Reviewed, UniProtKB/Swiss-Prot Q83F06 (SECA_COXBU)

Names and origin

Protein names

Recommended name:
    Protein translocase subunit secA

Gene names

Name:	secA
Ordered Locus Names:	CBU_0147

Organism

Coxiella burnetii [Complete proteome] [HAMAP]

Taxonomic identifier

777 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Legionellales › Coxiellaceae › Coxiella

Protein attributes

Sequence length	913 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Part of the Sec protein translocase complex. Interacts with the secYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-secB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane By similarity.
Cofactor	May bind 1 zinc ion per subunit Potential.
Subunit structure	Monomer and homodimer By similarity. Part of the essential Sec protein translocation apparatus which comprises secA, secYEG and auxiliary proteins secDFyajC and yidC By similarity.
Subcellular location	Cell inner membrane; Peripheral membrane protein; Cytoplasmic sideBy similarity. CytoplasmBy similarity. Note= Distribution is 50-50 By similarity.
Sequence similarities	Belongs to the secA family.

Ontologies

Keywords
Biological process	Protein transport Translocation Transport
Cellular component	Cell inner membrane Cell membrane Cytoplasm Membrane
Ligand	ATP-binding Metal-binding Nucleotide-binding Zinc
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	intracellular protein transport across a membrane Inferred from electronic annotation. Source: HAMAP protein targeting Inferred from electronic annotation. Source: HAMAP
Cellular component	plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view
Molecule processing
	Chain	1 – 913	913	Protein translocase subunit secA
Regions
	Nucleotide binding	102 – 109	8	ATP Potential
Sites
	Metal binding	897	1	Zinc Potential
	Metal binding	899	1	Zinc Potential
	Metal binding	908	1	Zinc Potential
	Metal binding	909	1	Zinc Potential

Sequences

	Sequence		Length	Mass (Da)
	Q83F06-1 [UniParc]. Last modified June 1, 2003. Version 1. Checksum: E98BDF59F6CFC2D7	FASTA	913	103,879
	10 20 30 40 50 60 MLGNIIKKAF GTRNERLLKG YSKIVSRINA LEPEIQALSD ADLRAKTDEF KKRLVDGEGL 70 80 90 100 110 120 DALLPEAFAV VRETSVRTLG LRHFDVQIIG GLALHGGKIA EMRTGEGKTL GATMPAYLNA 130 140 150 160 170 180 LTGKGVHIVT VNDYLAKRDA EWMKPIYEFL GLTVGVNVPG MEPVEKQAAY AADITYGTNN 190 200 210 220 230 240 EFGFDYLRDN MVFDLDQRVQ RPLHYAIIDE VDSILIDEAR TPLIISGQAE ESSDLYVKIN 250 260 270 280 290 300 KFIPQLKLQK MEEGQKEEEV PPENRGDYTL DEKNRQAYLT EQGHRTIEAL MIKQGLMQAG 310 320 330 340 350 360 ESLYDVSNIS LMHYVYAALR AHTLFYRDVH YIVKNNEVII VDEHTGRLMP GRRWSDGLHQ 370 380 390 400 410 420 AVEAKEGATI QLENQTLATI TFQNYFRLYE KLSGMTATAD TEAFELQKIY GLEVVVIPTN 430 440 450 460 470 480 RPMIRRDESD QVYLTADAKF DAIVNEVKKR HEKGQPLLIG TASIEASELV ARFLKKANIK 490 500 510 520 530 540 HEILNAKNHE REAKIIAEAG RPGAVTIATN MAGRGTDIVL GGNLEAEMSE LDNLAEEEIQ 550 560 570 580 590 600 KRKADWQKRH DAVIAAGGLH VLGTERHESR RIDNQLRGRS GRQGDPGSSQ FYLSMEDNLL 610 620 630 640 650 660 RIFAAERMSN MMRRLGVKED DVIEHPWITR AIEKAQRRVE GMNFDIRKQL LEYDDVANDQ 670 680 690 700 710 720 RKVIYQQRFQ LLQTDDISET IEAIREEAVS EMISSFVPPQ SLEEEWDIPG LEKQIREDFG 730 740 750 760 770 780 LALPIAQWLE KDETLHEETL HKRIIDEITK AYKAKEAKAD PKAMREVEKT LMLQLLDHHW 790 800 810 820 830 840 KEHLAAMDHL RQGIHLRGYA QKNPAQEYKR ESFELFTQML KRIKYELAAT LSKLEIATEE 850 860 870 880 890 900 QVAQQQRLYQ QSAPELQYHH AEMTALQPEK EVAVAEQEEA TQPFVRSQPK VGRNESCPCG 910 SGKKYKQCHG KLS

References

[1]

"Complete genome sequence of the Q-fever pathogen, Coxiella burnetii." Seshadri R., Paulsen I.T., Eisen J.A., Read T.D., Nelson K.E., Nelson W.C., Ward N.L., Tettelin H., Davidsen T.M., Beanan M.J., DeBoy R.T., Daugherty S.C., Brinkac L.M., Madupu R., Dodson R.J., Khouri H.M., Lee K.H., Carty H.A. , Scanlan D., Heinzen R.A., Thompson H.A., Samuel J.E., Fraser C.M., Heidelberg J.F. Proc. Natl. Acad. Sci. U.S.A. 100:5455-5460(2003) [PubMed: 12704232] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Nine Mile phase I / RSA 493.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE016828 Genomic DNA. Translation: AAO89711.1.
RefSeq	NP_819197.1.
3D structure databases
HSSP	HSSP built from PDB template 1M6N based on UniProtKB P28366.
ModBase	Search...
Genome annotation databases
GeneID	1208018.
GenomeReviews	Gene locus CBU_0147 in contig AE016828_GR.
KEGG	cbu:CBU_0147.
NMPDR	fig|227377.1.peg.141.
TIGR	CBU_0147.
Phylogenomic databases
HOGENOM	Q83F06.
Enzyme and pathway databases
BioCyc	CBUR227377:CBU_0147-MONOMER.
Family and domain databases
HAMAP	MF_01382. [Tree]
InterPro	IPR004027. SEC_C_motif. IPR000185. SecA. IPR011115. SecA_DEAD. IPR014018. SecA_motor_DEAD. IPR011130. SecA_PP_bd. IPR011116. SecA_SW. [Graphical view]
Gene3D	G3DSA:1.10.3060.10. SecA_SW. 1 hit.
Pfam	PF02810. SEC-C. 1 hit. PF07517. SecA_DEAD. 1 hit. PF01043. SecA_PP_bind. 1 hit. PF07516. SecA_SW. 1 hit. [Graphical view]
PRINTS	PR00906. SECA.
TIGRFAMs	TIGR00963. secA. 1 hit.
PROSITE	PS01312. SECA. 1 hit. PS51196. SECA_MOTOR_DEAD. 1 hit. [Graphical view]
ProDom	Q83F06. [Graphical view] [Entries sharing at least one domain]
BLOCKS	Search...
Other Resources
ProtoNet	Search...

Entry information

Entry name

SECA_COXBU

Accession

Primary (citable) accession number: Q83F06

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 26, 2008
Last sequence update:	June 1, 2003
Last modified:	July 22, 2008
This is version 39 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)