Reviewed, UniProtKB/Swiss-Prot Q86TW2 (ADCK1_HUMAN)

Names and origin

Protein names

Recommended name:
    Uncharacterized aarF domain-containing protein kinase 1
    EC=2.7.11.-

Gene names

Name:

ADCK1

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	530 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	The function of this protein is not yet clear. It is not known if it has protein kinase activity and what type of substrate it would phosphorylate (Ser, Thr or Tyr).
Subcellular location	SecretedPotential.
Sequence similarities	Belongs to the protein kinase superfamily. ADCK protein kinase family. Contains 1 protein kinase domain.

Ontologies

Keywords
Cellular component	Secreted
Coding sequence diversity	Alternative splicing
Domain	Signal
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Serine/threonine-protein kinase Transferase
PTM	Phosphoprotein
Gene Ontology (GO)
None. [Check GOA]

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q86TW2-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q86TW2-2)

The sequence of this isoform differs from the canonical sequence as follows:
     74-80: Missing.

Notes: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view
Molecule processing
	Signal peptide	1 – 17	17	Potential
	Chain	18 – 530	513	Uncharacterized aarF domain-containing protein kinase 1
Regions
	Domain	155 – 467	313	Protein kinase
	Nucleotide binding	161 – 169	9	ATP By similarity
Sites
	Active site	315	1	Proton acceptor By similarity
	Binding site	183	1	ATP By similarity
Amino acid modifications
	Modified residue	441	1	Phosphothreonine
Natural variations
	Alternative sequence	74 – 80	7	Missing in isoform 2.

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified October 3, 2006. Version 2. Checksum: CBB1DFA87D0F41CF	FASTA	530	60,577
	10 20 30 40 50 60 MARKALKLAS WTSMALAASG IYFYSNKYLD PNDFGAVRVG RAVATTAVIS YDYLTSLKSV 70 80 90 100 110 120 PYGSEEYLQL RSKSWPVFLQ VHLRSARRLC ELCCANRGTF IKVGQHLGAL DYLLPEEYTS 130 140 150 160 170 180 TLKVLHSQAP QSSMQEIRQV IREDLGKEIH DLFQSFDDTP LGTASLAQVH KAVLHDGRTV 190 200 210 220 230 240 AVKVQHPKVR AQSSKDILLM EVLVLAVKQL FPEFEFMWLV DEAKKNLPLE LDFLNEGRNA 250 260 270 280 290 300 EKVSQMLRHF DFLKVPRIHW DLSTERVLLM EFVDGGQVND RDYMERNKID VNEISRHLGK 310 320 330 340 350 360 MYSEMIFVNG FVHCDPHPGN VLVRKHPGTG KAEIVLLDHG LYQMLTEEFR LNYCHLWQSL 370 380 390 400 410 420 IWTDMKRVKE YSQRLGAGDL YPLFACMLTA RSWDSVNRGI SQAPVTATED LEIRNNAANY 430 440 450 460 470 480 LPQISHLLNH VPRQMLLILK TNDLLRGIEA ALGTRASASS FLNMSRCCIR ALAEHKKKNT 490 500 510 520 530 CSFFRRTQIS FSEAFNLWQI NLHELILRVK GLKLADRVLA LICWLFPAPL
	Isoform 2 [UniParc]. Checksum: 94BEF675D2642ADB		523	59,719
	10 20 30 40 50 60 MARKALKLAS WTSMALAASG IYFYSNKYLD PNDFGAVRVG RAVATTAVIS YDYLTSLKSV 70 80 90 100 110 120 PYGSEEYLQL RSKVHLRSAR RLCELCCANR GTFIKVGQHL GALDYLLPEE YTSTLKVLHS 130 140 150 160 170 180 QAPQSSMQEI RQVIREDLGK EIHDLFQSFD DTPLGTASLA QVHKAVLHDG RTVAVKVQHP 190 200 210 220 230 240 KVRAQSSKDI LLMEVLVLAV KQLFPEFEFM WLVDEAKKNL PLELDFLNEG RNAEKVSQML 250 260 270 280 290 300 RHFDFLKVPR IHWDLSTERV LLMEFVDGGQ VNDRDYMERN KIDVNEISRH LGKMYSEMIF 310 320 330 340 350 360 VNGFVHCDPH PGNVLVRKHP GTGKAEIVLL DHGLYQMLTE EFRLNYCHLW QSLIWTDMKR 370 380 390 400 410 420 VKEYSQRLGA GDLYPLFACM LTARSWDSVN RGISQAPVTA TEDLEIRNNA ANYLPQISHL 430 440 450 460 470 480 LNHVPRQMLL ILKTNDLLRG IEAALGTRAS ASSFLNMSRC CIRALAEHKK KNTCSFFRRT 490 500 510 520 QISFSEAFNL WQINLHELIL RVKGLKLADR VLALICWLFP APL

References

[1]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Skin.
[2]	"Full-length cDNA libraries and normalization." Li W.B., Gruber C., Jessee J., Polayes D. Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-321 (ISOFORM 1). Tissue: Placenta.
[3]	"Automated phosphoproteome analysis for cultured cancer cells by two-dimensional nanoLC-MS using a calcined titania/C18 biphasic column." Imami K., Sugiyama N., Kyono Y., Tomita M., Ishihama Y. Anal. Sci. 24:161-166(2008) [PubMed: 18187866] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-441, MASS SPECTROMETRY.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BC058906 mRNA. Translation: AAH58906.1. BX248292 mRNA. Translation: CAD62620.1. Different initiation.
RefSeq	NP_065154.2.
UniGene	Hs.413208
3D structure databases
ModBase	Search...
Protein-protein interaction databases
IntAct	Q86TW2.
Genome annotation databases
Ensembl	ENSG00000063761. Homo sapiens. [Contig view]
GeneID	57143.
KEGG	hsa:57143.
Organism-specific databases
HGNC	HGNC:19038. ADCK1.
PharmGKB	PA134861355.
GenAtlas	Search...
GeneCards	Search...
GeneLynx	Search...
Phylogenomic databases
HOVERGEN	Q86TW2.
Gene expression databases
ArrayExpress	Q86TW2.
CleanEx	HS_ADCK1.
Family and domain databases
InterPro	IPR004147. ABC_1. IPR000719. Prot_kinase_core. IPR017441. Protein_kinase_ATP_bd_CS. [Graphical view]
Pfam	PF03109. ABC1. 1 hit. [Graphical view]
ProDom	PD000001. Prot_kinase. 1 hit. [Graphical view] [Entries sharing at least one domain]
PROSITE	PS00107. PROTEIN_KINASE_ATP. False negative. PS50011. PROTEIN_KINASE_DOM. False negative. [Graphical view]
BLOCKS	Search...
Other Resources
ProtoNet	Search...

Entry information

Entry name

ADCK1_HUMAN

Accession

Primary (citable) accession number: Q86TW2
Secondary accession number(s): Q6PD65

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 3, 2006
Last sequence update:	October 3, 2006
Last modified:	July 22, 2008
This is version 29 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)