Reviewed, UniProtKB/Swiss-Prot Q86V24 (ADR2_HUMAN)

Names and origin

Protein names

Recommended name:
    Adiponectin receptor protein 2
Alternative name(s):
    Progestin and adipoQ receptor family member II

Gene names

Name:	ADIPOR2
Synonyms:	PAQR2

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	386 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Receptor for globular and full-length adiponectin (APM1), an essential hormone secreted by adipocytes that acts as an antidiabetic. Probably involved in metabolic pathways that regulate lipid metabolism such as fatty acid oxidation. Mediates increased AMPK, PPARA ligand activity, fatty acid oxidation and glucose uptake by adiponectin. Has some intermediate-affinity receptor activity for both globular and full-length adiponectin.
Subunit structure	May form homo and heteromultimers.
Subcellular location	Membrane; Multi-pass membrane protein. Note= Localized to the cell membrane and intracellular organelles.
Tissue specificity	Highly expressed in skeletal muscle, liver and placenta. Weakly expressed in brain, heart, colon, spleen, kidney, thymus, small intestine, peripheral blood leukocytes and lung.
Sequence similarities	Belongs to the ADIPOR family.

Ontologies

Keywords
Biological process	Fatty acid metabolism Lipid metabolism
Cellular component	Membrane
Domain	Transmembrane
Molecular function	Receptor
Gene Ontology (GO)
Biological process	fatty acid oxidation Ref.3 Inferred from sequence or structural similarity. Source: UniProtKB hormone-mediated signaling Ref.3 Inferred from sequence or structural similarity. Source: UniProtKB
Molecular function	hormone binding Ref.3 Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
APPL1	Q9UKG1	3	EBI-1769445,EBI-741243

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view
Molecule processing
	Chain	1 – 386	386	Adiponectin receptor protein 2
Regions
	Topological domain	1 – 147	147	Cytoplasmic Potential
	Transmembrane	148 – 168	21	1 Potential
	Topological domain	169 – 181	13	Extracellular Potential
	Transmembrane	182 – 202	21	2 Potential
	Topological domain	203 – 220	18	Cytoplasmic Potential
	Transmembrane	221 – 241	21	3 Potential
	Topological domain	242 – 245	4	Extracellular Potential
	Transmembrane	246 – 266	21	4 Potential
	Topological domain	267 – 278	12	Cytoplasmic Potential
	Transmembrane	279 – 299	21	5 Potential
	Topological domain	300 – 307	8	Extracellular Potential
	Transmembrane	308 – 328	21	6 Potential
	Topological domain	329 – 342	14	Cytoplasmic Potential
	Transmembrane	343 – 363	21	7 Potential
	Topological domain	364 – 386	23	Extracellular Potential
Experimental info
	Sequence conflict	158	1	F → S in BAB15062. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q86V24-1 [UniParc]. Last modified June 1, 2003. Version 1. Checksum: B3B0FF0BBF118AA1	FASTA	386	43,884
	10 20 30 40 50 60 MNEPTENRLG CSRTPEPDIR LRKGHQLDGT RRGDNDSHQG DLEPILEASV LSSHHKKSSE 70 80 90 100 110 120 EHEYSDEAPQ EDEGFMGMSP LLQAHHAMEK MEEFVCKVWE GRWRVIPHDV LPDWLKDNDF 130 140 150 160 170 180 LLHGHRPPMP SFRACFKSIF RIHTETGNIW THLLGCVFFL CLGIFYMFRP NISFVAPLQE 190 200 210 220 230 240 KVVFGLFFLG AILCLSFSWL FHTVYCHSEG VSRLFSKLDY SGIALLIMGS FVPWLYYSFY 250 260 270 280 290 300 CNPQPCFIYL IVICVLGIAA IIVSQWDMFA TPQYRGVRAG VFLGLGLSGI IPTLHYVISE 310 320 330 340 350 360 GFLKAATIGQ IGWLMLMASL YITGAALYAA RIPERFFPGK CDIWFHSHQL FHIFVVAGAF 370 380 VHFHGVSNLQ EFRFMIGGGC SEEDAL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Colon, Hippocampus and Trachea.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Uterus.
[3]	"Cloning of adiponectin receptors that mediate antidiabetic metabolic effects." Yamauchi T., Kamon J., Ito Y., Tsuchida A., Yokomizo T., Kita S., Sugiyama T., Miyagishi M., Hara K., Tsunoda M., Murakami K., Ohteki T., Uchida S., Takekawa S., Waki H., Tsuno N.H., Shibata Y., Terauchi Y. , Froguel P., Tobe K., Koyasu S., Taira K., Kitamura T., Shimizu T., Nagai R., Kadowaki T. Nature 423:762-769(2003) [PubMed: 12802337] [Abstract] Cited for: FUNCTION, SUBUNIT, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
+	Additional computationally mapped references.

Web resources

Wikipedia

Adiponectin entry

Cross-references

Sequence databases
EMBLGenBankDDBJ	AK025085 mRNA. Translation: BAB15062.1. Different initiation. AK127196 mRNA. Translation: BAC86881.1. AK128511 mRNA. Translation: BAC87473.1. BC051858 mRNA. Translation: AAH51858.1.
RefSeq	NP_078827.2.
UniGene	Hs.371642 Hs.645880
3D structure databases
ModBase	Search...
Protein-protein interaction databases
IntAct	Q86V24.
Genome annotation databases
Ensembl	ENSG00000006831. Homo sapiens. [Contig view]
GeneID	79602.
KEGG	hsa:79602.
Organism-specific databases
H-InvDB	HIX0010320.
HGNC	HGNC:24041. ADIPOR2.
MIM	607946. gene.
PharmGKB	PA128394711.
GenAtlas	Search...
GeneCards	Search...
Phylogenomic databases
HOGENOM	Q86V24.
HOVERGEN	Q86V24.
Gene expression databases
ArrayExpress	Q86V24.
CleanEx	HS_ADIPOR2.
GermOnline	ENSG00000006831. Homo sapiens.
Family and domain databases
InterPro	IPR004254. HlyIII_related. [Graphical view]
PANTHER	PTHR20855. HlyIII_related. 1 hit.
Pfam	PF03006. HlyIII. 1 hit. [Graphical view]
ProDom	Q86V24. [Graphical view] [Entries sharing at least one domain]
BLOCKS	Search...
Other Resources
LinkHub	Q86V24.
SOURCE	Search...
ProtoNet	Search...

Entry information

Entry name

ADR2_HUMAN

Accession

Primary (citable) accession number: Q86V24
Secondary accession number(s): Q9H737

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 14, 2003
Last sequence update:	June 1, 2003
Last modified:	July 22, 2008
This is version 45 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)