Reviewed, UniProtKB/Swiss-Prot Q83FA4 (HEMH_COXBU)

Names and origin

Protein names

Recommended name:
    Ferrochelatase
    EC=4.99.1.1
Alternative name(s):
    Protoheme ferro-lyase
    Heme synthetase

Gene names

Name:	hemH
Ordered Locus Names:	CBU_0042

Organism

Coxiella burnetii [Complete proteome] [HAMAP]

Taxonomic identifier

777 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Legionellales › Coxiellaceae › Coxiella

Protein attributes

Sequence length	343 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the ferrous insertion into protoporphyrin IX.
Catalytic activity	Protoheme + 2 H(+) = protoporphyrin + Fe(2+).
Pathway	Porphyrin metabolism; protoheme biosynthesis; protoheme from protoporphyrin-IX: step 1/1.
Subcellular location	CytoplasmBy similarity.
Sequence similarities	Belongs to the ferrochelatase family.

Ontologies

Keywords
Biological process	Heme biosynthesis Porphyrin biosynthesis
Cellular component	Cytoplasm
Ligand	Iron Metal-binding
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	heme biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: HAMAP
Molecular function	ferrochelatase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view
Molecule processing
	Chain	1 – 343	343	Ferrochelatase
Sites
	Metal binding	193	1	Iron By similarity
	Metal binding	295	1	Iron By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q83FA4-1 [UniParc]. Last modified June 1, 2003. Version 1. Checksum: A5DA2B98DD234FDE	FASTA	343	39,333
	10 20 30 40 50 60 MAVKNNNKIG VLLINLGTPD EPSVPAVRRY LRQFLSDPKV IDVPSLVRWI IVHLCILPFR 70 80 90 100 110 120 PKRSAKLYQK IWMPEGSPLL VYSEMLRERV GETLGDDFCV ALGMRYGKPS IETALKKLQE 130 140 150 160 170 180 AQCRQLIVLP LFPQYSTSTT ASALEEVRAK NSFKEMTVID RFFEEPHYID SMTTLIHENL 190 200 210 220 230 240 NEFQPDYFLF SYHGLPERHL VKSGCQLAIC NRKNNCSPIS SSNENCYRAQ CFETSRLIAK 250 260 270 280 290 300 KLNLTDQQYG VAFQSRLGRA KWIEPYTDKY LIELSKKGIK KLMVVCPSFP VDCLETLEEI 310 320 330 340 GIRAQSQWQR LDGETLKLIP SLNAHPQWVN AIAKMAKKSL QLF

References

[1]

"Complete genome sequence of the Q-fever pathogen, Coxiella burnetii." Seshadri R., Paulsen I.T., Eisen J.A., Read T.D., Nelson K.E., Nelson W.C., Ward N.L., Tettelin H., Davidsen T.M., Beanan M.J., DeBoy R.T., Daugherty S.C., Brinkac L.M., Madupu R., Dodson R.J., Khouri H.M., Lee K.H., Carty H.A. , Scanlan D., Heinzen R.A., Thompson H.A., Samuel J.E., Fraser C.M., Heidelberg J.F. Proc. Natl. Acad. Sci. U.S.A. 100:5455-5460(2003) [PubMed: 12704232] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Nine Mile phase I / RSA 493.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE016828 Genomic DNA. Translation: AAO89611.1.
RefSeq	NP_819097.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	1207904.
GenomeReviews	Gene locus CBU_0042 in contig AE016828_GR.
KEGG	cbu:CBU_0042.
NMPDR	fig|227377.1.peg.41.
TIGR	CBU_0042.
Phylogenomic databases
HOGENOM	Q83FA4.
Enzyme and pathway databases
BioCyc	CBUR227377:CBU_0042-MON.
Family and domain databases
HAMAP	MF_00323. [Tree]
InterPro	IPR001015. Ferrochelatase. [Graphical view]
PANTHER	PTHR11108. Ferrochelatase. 1 hit.
Pfam	PF00762. Ferrochelatase. 1 hit. [Graphical view]
ProDom	PD002792. Ferrochelatase. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR00109. hemH. 1 hit.
PROSITE	PS00534. FERROCHELATASE. 1 hit. [Graphical view]
BLOCKS	Search...
Other Resources
ProtoNet	Search...

Entry information

Entry name

HEMH_COXBU

Accession

Primary (citable) accession number: Q83FA4

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 16, 2004
Last sequence update:	June 1, 2003
Last modified:	July 22, 2008
This is version 37 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)