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Reviewed, UniProtKB/Swiss-Prot Q86TH1 (ATL2_HUMAN)

Last modified July 22, 2008. Version 37. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    ADAMTS-like protein 2
      Short name(s)=ADAMTSL-2
Gene names
Name: ADAMTSL2
Synonyms: KIAA0605
OrganismHomo sapiens (Human)
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

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Protein attributes

Sequence length951 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level.

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General annotation (Comments)

Subcellular location

SecretedPotential.

Sequence similarities

Contains 1 PLAC domain.

Contains 7 TSP type-1 domains.

Caution

Although strongly similar to members of the ADAMTS family it lacks the metalloprotease and disintegrin-like domains which are typical of that family.

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Ontologies

Keywords

   Cellular componentSecreted
   DomainRepeat
Signal
   PTMGlycoprotein

Gene Ontology (GO)

None. [Check GOA]

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical view

Molecule processing

Signal peptide1 – 2222 Potential
Chain23 – 951929ADAMTS-like protein 2

Regions

Domain47 – 10660TSP type-1 1
Domain564 – 61855TSP type-1 2
Domain622 – 68665TSP type-1 3
Domain688 – 73649TSP type-1 4
Domain737 – 79559TSP type-1 5
Domain797 – 85155TSP type-1 6
Domain853 – 90856TSP type-1 7
Domain912 – 95039PLAC

Amino acid modifications

Glycosylation871N-linked (GlcNAc...) Potential
Glycosylation3671N-linked (GlcNAc...) Potential
Glycosylation4281N-linked (GlcNAc...) Potential
Glycosylation4751N-linked (GlcNAc...) Potential
Glycosylation5111N-linked (GlcNAc...) Potential
Glycosylation5241N-linked (GlcNAc...) Potential
Glycosylation5331N-linked (GlcNAc...) Potential
Glycosylation5441N-linked (GlcNAc...) Potential
Glycosylation7311N-linked (GlcNAc...) Potential
Glycosylation8071N-linked (GlcNAc...) Potential
Disulfide bond59 ↔ 100 By similarity
Disulfide bond63 ↔ 105 By similarity
Disulfide bond74 ↔ 90 By similarity

Experimental info

Sequence conflict591C → F in BAA25531. Ref.1
Sequence conflict3641V → I in BAA25531. Ref.1

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Sequences

Sequence LengthMass (Da)Tools
Q86TH1-1 [UniParc].

Last modified June 1, 2003. Version 1.
Checksum: 93A9B0DC5BAB6CC7

FASTA951104,621
        10         20         30         40         50         60 
MDGRWQCSCW AWFLLVLAVV AGDTVSTGST DNSPTSNSLE GGTDATAFWW GEWTKWTACS 

        70         80         90        100        110        120 
RSCGGGVTSQ ERHCLQQRRK SVPGPGNRTC TGTSKRYQLC RVQECPPDGR SFREEQCVSF 

       130        140        150        160        170        180 
NSHVYNGRTH QWKPLYPDDY VHISSKPCDL HCTTVDGQRQ LMVPARDGTS CKLTDLRGVC 

       190        200        210        220        230        240 
VSGKCEPIGC DGVLFSTHTL DKCGICQGDG SSCTHVTGNY RKGNAHLGYS LVTHIPAGAR 

       250        260        270        280        290        300 
DIQIVERKKS ADVLALADEA GYYFFNGNYK VDSPKNFNIA GTVVKYRRPM DVYETGIEYI 

       310        320        330        340        350        360 
VAQGPTNQGL NVMVWNQNGK SPSITFEYTL LQPPHESRPQ PIYYGFSESA ESQGLDGAGL 

       370        380        390        400        410        420 
MGFVPHNGSL YGQASSERLG LDNRLFGHPG LDMELGPSQG QETNEVCEQA GGGACEGPPR 

       430        440        450        460        470        480 
GKGFRDRNVT GTPLTGDKDD EEVDTHFASQ EFFSANAISD QLLGAGSDLK DFTLNETVNS 

       490        500        510        520        530        540 
IFAQGAPRSS LAESFFVDYE ENEGAGPYLL NGSYLELSSD RVANSSSEAP FPNVSTSLLT 

       550        560        570        580        590        600 
SAGNRTHKAR TRPKARKQGV SPADMYRWKL SSHEPCSATC TTGVMSAYAM CVRYDGVEVD 

       610        620        630        640        650        660 
DSYCDALTRP EPVHEFCAGR ECQPRWETSS WSECSRTCGE GYQFRVVRCW KMLSPGFDSS 

       670        680        690        700        710        720 
VYSDLCEAAE AVRPEERKTC RNPACGPQWE MSEWSECTAK CGERSVVTRD IRCSEDEKLC 

       730        740        750        760        770        780 
DPNTRPVGEK NCTGPPCDRQ WTVSDWGPCS GSCGQGRTIR HVYCKTSDGR VVPESQCQME 

       790        800        810        820        830        840 
TKPLAIHPCG DKNCPAHWLA QDWERCNTTC GRGVKKRLVL CMELANGKPQ TRSGPECGLA 

       850        860        870        880        890        900 
KKPPEESTCF ERPCFKWYTS PWSECTKTCG VGVRMRDVKC YQGTDIVRGC DPLVKPVGRQ 

       910        920        930        940        950 
ACDLQPCPTE PPDDSCQDQP GTNCALAIKV NLCGHWYYSK ACCRSCRPPH S

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References

[1]"Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."
Nagase T., Ishikawa K., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
DNA Res. 5:31-39(1998) [PubMed: 9628581] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: PNS.

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Cross-references

Sequence databases

AB011177 mRNA. Translation: BAA25531.2. Different initiation.
BC050544 mRNA. Translation: AAH50544.1.
PIRT00260.
RefSeqNP_055509.2.
UniGeneHs.522543

3D structure databases

HSSPHSSP built from PDB template 1LSL based on UniProtKB P07996.
ModBaseSearch...

Genome annotation databases

EnsemblENSG00000197859. Homo sapiens. [Contig view]
GeneID9719.
KEGGhsa:9719.

Organism-specific databases

HGNCHGNC:14631. ADAMTSL2.
PharmGKBPA134920655.
HUGESearch...
GenAtlasSearch...
GeneCardsSearch...
GeneLynxSearch...

Phylogenomic databases

HOVERGENQ86TH1.

Gene expression databases

CleanExHS_ADAMTSL2.
GermOnlineENSG00000197859. Homo sapiens.

Family and domain databases

InterProIPR010294. ADAM_spacer1.
IPR013273. Peptidase_M12B_ADAM-TS.
IPR010909. PLAC.
IPR000884. TSP1.
[Graphical view]
PfamPF05986. ADAM_spacer1. 1 hit.
PF08686. PLAC. 1 hit.
PF00090. TSP_1. 4 hits.
[Graphical view]
PRINTSPR01857. ADAMTSFAMILY.
SMARTSM00209. TSP1. 7 hits.
[Graphical view]
PROSITEPS50900. PLAC. 1 hit.
PS50092. TSP1. 4 hits.
[Graphical view]
ProDomQ86TH1.
[Graphical view] [Entries sharing at least one domain]
BLOCKSSearch...

Other Resources

ProtoNetSearch...

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Entry information

Entry nameATL2_HUMAN
AccessionPrimary (citable) accession number: Q86TH1
Secondary accession number(s): O60345
Entry history
Integrated into UniProtKB/Swiss-Prot: September 19, 2006
Last sequence update: June 1, 2003
Last modified: July 22, 2008
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

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Relevant documents

Human chromosome 9

Human chromosome 9: entries, gene names and cross-references to MIM

UniProtKB secondary accession numbers

Index of UniProtKB secondary accession numbers

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents