Reviewed, UniProtKB/Swiss-Prot Q821R2 (SYA_CHLCV)

Names and origin

Protein names

Recommended name:
    Alanyl-tRNA synthetase
    EC=6.1.1.7
Alternative name(s):
    Alanine--tRNA ligase
      Short name=AlaRS

Gene names

Name:	alaS
Ordered Locus Names:	CCA_00876

Organism

Chlamydophila caviae [Complete proteome] [HAMAP]

Taxonomic identifier

83557 [NCBI]

Taxonomic lineage

Bacteria › Chlamydiae › Chlamydiales › Chlamydiaceae › Chlamydophila

Protein attributes

Sequence length	875 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	ATP + L-alanine + tRNA(Ala) = AMP + diphosphate + L-alanyl-tRNA(Ala).
Subcellular location	Cytoplasm.
Sequence similarities	Belongs to the class-II aminoacyl-tRNA synthetase family.

Ontologies

Keywords
Biological process	Protein biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Aminoacyl-tRNA synthetase Ligase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	alanyl-tRNA aminoacylation Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: HAMAP
Molecular function	ATP binding Inferred from electronic annotation. Source: HAMAP alanine-tRNA ligase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view
Molecule processing
	Chain	1 – 875	875	Alanyl-tRNA synthetase

Sequences

	Sequence		Length	Mass (Da)
	Q821R2-1 [UniParc]. Last modified June 1, 2003. Version 1. Checksum: D8FBF19DE4339FEE	FASTA	875	98,196
	10 20 30 40 50 60 MLSNTLRSNF LKFYANRHHT IVPSSPVFPH NDPSILFTNA GMNQFKDIFL NKETVSYSRA 70 80 90 100 110 120 TTSQKCIRAG GKHNDLDNVG HTSRHLTFFE MLGNFSFGDY FKEQAIAFAW EVSLSVFNLD 130 140 150 160 170 180 PDRIYATVHE KDDEAFALWE KHLPSERIFR LTDKDNFWSM AETGPCGYCS ELLFDRGEKF 190 200 210 220 230 240 GTAASPLEDT EGERFLEYWN LVFMEFNRTA EGSLLALPNK HVDTGAGLER LVSILSGTNT 250 260 270 280 290 300 VFEADVLRLL ISKTEQLSGK TYHADEALGA AFRVIADHTR SLSFAIADGL LPGNTERGYV 310 320 330 340 350 360 LRKILRRAVN YGKRLGFTQP FLADIVPSLV DTMGEAYPEL RLSLSQIQEV MTMEEENYFK 370 380 390 400 410 420 SLHRGGNLLQ QVLKSSSSSS IISGEDAFKL KDTYGLPLDE IALLAKDYDF TVDMETFYQL 430 440 450 460 470 480 EEEAKERSRK NIAKSHSSTD TVYDSLSLGE NSEFVGYNDL SCDTFIEALV SNGKQVSSLK 490 500 510 520 530 540 EKEKGALILK VTPFYAEKGG QIGDSGEIFC SDGTFIVSHT TSPKAGIVIH HGEVSQGQLS 550 560 570 580 590 600 QDQAVTAQVN CIRRKKIGNN HTGCHLLHKA LEVTLGDHIR QAGSYVDDTK IRLDFTHPKA 610 620 630 640 650 660 IAPEDLASIE LLVNEKIREN HRVETREAMY SDVMNSKEIK QFFGDKYSDV VRVVSAGFSH 670 680 690 700 710 720 ELCGGTHAEF TGDLGYFRIL KEHAVATGIR RIEAVTGREA EALAHQDNEN LNEIALVLQS 730 740 750 760 770 780 PRDQILNKLQ NVLEERKEQA KQISELENKL IHSLLDKLID GCQQVDDVSY LIHHLPESES 790 800 810 820 830 840 HRLQQYANCL HQKIPLRLIS LWTTQKNGKY IIFSRISDDL VKQGLQAKDL LKIVLTPCGG 850 860 870 RWGGKDIFAQ GSADNLPQAD ALNNTLWQWI STQLI

References

[1]

"Genome sequence of Chlamydophila caviae (Chlamydia psittaci GPIC): examining the role of niche-specific genes in the evolution of the Chlamydiaceae." Read T.D., Myers G.S.A., Brunham R.C., Nelson W.C., Paulsen I.T., Heidelberg J.F., Holtzapple E.K., Khouri H.M., Federova N.B., Carty H.A., Umayam L.A., Haft D.H., Peterson J.D., Beanan M.J., White O., Salzberg S.L., Hsia R.-C., McClarty G. , Rank R.G., Bavoil P.M., Fraser C.M. Nucleic Acids Res. 31:2134-2147(2003) [PubMed: 12682364] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: GPIC.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE015925 Genomic DNA. Translation: AAP05617.1.
RefSeq	NP_829739.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	1218561.
GenomeReviews	Gene locus CCA_00876 in contig AE015925_GR.
KEGG	cca:CCA00876.
TIGR	CCA_00876.
Phylogenomic databases
HOGENOM	Q821R2.
Enzyme and pathway databases
BioCyc	CCAV227941:CCA_00876-MON.
Family and domain databases
HAMAP	MF_00036. [Tree]
InterPro	IPR002318. Ala-tRNA-synth_IIc. IPR003156. Pesterase_DHHA1. IPR012947. tRNA_SAD. [Graphical view]
Pfam	PF02272. DHHA1. 1 hit. PF01411. tRNA-synt_2c. 1 hit. PF07973. tRNA_SAD. 1 hit. [Graphical view]
PRINTS	PR00980. TRNASYNTHALA.
TIGRFAMs	TIGR00344. alaS. 1 hit.
PROSITE	PS50860. AA_TRNA_LIGASE_II_ALA. 1 hit. [Graphical view]
ProDom	Q821R2. [Graphical view] [Entries sharing at least one domain]
BLOCKS	Search...
Other Resources
ProtoNet	Search...

Entry information

Entry name

SYA_CHLCV

Accession

Primary (citable) accession number: Q821R2

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 25, 2003
Last sequence update:	June 1, 2003
Last modified:	July 22, 2008
This is version 29 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)