Reviewed, UniProtKB/Swiss-Prot Q83EX9 (ANMK_COXBU)

Names and origin

Protein names

Recommended name:
    Anhydro-N-acetylmuramic acid kinase
    EC=2.7.1.n1
Alternative name(s):
    AnhMurNAc kinase

Gene names

Name:	anmK
Ordered Locus Names:	CBU_0179

Organism

Coxiella burnetii [Complete proteome] [HAMAP]

Taxonomic identifier

777 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Legionellales › Coxiellaceae › Coxiella

Protein attributes

Sequence length	372 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the specific phosphorylation of 1,6-anhydro-N-acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling By similarity.
Catalytic activity	ATP + 1,6-anhydro-N-acetylmuramic acid + H(2)O = ADP + N-acetylmuramic acid 6-phosphate.
Pathway	Amino-sugar metabolism; anhydro-N-acetylmuramic acid degradation. Cell wall biosynthesis; peptidoglycan recycling.
Sequence similarities	Belongs to the anhydro-N-acetylmuramic acid kinase family.

Ontologies

Keywords
Biological process	Carbohydrate metabolism
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	amino sugar metabolic process Inferred from electronic annotation. Source: HAMAP peptidoglycan turnover Inferred from electronic annotation. Source: HAMAP
Molecular function	ATP binding Inferred from electronic annotation. Source: HAMAP phosphotransferase activity, alcohol group as acceptor Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view
Molecule processing
	Chain	1 – 372	372	Anhydro-N-acetylmuramic acid kinase
Regions
	Nucleotide binding	12 – 19	8	ATP Potential

Sequences

	Sequence		Length	Mass (Da)
	Q83EX9-1 [UniParc]. Last modified June 1, 2003. Version 1. Checksum: F8832DC78B238E5F	FASTA	372	40,679
	10 20 30 40 50 60 MPKERYIGLI SGTSMDALDT ALVQFDPLKI IATHGEPIPT ELKKNLVALS TGTDNSIPSM 70 80 90 100 110 120 GETDVALGRL FGEAVLTLLE KAKVSSDSIQ AIGSHGQTIR HMPNGKHPFT LQIGDPNTIA 130 140 150 160 170 180 ALTGITTVAD FRRRDMALGG QGAPLAPAFH EFLLRDQSEN RLILNIGGIA NLTFLPRDPE 190 200 210 220 230 240 KSTIGFDTGP GNTLLDAWCL MNLNKDYDDQ GQWAASGRVQ EKLVAQLLAE PYFQTPPPKS 250 260 270 280 290 300 TGREYFNLNW LKKNLNGEKF DPVDIQATLV ELTARSVANC CRNFSMDSGS LWLCGGGARN 310 320 330 340 350 360 HHLVNRLKVL CKPLRVTTTE EIGIHPDWLE AVCFAWLAKQ TLEKKPGNLP SVTGAKKSAI 370 LGAIYWGEKF NY

References

[1]

"Complete genome sequence of the Q-fever pathogen, Coxiella burnetii." Seshadri R., Paulsen I.T., Eisen J.A., Read T.D., Nelson K.E., Nelson W.C., Ward N.L., Tettelin H., Davidsen T.M., Beanan M.J., DeBoy R.T., Daugherty S.C., Brinkac L.M., Madupu R., Dodson R.J., Khouri H.M., Lee K.H., Carty H.A. , Scanlan D., Heinzen R.A., Thompson H.A., Samuel J.E., Fraser C.M., Heidelberg J.F. Proc. Natl. Acad. Sci. U.S.A. 100:5455-5460(2003) [PubMed: 12704232] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Nine Mile phase I / RSA 493.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE016828 Genomic DNA. Translation: AAO89739.1.
RefSeq	NP_819225.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	1208051.
GenomeReviews	Gene locus CBU_0179 in contig AE016828_GR.
KEGG	cbu:CBU_0179.
NMPDR	fig|227377.1.peg.169.
TIGR	CBU_0179.
Phylogenomic databases
HOGENOM	Q83EX9.
Enzyme and pathway databases
BioCyc	CBUR227377:CBU_0179-MON.
Family and domain databases
HAMAP	MF_01270. [Tree]
InterPro	IPR005338. UPF0075. [Graphical view]
Pfam	PF03702. UPF0075. 1 hit. [Graphical view]
ProDom	Q83EX9. [Graphical view] [Entries sharing at least one domain]
BLOCKS	Search...
Other Resources
ProtoNet	Search...

Entry information

Entry name

ANMK_COXBU

Accession

Primary (citable) accession number: Q83EX9

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 19, 2006
Last sequence update:	June 1, 2003
Last modified:	July 22, 2008
This is version 29 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)