Reviewed, UniProtKB/Swiss-Prot Q83F11 (LPXC_COXBU)

Names and origin

Protein names

Recommended name:
    UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase
    EC=3.5.1.-
Alternative name(s):
    UDP-3-O-acyl-GlcNAc deacetylase

Gene names

Name:	lpxC
Ordered Locus Names:	CBU_0142

Organism

Coxiella burnetii [Complete proteome] [HAMAP]

Taxonomic identifier

777 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Legionellales › Coxiellaceae › Coxiella

Protein attributes

Sequence length	303 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell By similarity.
Catalytic activity	UDP-3-O-(3-hydroxytetradecanoyl)-N-acetylglucosamine + H(2)O = UDP-3-O-(3-hydroxytetradecanoyl)-glucosamine + acetate.
Pathway	Glycolipid biosynthesis; lipid (IV)A biosynthesis; lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-D-glucosamine: step 2/6.
Sequence similarities	Belongs to the lpxC family.

Ontologies

Keywords
Biological process	Lipid A biosynthesis Lipid synthesis
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	lipid A biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view
Molecule processing
	Chain	1 – 303	303	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase

Sequences

	Sequence		Length	Mass (Da)
	Q83F11-1 [UniParc]. Last modified June 1, 2003. Version 1. Checksum: 45B7E1D4D54E49DF	FASTA	303	33,514
	10 20 30 40 50 60 MIKQRTLKNV VRATGVGVHT GEKVYLTLRP APPNTGIIFC RTDLDPVVQI PARVNYIGDT 70 80 90 100 110 120 SLSTCLTKGD VRIATVEHLL SALAGVGVDN LYIDLTSPEL PIMDGSAGPF VFLIQSAGIE 130 140 150 160 170 180 EQNAPKEFIR IKQRVKIEEA DKSVMVEPYN GFKISFGIDF DHPLFNEHNQ NATLDFSSTS 190 200 210 220 230 240 YVKEVSRART FGFLSDYEFI RKNNLALGAS LDNALVLDEY KILNQDGLRY PDEFVKHKIL 250 260 270 280 290 300 DVIGDLYLLG RSLIGSFSGV KSGHTLNSQL LKQLLATKSA WEIVTFKDPS ELPFAYTPVA MTA

References

[1]

"Complete genome sequence of the Q-fever pathogen, Coxiella burnetii." Seshadri R., Paulsen I.T., Eisen J.A., Read T.D., Nelson K.E., Nelson W.C., Ward N.L., Tettelin H., Davidsen T.M., Beanan M.J., DeBoy R.T., Daugherty S.C., Brinkac L.M., Madupu R., Dodson R.J., Khouri H.M., Lee K.H., Carty H.A. , Scanlan D., Heinzen R.A., Thompson H.A., Samuel J.E., Fraser C.M., Heidelberg J.F. Proc. Natl. Acad. Sci. U.S.A. 100:5455-5460(2003) [PubMed: 12704232] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Nine Mile phase I / RSA 493.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE016828 Genomic DNA. Translation: AAO89706.1.
RefSeq	NP_819192.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	1208013.
GenomeReviews	Gene locus CBU_0142 in contig AE016828_GR.
KEGG	cbu:CBU_0142.
NMPDR	fig|227377.1.peg.136.
TIGR	CBU_0142.
Phylogenomic databases
HOGENOM	Q83F11.
Enzyme and pathway databases
BioCyc	CBUR227377:CBU_0142-MON.
Family and domain databases
HAMAP	MF_00388. [Tree]
InterPro	IPR004463. UDP-acyl_GlcNac_deAcase. IPR011334. UDP-acyl_GlcNac_deAcase_C. IPR015870. UDP-acyl_N-AcGlcN_deAcase_N. [Graphical view]
Gene3D	G3DSA:3.30.1700.10. UDP-acyl_N-AcGlcN_deAcase_C. 1 hit. G3DSA:3.30.230.20. UDP-acyl_N-AcGlcN_deAcase_N. 1 hit.
Pfam	PF03331. LpxC. 1 hit. [Graphical view]
ProDom	PD011499. Lipid_A_LpxC. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR00325. lpxC. 1 hit.
BLOCKS	Search...
Other Resources
ProtoNet	Search...

Entry information

Entry name

LPXC_COXBU

Accession

Primary (citable) accession number: Q83F11

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 25, 2003
Last sequence update:	June 1, 2003
Last modified:	July 22, 2008
This is version 29 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)