Reviewed, UniProtKB/Swiss-Prot Q83F94 (UBIC_COXBU)

Names and origin

Protein names

Recommended name:
    Probable chorismate--pyruvate lyase
      Short name=CL
      Short name=CPL
    EC=4.1.3.40

Gene names

Name:	ubiC
Ordered Locus Names:	CBU_0054

Organism

Coxiella burnetii [Complete proteome] [HAMAP]

Taxonomic identifier

777 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Legionellales › Coxiellaceae › Coxiella

Protein attributes

Sequence length	185 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4-hydroxybenzoate (4HB) for the ubiquinone pathway By similarity.
Catalytic activity	Chorismate = 4-hydroxybenzoate + pyruvate.
Pathway	Cofactor biosynthesis; ubiquinone biosynthesis.
Subcellular location	CytoplasmBy similarity.
Sequence similarities	Belongs to the ubiC family.

Ontologies

Keywords
Biological process	Ubiquinone biosynthesis
Cellular component	Cytoplasm
Ligand	Pyruvate
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	pyruvate biosynthetic process Inferred from electronic annotation. Source: HAMAP ubiquinone biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: HAMAP
Molecular function	chorismate lyase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view
Molecule processing
	Chain	1 – 185	185	Probable chorismate--pyruvate lyase
Sites
	Binding site	75	1	Substrate By similarity
	Binding site	113	1	Substrate; via amide nitrogen By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q83F94-1 [UniParc]. Last modified June 1, 2003. Version 1. Checksum: 092F5FED72D6C720	FASTA	185	21,536
	10 20 30 40 50 60 MKKQLFWAPQ NEIPSTLWTA NERSWLTHPG SLTQRLRKTT DGQIQHHLLR EVFDAPVDEE 70 80 90 100 110 120 TQLLGISQPE LALIREIEWR YFESLWVAGR VVIPKKTLER EGSPLNHIGE RSLGDILFAN 130 140 150 160 170 180 AKFTRGDLEF RQITADHPYY FYVKEIANGS CIWARRSLFY FERDPLLVSE IFSPALFLES SVSND

References

[1]

"Complete genome sequence of the Q-fever pathogen, Coxiella burnetii." Seshadri R., Paulsen I.T., Eisen J.A., Read T.D., Nelson K.E., Nelson W.C., Ward N.L., Tettelin H., Davidsen T.M., Beanan M.J., DeBoy R.T., Daugherty S.C., Brinkac L.M., Madupu R., Dodson R.J., Khouri H.M., Lee K.H., Carty H.A. , Scanlan D., Heinzen R.A., Thompson H.A., Samuel J.E., Fraser C.M., Heidelberg J.F. Proc. Natl. Acad. Sci. U.S.A. 100:5455-5460(2003) [PubMed: 12704232] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Nine Mile phase I / RSA 493.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE016828 Genomic DNA. Translation: AAO89621.1.
RefSeq	NP_819107.1.
3D structure databases
HSSP	HSSP built from PDB template 1G1B based on UniProtKB P26602.
ModBase	Search...
Genome annotation databases
GeneID	1207916.
GenomeReviews	Gene locus CBU_0054 in contig AE016828_GR.
KEGG	cbu:CBU_0054.
NMPDR	fig|227377.1.peg.51.
TIGR	CBU_0054.
Phylogenomic databases
HOGENOM	Q83F94.
Enzyme and pathway databases
BioCyc	CBUR227377:CBU_0054-MON.
Family and domain databases
HAMAP	MF_01632. [Tree]
InterPro	IPR007440. Chor_lyase. [Graphical view]
Pfam	PF04345. Chor_lyase. 1 hit. [Graphical view]
ProDom	Q83F94. [Graphical view] [Entries sharing at least one domain]
BLOCKS	Search...
Other Resources
ProtoNet	Search...

Entry information

Entry name

UBIC_COXBU

Accession

Primary (citable) accession number: Q83F94

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 27, 2006
Last sequence update:	June 1, 2003
Last modified:	July 22, 2008
This is version 31 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)