Unreviewed, UniProtKB/TrEMBL Q89770 (Q89770_9PARA)

Names and origin

Protein names	Recommended name:     Hemagglutinin-neuraminidase RuleBase RU003717V0     EC=3.2.1.18
Organism	Human parainfluenza virus 3 EMBL CAA81294.1
Taxonomic identifier	11216 [NCBI]
Taxonomic lineage	Viruses › ssRNA negative-strand viruses › Mononegavirales › Paramyxoviridae › Paramyxovirinae › Respirovirus

Protein attributes

Sequence length	572 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Attaches the virus to sialic acid-containing cell receptors and thereby initiating infection. Binding of HN protein to the receptor induces a conformational change that allows the F protein to trigger virion/cell membranes fusion By similarity. RuleBase RU003717V0 Neuraminidase activity ensures the efficient spread of the virus by dissociating the mature virions from the neuraminic acid containing glycoproteins By similarity. RuleBase RU003717V0
Catalytic activity	Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates. RuleBase RU003717V0
Sequence similarities	Belongs to the paramyxoviruses hemagglutinin-neuraminidase family. RuleBase RU004216V0

Ontologies

Keywords
Cellular component	Envelope protein RuleBase RU004216V0 Spearmint SPM000665 Membrane Virion
Domain	Transmembrane Spearmint SPM000665 RuleBase RU003717V0
Molecular function	Hemagglutinin RuleBase RU004216V0 Spearmint SPM000665 Hydrolase RuleBase RU003717V0
Gene Ontology (GO)
Biological process	viral infectious cycle Inferred from electronic annotation. Source: InterPro
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW viral envelope Inferred from electronic annotation. Source: InterPro
Molecular function	exo-alpha-sialidase activity Inferred from electronic annotation. Source: InterPro host cell surface receptor binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q89770-1 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: 52772B365FD4CC82	FASTA	572	64,278
	10 20 30 40 50 60 MEYWKHTNHG KDAGNELETS MATNGNKLTN KITYILWTII LVLLSIVFII VLINSIKSEK 70 80 90 100 110 120 AHESLLQDIN NEFMEITEKI QMASDNTNDL IQSGVNTRLL TIQSHVQNYI PISLTQQMSD 130 140 150 160 170 180 LRKFISEITI RNDNQEVLPQ RITHDVGIKP LNPDDFWRCT SGLPSLMKTP KIRLMPGPGL 190 200 210 220 230 240 LAMPTTVDGC IRTPSLVIND LIYAYTSNLI TRGCQDIGKS YQVLQIGIIT VNSDLVPDLN 250 260 270 280 290 300 PRISHTFNIN DNRKSCSLAL LNTDVYQLCS TPKVDERSDY ASSGIEDIVL DIVNYDGSIS 310 320 330 340 350 360 TTRFKNNNIS FDQPYAALYP SVGPGIYYKG KIIFLGYGGL EHPINENVIC NTTGCPGKTQ 370 380 390 400 410 420 RDCNQASHSP WFSDRRMVNS IIVVDKGLNS IPKLKVWTIS MRQNYWGSEG RLLLLGNKIY 430 440 450 460 470 480 IYTRSTSWHS KLQLGIIDIT DYSDIRIKWT WHNVLSRPGN NECPWGHSCP DGCITGVYTD 490 500 510 520 530 540 AYPLNPTGSI VSSVILDSQK SRVNPVITYS TATERVNELA IRNRTLSAGY TTTSCITHYN 550 560 570 KGYCFHIVEI NQKSLNTLQP MLFKTEVPKS CS

References

[1]	"A prototype recombinant vaccine against respiratory syncytial virus and parainfluenza virus type 3." Du R.P., Jackson G.E., Wyde P.R., Yan W.Y., Wang Q., Gisonni L., Sanhueza S.E., Klein M.H., Ewasyshyn M.E. Biotechnology (N.Y.) 12:813-818(1994) [PubMed: 7765021] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.
[2]	Du R. Submitted (SEP-1993) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.

Cross-references

Sequence databases
EMBLGenBankDDBJ	L25350 mRNA. Translation: AAA46855.1. Z26523 Genomic RNA. Translation: CAA81294.1.
PIR	S37253.
3D structure databases
SMR	Q89770. Positions 142-572.
ModBase	Search...
Family and domain databases
InterPro	IPR000665. Hemagglutn-neuramid_glycoprot. IPR016285. Hemagglutn-neuramid_paramyxo. [Graphical view]
Pfam	PF00423. HN. 1 hit. [Graphical view]
PIRSF	PIRSF001072. Hemagglut-neuramid_paramyxoV. 1 hit.

Entry information

Entry name

Q89770_9PARA

Accession

Primary (citable) accession number: Q89770

Entry history

Integrated into UniProtKB/TrEMBL:	November 1, 1996
Last sequence update:	November 1, 1996
Last modified:	July 22, 2008
This is version 44 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)