Reviewed, UniProtKB/Swiss-Prot Q83EP0 (DCUP_COXBU)

Names and origin

Protein names

Recommended name:
    Uroporphyrinogen decarboxylase
      Short name=URO-D
      Short name=UPD
    EC=4.1.1.37

Gene names

Name:	hemE
Ordered Locus Names:	CBU_0275

Organism

Coxiella burnetii [Complete proteome] [HAMAP]

Taxonomic identifier

777 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Legionellales › Coxiellaceae › Coxiella

Protein attributes

Sequence length	361 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen III to yield coproporphyrinogen III By similarity.
Catalytic activity	Uroporphyrinogen III = coproporphyrinogen + 4 CO(2).
Pathway	Porphyrin metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen III from 5-aminolevulinate: step 4/4.
Subunit structure	Homodimer By similarity.
Subcellular location	CytoplasmProbable.
Sequence similarities	Belongs to the uroporphyrinogen decarboxylase family.

Ontologies

Keywords
Biological process	Porphyrin biosynthesis
Cellular component	Cytoplasm
Molecular function	Decarboxylase Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	porphyrin biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: HAMAP
Molecular function	uroporphyrinogen decarboxylase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view
Molecule processing
	Chain	1 – 361	361	Uroporphyrinogen decarboxylase
Regions
	Region	27 – 31	5	Substrate binding By similarity
Sites
	Binding site	46	1	Substrate By similarity
	Binding site	77	1	Substrate By similarity
	Binding site	154	1	Substrate By similarity
	Binding site	209	1	Substrate By similarity
	Binding site	327	1	Substrate By similarity
	Site	77	1	Transition state stabilizer By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q83EP0-1 [UniParc]. Last modified June 1, 2003. Version 1. Checksum: 24588B34D4399357	FASTA	361	40,203
	10 20 30 40 50 60 MLRLKNDRFI RALLRQPVDR TPVWIMRQAG RYLPEYRQLR EKVPNFMAFC KTPELACEAT 70 80 90 100 110 120 LQPLRRFPLD AAIIFSDILT IPDAMGVDLH IAPTVGPVIR NPVRSAQDVN RLQMPAVEEA 130 140 150 160 170 180 LSYLFDAIRL TVKALDHRVP LIGFAGSPWT LACYMTEGQS SKTFLTARAM LYQQPDVFHT 190 200 210 220 230 240 LLQKLTTLTI AYLNAQIKAG ADVVMLFDTW GGLLTPSLYR QFSLDYLSQI AAEVVRQKNG 250 260 270 280 290 300 RKIPLIFFTK NGGQWLESIA NSGCDAVGLD WTTDIGQARR RVGDRVALQG NLDPAILLSN 310 320 330 340 350 360 PESISTAAVD ILKSYGQGSG HVFNLGHGID PSTPIENVAA LVEAVQNFSI KNEKPISSYY R

References

[1]

"Complete genome sequence of the Q-fever pathogen, Coxiella burnetii." Seshadri R., Paulsen I.T., Eisen J.A., Read T.D., Nelson K.E., Nelson W.C., Ward N.L., Tettelin H., Davidsen T.M., Beanan M.J., DeBoy R.T., Daugherty S.C., Brinkac L.M., Madupu R., Dodson R.J., Khouri H.M., Lee K.H., Carty H.A. , Scanlan D., Heinzen R.A., Thompson H.A., Samuel J.E., Fraser C.M., Heidelberg J.F. Proc. Natl. Acad. Sci. U.S.A. 100:5455-5460(2003) [PubMed: 12704232] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Nine Mile phase I / RSA 493.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE016828 Genomic DNA. Translation: AAO89833.1.
RefSeq	NP_819319.1.
3D structure databases
HSSP	HSSP built from PDB template 1JPH based on UniProtKB P06132.
ModBase	Search...
Genome annotation databases
GeneID	1208156.
GenomeReviews	Gene locus CBU_0275 in contig AE016828_GR.
KEGG	cbu:CBU_0275.
NMPDR	fig|227377.1.peg.263.
TIGR	CBU_0275.
Phylogenomic databases
HOGENOM	Q83EP0.
Enzyme and pathway databases
BioCyc	CBUR227377:CBU_0275-MON.
Family and domain databases
HAMAP	MF_00218. [Tree]
InterPro	IPR006361. HemE. IPR000257. uPrphyn_de-COase. [Graphical view]
PANTHER	PTHR21091:SF2. HemE. 1 hit.
Pfam	PF01208. URO-D. 1 hit. [Graphical view]
ProDom	PD003225. Uro_decarbxyls. 2 hits. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR01464. hemE. 1 hit.
PROSITE	PS00906. UROD_1. 1 hit. PS00907. UROD_2. 1 hit. [Graphical view]
BLOCKS	Search...
Other Resources
ProtoNet	Search...

Entry information

Entry name

DCUP_COXBU

Accession

Primary (citable) accession number: Q83EP0

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 7, 2003
Last sequence update:	June 1, 2003
Last modified:	July 22, 2008
This is version 40 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)