Reviewed, UniProtKB/Swiss-Prot Q83ES9 (RS12_COXBU)

Names and origin

Protein names

Recommended name:
    30S ribosomal protein S12

Gene names

Name:	rpsL
Ordered Locus Names:	CBU_0233

Organism

Coxiella burnetii [Complete proteome] [HAMAP]

Taxonomic identifier

777 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Legionellales › Coxiellaceae › Coxiella

Protein attributes

Sequence length	124 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	With S4 and S5 plays an important role in translational accuracy By similarity. Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit By similarity.
Subunit structure	Part of the 30S ribosomal subunit. Contacts proteins S8 and S17. May interact with IF1 in the 30S initiation complex By similarity.
Sequence similarities	Belongs to the ribosomal protein S12P family.

Ontologies

Keywords
Ligand	RNA-binding rRNA-binding tRNA-binding
Molecular function	Ribonucleoprotein Ribosomal protein
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	translation Inferred from electronic annotation. Source: HAMAP
Molecular function	rRNA binding Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view
Molecule processing
	Chain	1 – 124	124	30S ribosomal protein S12
Amino acid modifications
	Modified residue	89	1	3-methylthioaspartic acid By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q83ES9-1 [UniParc]. Last modified June 1, 2003. Version 1. Checksum: CB4EB41201253A9D	FASTA	124	13,753
	10 20 30 40 50 60 MARINQLVRK PRRARAKKSD VPALEGCPQR RGVCTRVYTT TPKKPNSALR KVARVRITNG 70 80 90 100 110 120 AEVTAYIGGE GHNLQEHSVV LIRGGRVKDL PGVRYHIVRG SLDTAGVSGR RRGRSKYGEK KPKE

References

[1]

"Complete genome sequence of the Q-fever pathogen, Coxiella burnetii." Seshadri R., Paulsen I.T., Eisen J.A., Read T.D., Nelson K.E., Nelson W.C., Ward N.L., Tettelin H., Davidsen T.M., Beanan M.J., DeBoy R.T., Daugherty S.C., Brinkac L.M., Madupu R., Dodson R.J., Khouri H.M., Lee K.H., Carty H.A. , Scanlan D., Heinzen R.A., Thompson H.A., Samuel J.E., Fraser C.M., Heidelberg J.F. Proc. Natl. Acad. Sci. U.S.A. 100:5455-5460(2003) [PubMed: 12704232] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Nine Mile phase I / RSA 493.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE016828 Genomic DNA. Translation: AAO89791.1.
RefSeq	NP_819277.1.
3D structure databases
SMR	Q83ES9. Positions 2-123.
ModBase	Search...
Genome annotation databases
GeneID	1208114.
GenomeReviews	Gene locus CBU_0233 in contig AE016828_GR.
KEGG	cbu:CBU_0233.
NMPDR	fig|227377.1.peg.221.
TIGR	CBU_0233.
Phylogenomic databases
HOGENOM	Q83ES9.
Enzyme and pathway databases
BioCyc	CBUR227377:CBU_0233-MON.
Family and domain databases
HAMAP	MF_00403. [Tree]
InterPro	IPR012340. NA-bd_OB-fold. IPR006032. Ribosomal_S12/S23. IPR005679. Ribosomal_S12_bac-type. [Graphical view]
Gene3D	G3DSA:2.40.50.140. OB_NA_bd_sub. 1 hit.
PANTHER	PTHR11652:SF1. Ribosom_S12_bac. 1 hit. PTHR11652. Ribosomal_S12_23. 1 hit.
Pfam	PF00164. Ribosomal_S12. 1 hit. [Graphical view]
PIRSF	PIRSF002133. Ribosomal_S12/S23. 1 hit.
PRINTS	PR01034. RIBOSOMALS12.
TIGRFAMs	TIGR00981. rpsL_bact. 1 hit.
PROSITE	PS00055. RIBOSOMAL_S12. 1 hit. [Graphical view]
ProDom	Q83ES9. [Graphical view] [Entries sharing at least one domain]
BLOCKS	Search...
Other Resources
ProtoNet	Search...

Entry information

Entry name

RS12_COXBU

Accession

Primary (citable) accession number: Q83ES9

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 27, 2004
Last sequence update:	June 1, 2003
Last modified:	July 22, 2008
This is version 38 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)