Reviewed, UniProtKB/Swiss-Prot Q86W74 (ANR46_HUMAN)

Names and origin

Protein names

Recommended name:
    Ankyrin repeat domain-containing protein 46
Alternative name(s):
    Ankyrin repeat small protein
      Short name=ANK-S

Gene names

Name:

ANKRD46

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	232 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Subcellular location	Membrane; Single-pass membrane proteinPotential.
Sequence similarities	Contains 4 ANK repeats.

Ontologies

Keywords
Cellular component	Membrane
Coding sequence diversity	Alternative splicing
Domain	ANK repeat Repeat Transmembrane
Gene Ontology (GO)
None. [Check GOA]

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q86W74-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q86W74-2)

The sequence of this isoform differs from the canonical sequence as follows:
     213-232: RRTLRLGSFARQDRSRIQAI → VSGVLPFVENQPELVH

Notes: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view
Molecule processing
	Chain	1 – 232	232	Ankyrin repeat domain-containing protein 46
Regions
	Transmembrane	190 – 210	21	Potential
	Repeat	11 – 40	30	ANK 1
	Repeat	44 – 73	30	ANK 2
	Repeat	77 – 103	27	ANK 3
	Repeat	107 – 138	32	ANK 4
Natural variations
	Alternative sequence	213 – 232	20	RRTLR…RIQAI → VSGVLPFVENQPELVH in isoform 2.

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified June 1, 2003. Version 1. Checksum: 63A3088747ED7E9A	FASTA	232	25,967
	10 20 30 40 50 60 MSYVFVNDSS QTNVPLLQAC IDGDFNYSKR LLESGFDPNI RDSRGRTGLH LAAARGNVDI 70 80 90 100 110 120 CQLLHKFGAD LLATDYQGNT ALHLCGHVDT IQFLVSNGLK IDICNHQGAT PLVLAKRRGV 130 140 150 160 170 180 NKDVIRLLES LEEQEVKGFN RGTHSKLETM QTAESESAME SHSLLNPNLQ QGEGVLSSFR 190 200 210 220 230 TTWQEFVEDL GFWRVLLLIF VIALLSLGIA YYRRTLRLGS FARQDRSRIQ AI
	Isoform 2 [UniParc]. Checksum: F49A43CE49A28A0C		228	25,330
	10 20 30 40 50 60 MSYVFVNDSS QTNVPLLQAC IDGDFNYSKR LLESGFDPNI RDSRGRTGLH LAAARGNVDI 70 80 90 100 110 120 CQLLHKFGAD LLATDYQGNT ALHLCGHVDT IQFLVSNGLK IDICNHQGAT PLVLAKRRGV 130 140 150 160 170 180 NKDVIRLLES LEEQEVKGFN RGTHSKLETM QTAESESAME SHSLLNPNLQ QGEGVLSSFR 190 200 210 220 TTWQEFVEDL GFWRVLLLIF VIALLSLGIA YYVSGVLPFV ENQPELVH

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A novel ankyrin-repeat containing gene expressed in SAMP8 hippocampus." Yamamura N., Koike N., Nomura Y., Sakaki Y., Tashiro T., Furihata C. Submitted (DEC-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
[2]	The German cDNA consortium Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Lymph node.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2). Tissue: Placenta and Skin.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AB077205 mRNA. Translation: BAD23947.1. AL832842 mRNA. Translation: CAI46169.1. BC050396 mRNA. Translation: AAH50396.1. BC060843 mRNA. Translation: AAH60843.1.
RefSeq	NP_940683.1.
UniGene	Hs.530199
3D structure databases
HSSP	HSSP built from PDB template 1OY3 based on UniProtKB Q60778.
ModBase	Search...
Genome annotation databases
Ensembl	ENSG00000186106. Homo sapiens. [Contig view]
GeneID	157567.
KEGG	hsa:157567.
Organism-specific databases
HGNC	HGNC:27229. ANKRD46.
PharmGKB	PA142672613.
GenAtlas	Search...
GeneCards	Search...
Phylogenomic databases
HOGENOM	Q86W74.
HOVERGEN	Q86W74.
Gene expression databases
ArrayExpress	Q86W74.
CleanEx	HS_ANKRD46.
GermOnline	ENSG00000186106. Homo sapiens.
Family and domain databases
InterPro	IPR002110. ANK. [Graphical view]
Gene3D	G3DSA:1.25.40.20. ANK. 1 hit.
Pfam	PF00023. Ank. 4 hits. [Graphical view]
PRINTS	PR01415. ANKYRIN.
SMART	SM00248. ANK. 3 hits. [Graphical view]
PROSITE	PS50297. ANK_REP_REGION. 1 hit. PS50088. ANK_REPEAT. 2 hits. [Graphical view]
ProDom	Q86W74. [Graphical view] [Entries sharing at least one domain]
BLOCKS	Search...
Other Resources
ProtoNet	Search...

Entry information

Entry name

ANR46_HUMAN

Accession

Primary (citable) accession number: Q86W74
Secondary accession number(s): Q6P9B7

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 27, 2006
Last sequence update:	June 1, 2003
Last modified:	July 22, 2008
This is version 37 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)