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Reviewed, UniProtKB/Swiss-Prot Q8AWY2 (HXAAB_DANRE)

Last modified July 22, 2008. Version 34. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Homeobox protein Hox-A10b
      Short name=Hox-A10
Gene names
Name: hoxa10b
Synonyms: hoxa10
OrganismDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifier7955 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Cyprinidae › Danio

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Protein attributes

Sequence length330 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at transcript level.

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General annotation (Comments)

Function

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis By similarity.

Subcellular location

NucleusBy similarity.

Developmental stage

At the 10-somite stage, expressed in the paraxial mesoderm with an anterior expression limit posterior to the last somite. At the 20-somite stage, expressed within the developing CNS with an anterior expression limit adjacent to the somite 10/11 boundary.

Sequence similarities

Belongs to the Abd-B homeobox family.

Contains 1 homeobox DNA-binding domain.

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Ontologies

Keywords

   Biological processTranscription
Transcription regulation
   Cellular componentNucleus
   DomainHomeobox
   LigandDNA-binding
   Molecular functionDevelopmental protein

Gene Ontology (GO)

None. [Check GOA]

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical view

Molecule processing

Chain1 – 330330Homeobox protein Hox-A10b

Regions

DNA binding256 – 31560Homeobox

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Sequences

Sequence LengthMass (Da)Tools
Q8AWY2-1 [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: 0236BAE98AAC37AC

FASTA33036,947
        10         20         30         40         50         60 
MSCSDSPSGN SFLVDSLIHG RSEGSGHYYQ NSGVYLQPTS EYSYGLSNCG YFSGLKRNES 

        70         80         90        100        110        120 
NSQNVVPTCG PYQGMETWLE TSRSCRIEQP NSQITPRSFS PTIKEENSYC LYESEKCPKE 

       130        140        150        160        170        180 
TITEDISYSR LTPNSCPSSN NNGCVPVPGY FRLSQTCTTS KGFTDNQTIP THVVAQRSTR 

       190        200        210        220        230        240 
FDSSLSAIAA EASRDESDEP PTCAPCAPGR NKELRGSTGT ASSPEPPDSP EKAVTVTKAG 

       250        260        270        280        290        300 
DSKSESTANW LTAKSGRKKR CPYTKHQTLE LEKEFLFNMY LTRERRLEIS RSVHLTDRQV 

       310        320        330 
KIWFQNRRMK LKKMSRENRI RELSANFSFS

« Hide

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References

« Hide 'large scale' references
[1]The Danio rerio sequencing project at the Sanger Institute
Submitted (DEC-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: AB.
[2]"Genomic annotation and transcriptome analysis of the zebrafish (Danio rerio) hox complex with description of a novel member, hoxb13a."
Corredor-Adamez M., Welten M.C.M., Spaink H.P., Jeffery J.E., Schoon R.T., de Bakker M.A.G., Bagowski C.P., Meijer A.H., Verbeek F.J., Richardson M.K.
Evol. Dev. 7:362-375(2005) [PubMed: 16174031] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 154-242.
Strain: Tuebingen.
[3]"Zebrafish hox genes: genomic organization and modified colinear expression patterns in the trunk."
Prince V.E., Joly L., Ekker M., Ho R.K.
Development 125:407-420(1998) [PubMed: 9425136] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 287-330, DEVELOPMENTAL STAGE.
Tissue: Embryo.

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Cross-references

Sequence databases

AL645795 Genomic DNA. Translation: CAD59110.1.
DQ060538 mRNA. Translation: AAY67916.1.
Y14527 mRNA. Translation: CAA74862.1.
RefSeqNP_571230.1.
UniGeneDr.75784

3D structure databases

HSSPHSSP built from PDB template 1PUF based on UniProtKB P09631.
SMRQ8AWY2. Positions 248-317.
ModBaseSearch...

Genome annotation databases

EnsemblENSDARG00000031337. Danio rerio. [Contig view]
GeneID30391.
KEGGdre:30391.

Organism-specific databases

ZFINZDB-GENE-990415-97. hoxa10b.

Phylogenomic databases

HOGENOMQ8AWY2.
HOVERGENQ8AWY2.

Gene expression databases

ArrayExpressQ8AWY2.

Family and domain databases

InterProIPR001356. Homeobox.
IPR012287. Homeodomain-rel.
[Graphical view]
Gene3DG3DSA:1.10.10.60. Homeodomain-rel. 1 hit.
PfamPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSPR00024. HOMEOBOX.
ProDomPD000010. Homeobox. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTSM00389. HOX. 1 hit.
[Graphical view]
PROSITEPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
BLOCKSSearch...

Other Resources

ProtoNetSearch...

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Entry information

Entry nameHXAAB_DANRE
AccessionPrimary (citable) accession number: Q8AWY2
Secondary accession number(s): O57357, Q4PRA5
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: March 1, 2003
Last modified: July 22, 2008
This is version 34 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectZebrafish annotation project

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Relevant documents

Vertebrate homeotic Hox proteins

Nomenclature of vertebrate homeotic Hox proteins and list of entries

UniProtKB secondary accession numbers

Index of UniProtKB secondary accession numbers

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents