRRMMA 730 740 750 760 770 780 VMSLEVICLA NDQYWRCILD AGTIPALINL LKSSKIKLQC KTVGLLSNIS THKSAVHALV 790 800 810 820 830 840 EAGGIPSLIN LLVCDEPEVH SRCAVILYDI AQCENKDVIA KYNGIPSLIN LLNLNIENVL 850 860 870 880 890 900 VNVMNCIRVL CIGNENNQRA VREHKGLPYL IRFLSSDSDV LKAVSSAAIA EVGRDNKEIQ 910 920 930 940 950 960 DAIAMEGAIP PLVALFKGKQ ISVQMKGAMA VESLASHNAL IQKAFLEKSL TKYLLKLLKA 970 980 990 1000 1010 1020 FQIDVKEQGA VALWALAGQT LKQQKYMAEQ IGYSFIINML LSPSAKMQYV GGEAVIALSK 1030 1040 1050 1060 1070 1080 DSRMHQNQIC EGNGIAPLVR LLRISTIAEG TLLSVIRAVG SICIGVAHTS NPVSQQFVVD 1090 1100 1110 1120 1130 1140 ENAFPVLIQL LRNHPSPNIK VEVAFSLACI VLGNDVLQKD LHENEGFEYA DVLYLLHSTE 1150 1160 1170 1180 1190 1200 KDICLRAGYA LTLFAFNNRF QQYLILESGI MTISIFERFL ESTVETEKAM AAFQIVVLAK 1210 1220 1230 1240 1250 1260 VIRDMDHITL SARGVTILVD SLYSVQTSTI VLTGNLIASL AHSRAGIPEA FTTLGTIQRL 1270 1280 1290 1300 1310 1320 CYHLYSGIEE VRAACSSALG YLTYNANAFR ILLKECRNKP NQFIRIKNNI SRDASINPAF 1330 1340 1350 1360 1370 1380 LKEFQMQQTL VGLPSLSLEK NGGPSIIPIF KRGKEHRRKL KPKIQPKDSL TLLPPVTNFM 1390 1400 1410 1420 1430 GLFKATKKTK DSHNIFSFSS TITSDITNVS RPRIVCLNQL GKHVQKANPE PAEG
	Isoform 2 [UniParc]. Checksum: C29679373ECAAA45		1,080	122,726
	10 20 30 40 50 60 MLRLPKKGLP RFEQVQDEDT YLENLAIQRN ASAFFEKYDR SEIQELLTTA LVSWLSAKED 70 80 90 100 110 120 VRSQVDLPCG IMSQMNNVGF STAILLTPVD PTALLDYREV HQMIRELAIG IYCLNQIPSI 130 140 150 160 170 180 SLEANYDQSS SCQLPPAYYD TRIGQILINI DYMLKALWHG IYMPKEKRAR FSELWRAIMD 190 200 210 220 230 240 IDPDGKPQTN KDIFSEFSSA GLTDITKDPD FNEIYDEDVN EDPTYDPNSP EETAVFMKYA 250 260 270 280 290 300 ENIMLKLTFS TTQIQQYENV FIFETGYWLT NAIKYNQDYL DICTYQRLQQ RLYLQKKIIQ 310 320 330 340 350 360 KHFEKKKDIR RGIGYLKLIC FLIPFLLSLK KKMKVPYLSS LLQPFSDDKV KTERELPPFI 370 380 390 400 410 420 YGRDFKCQNF HYKENQYFHV HGGIEFDIST PSIENALEDF QKNLEKIRDC AANTFIEDSG 430 440 450 460 470 480 YKEYYSIPVM EFHGKSYYVI YFELETFYQQ LYKTQWWGAI NEIVNNLRLK RLPLTDAQLH 490 500 510 520 530 540 EQFKKKLGFK RAMKCKSIPF GMKSAVERGL SAVFHTFSRK TSSSTINVSD EAGYTIFHHA 550 560 570 580 590 600 ALHNRVSIIC QLCNANFKVN QRRFVTFSQG PTPLHLAAQA CSLETTVCLL CSKADYTLSE 610 620 630 640 650 660 KRGWMPIHFA AFYDNVCIII ALCRKDPSLL EAEATAENQC TPLLLAATSG ALDTIQYLFS 670 680 690 700 710 720 IGANWRKTDI KGNNIIHLSV LTFHTEVLKY IIKLNIPELP VWKTLVEMLQ CESYKRRMMA 730 740 750 760 770 780 VMSLEVICLA NDQYWRCILD AGTIPALINL LKSSKIKLQC KTVGLLSNIS THKSAVHALV 790 800 810 820 830 840 EAGGIPSLIN LLVCDEPEVH SRCAVILYDI AQCENKDVIA KYNGIPSLIN LLNLNIENVL 850 860 870 880 890 900 VNVMNCIRVL CIGNENNQRA VREHKGLPYL IRFLSSDSDV LKAVSSAAIA EVGRDNKEIQ 910 920 930 940 950 960 DAIAMEGAIP PLVALFKGKQ ISVQMKGAMA VESLASHNAL IQKAFLEKSL TKYLLKLLKA 970 980 990 1000 1010 1020 FQIDVKEQGA VALWALAGQT LKQQKYMAEQ IGYSFIINML LSPSAKMQYV GGEAVIALSK 1030 1040 1050 1060 1070 1080 DSRMHQNQIC EGNGIAPLVR LLRISTIAEG TLLSVIRAVG SICIGYLLKS RLCINTFCLQ
	Isoform 3 [UniParc]. Checksum: 75F1D126E1CB0EFC		801	91,350
	10 20 30 40 50 60 MKYAENIMLK LTFSTTQIQQ YENVFIFETG YWLTNAIKYN QDYLDICTYQ RLQQRLYLQK 70 80 90 100 110 120 KIIQKHFEKK KDIRRGIGYL KLICFLIPFL LSLKKKMKVP YLSSLLQPFS DDKVKTEREL 130 140 150 160 170 180 PPFIYGRDFK CQNFHYKENQ YFHVHGGIEF DISTPSIENA LEDFQKNLEK IRDCAANTFI 190 200 210 220 230 240 EDSGYKEYYS IPVMEFHGKS YYVIYFELET FYQQLYKTQW WGAINEIVNN LRLKRLPLTD 250 260 270 280 290 300 AQLHEQFKKK LGFKRAMKCK SIPFGMKSAV ERGLSAVFHT FSRKTSSSTI NVSDEAGYTI 310 320 330 340 350 360 FHHAALHNRV SIICQLCNAN FKVNQRRFVT FSQGPTPLHL AAQACSLETT VCLLCSKADY 370 380 390 400 410 420 TLSEKRGWMP IHFAAFYDNV CIIIALCRKD PSLLEAEATA ENQCTPLLLA ATSGALDTIQ 430 440 450 460 470 480 YLFSIGANWR KTDIKGNNII HLSVLTFHTE VLKYIIKLNI PELPVWKTLV EMLQCESYKR 490 500 510 520 530 540 RMMAVMSLEV ICLANDQYWR CILDAGTIPA LINLLKSSKI KLQCKTVGLL SNISTHKSAV 550 560 570 580 590 600 HALVEAGGIP SLINLLVCDE PEVHSRCAVI LYDIAQCENK DVIAKYNGIP SLINLLNLNI 610 620 630 640 650 660 ENVLVNVMNC IRVLCIGNEN NQRAVREHKG LPYLIRFLSS DSGLFNLFLN SFEDVLKAVS 670 680 690 700 710 720 SAAIAEVGRD NKEIQDAIAM EGAIPPLVAL FKGKQISVQM KGAMAVESLA SHNALIQKAF 730 740 750 760 770 780 LEKSLTKYLL KLLKAFQIDV KEQGAVALWA LAGQTLKQQK YMAEQIGYSF IINMLLSPSA 790 800 KMQYVGYLLK SRLCINTFCL Q
	Isoform 4 [UniParc]. Checksum: 3E16C2EDAAEEA5F4		384	44,059
	10 20 30 40 50 60 MKVPYLSSLL QPFSDDKVKT ERELPPFIYG RDFKCQNFHY KENQYFHVHG GIEFDISTPS 70 80 90 100 110 120 IENALEDFQK NLEKIRDCAA NTFIEDSGYK EYYSIPVMEF HGKSYYVIYF ELETFYQQLY 130 140 150 160 170 180 KTQWWGAINE IVNNLRLKRL PLTDAQLHEQ FKKKLGFKRA MKCKSIPFGM KSAVERGLSA 190 200 210 220 230 240 VFHTFSRKTS SSTINVSDEA GYTIFHHAAL HNRVSIICQL CNANFKVNQR RFVTFSQGPT 250 260 270 280 290 300 PLHLAAQACS LETTVCLLCS KADYTLSEKR GWMPIHFAAF YDNVCIIIAL CRKDPSLLEA 310 320 330 340 350 360 EATAENQCTP LLLAATSGAL DTIQYLFSIG ANWRKTDIKG NNIIHLSVLT FHTEVLKYII 370 380 KLNIPELPVW KTLKCYSVKA INEG

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Testis.
[2]	"Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K. Nature 434:724-731(2005) [PubMed: 15815621] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT LEU-1077.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3 AND 4). Tissue: Testis.
[4]	"Characterization of a novel human gene containing ANK repeats and ARM domains." Occhi G., Olivieri M., Rampazzo A., Danieli G.A. Biochem. Biophys. Res. Commun. 318:38-45(2004) [PubMed: 15110750] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 72-1434 (ISOFORM 1), ALTERNATIVE SPLICING, TISSUE SPECIFICITY. Tissue: Heart.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AC013468 Genomic DNA. No translation available. AC012488 Genomic DNA. No translation available. AK126073 mRNA. Translation: BAC86425.1. BC044907 mRNA. Translation: AAH44907.1. BC047413 mRNA. Translation: AAH47413.1. AJ549812 mRNA. Translation: CAD71147.1.
RefSeq	NP_653309.2.
UniGene	Hs.655700
3D structure databases
ModBase	Search...
PTM databases
PhosphoSite	Q7Z5J8.
Genome annotation databases
Ensembl	ENSG00000151687. Homo sapiens. [Contig view]
GeneID	150709.
KEGG	hsa:150709.
Organism-specific databases
HGNC	HGNC:26350. ANKAR.
MIM	609803. gene.
GenAtlas	Search...
GeneCards	Search...
Phylogenomic databases
HOGENOM	Q7Z5J8.
HOVERGEN	Q7Z5J8.
Gene expression databases
ArrayExpress	Q7Z5J8.
CleanEx	HS_ANKAR.
Family and domain databases
InterPro	IPR002110. ANK. IPR011989. ARM-like. IPR000225. Armadillo. [Graphical view]
Gene3D	G3DSA:1.25.40.20. ANK. 1 hit. G3DSA:1.25.10.10. ARM-like. 2 hits.
Pfam	PF00023. Ank. 5 hits. PF00514. Arm. 5 hits. [Graphical view]
PRINTS	PR01415. ANKYRIN.
SMART	SM00248. ANK. 5 hits. SM00185. ARM. 7 hits. [Graphical view]
PROSITE	PS50297. ANK_REP_REGION. 1 hit. PS50088. ANK_REPEAT. 2 hits. PS50176. ARM_REPEAT. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	86508.
SOURCE	Search...