Reviewed, UniProtKB/Swiss-Prot Q8BM55 (TM214_MOUSE)

Names and origin

Protein names

Recommended name:
    Transmembrane protein 214

Gene names

Name:

Tmem214

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

Protein attributes

Sequence length	687 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Subcellular location	Membrane; Multi-pass membrane proteinPotential.
Sequence similarities	Belongs to the TMEM214 family.

Ontologies

Keywords
Cellular component	Membrane
Coding sequence diversity	Alternative splicing
Domain	Transmembrane
PTM	Glycoprotein
Gene Ontology (GO)
None. [Check GOA]

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q8BM55-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q8BM55-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-303: Missing.

Isoform 3 (identifier: Q8BM55-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-313: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view
Molecule processing
	Chain	1 – 687	687	Transmembrane protein 214
Regions
	Transmembrane	481 – 501	21	Potential
	Transmembrane	614 – 634	21	Potential
Amino acid modifications
	Glycosylation	269	1	N-linked (GlcNAc...) Potential
	Glycosylation	307	1	N-linked (GlcNAc...) Potential
Natural variations
	Alternative sequence	1 – 313	313	Missing in isoform 3.
	Alternative sequence	1 – 303	303	Missing in isoform 2.
Experimental info
	Sequence conflict	33	1	S → G in BAE38819. Ref.1
	Sequence conflict	180	1	G → R in BAE25265. Ref.1
	Sequence conflict	376	1	S → N in BAE38819. Ref.1
	Sequence conflict	395	1	V → I in BAE38819. Ref.1
	Sequence conflict	456	1	G → S in BAE38819. Ref.1
	Sequence conflict	658	1	L → F in BAE38819. Ref.1
	Sequence conflict	670	1	Q → H in BAE25265. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified March 1, 2003. Version 1. Checksum: E72AA7DF5486E968	FASTA	687	76,430
	10 20 30 40 50 60 MAARSAGSGG WEVVKRGRRP GASSGGRGGG GGSDRRALGE ANGVLKYDLS SPIQTTSTLY 70 80 90 100 110 120 ERGFEKIMKR QNKEQVPPPA AESKKPINKK QPKKVTAVPS QNQKQGPFRR LEDALKALDV 130 140 150 160 170 180 AALQKELDKS QSVFTGNPSV WLKDLASYLN YKLQTPRMEP TLSQYPHDYP YSLVSRELRG 190 200 210 220 230 240 IIRGLLTKAA GSVELFFDHC LFTMLQELDK TPGESLHGYR ICIQAVLQDK PKIVTSNLDK 250 260 270 280 290 300 FLELLRSHQS RPAKCLTIMW ALGQAGFTNL TEGLKVWLGI MLPVLGIKAL SPFAIAYLDR 310 320 330 340 350 360 LLLMHPNLTK GFGMIGPKDF FPLLDFAYMP NNSLSPSLQE QLCQLFPRLK VLAFGAKPES 370 380 390 400 410 420 SLHTYFPSFL SRATPSCPAA MKKELLASLT QCLTVDPLST SVWRQLYPKH LSQSSLLLEH 430 440 450 460 470 480 LLKSWEHIPK KARKSLQETI QSLKVTNQEL LKKGSGGSEH VLTCDTACKG LLQRARGPRP 490 500 510 520 530 540 PWARLFLLLL VFAVGFLCHD LRSNSSLQAS LTGRLLRSSG LLPVGQQVCA RLSSYSLQSY 550 560 570 580 590 600 NWLQETLPAC GSHLLAVVQP SLQLAWTHIY AIFSFLSAHC ASYLACFSDS LAGFFQRVQL 610 620 630 640 650 660 PEALQQLFHA LKELLLLFCH SVLLPTWHLL LAALAQVQEH CHEACRGDVT WDCIKTQLSR 670 680 AAQWTWLCLQ DVTVAFLDWA LTMISQQ
	Isoform 2 [UniParc]. Checksum: 2257981106FFEAA6		384	42,984
	10 20 30 40 50 60 MHPNLTKGFG MIGPKDFFPL LDFAYMPNNS LSPSLQEQLC QLFPRLKVLA FGAKPESSLH 70 80 90 100 110 120 TYFPSFLSRA TPSCPAAMKK ELLASLTQCL TVDPLSTSVW RQLYPKHLSQ SSLLLEHLLK 130 140 150 160 170 180 SWEHIPKKAR KSLQETIQSL KVTNQELLKK GSGGSEHVLT CDTACKGLLQ RARGPRPPWA 190 200 210 220 230 240 RLFLLLLVFA VGFLCHDLRS NSSLQASLTG RLLRSSGLLP VGQQVCARLS SYSLQSYNWL 250 260 270 280 290 300 QETLPACGSH LLAVVQPSLQ LAWTHIYAIF SFLSAHCASY LACFSDSLAG FFQRVQLPEA 310 320 330 340 350 360 LQQLFHALKE LLLLFCHSVL LPTWHLLLAA LAQVQEHCHE ACRGDVTWDC IKTQLSRAAQ 370 380 WTWLCLQDVT VAFLDWALTM ISQQ
	Isoform 3 [UniParc]. Checksum: 12FA2EA12715A7C7		374	41,901
	10 20 30 40 50 60 MIGPKDFFPL LDFAYMPNNS LSPSLQEQLC QLFPRLKVLA FGAKPESSLH TYFPSFLSRA 70 80 90 100 110 120 TPSCPAAMKK ELLASLTQCL TVDPLSTSVW RQLYPKHLSQ SSLLLEHLLK SWEHIPKKAR 130 140 150 160 170 180 KSLQETIQSL KVTNQELLKK GSGGSEHVLT CDTACKGLLQ RARGPRPPWA RLFLLLLVFA 190 200 210 220 230 240 VGFLCHDLRS NSSLQASLTG RLLRSSGLLP VGQQVCARLS SYSLQSYNWL QETLPACGSH 250 260 270 280 290 300 LLAVVQPSLQ LAWTHIYAIF SFLSAHCASY LACFSDSLAG FFQRVQLPEA LQQLFHALKE 310 320 330 340 350 360 LLLLFCHSVL LPTWHLLLAA LAQVQEHCHE ACRGDVTWDC IKTQLSRAAQ WTWLCLQDVT 370 VAFLDWALTM ISQQ

References

[1]

"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Strain: C57BL/6J. Tissue: Embryo and Eye.

[2]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3). Strain: FVB/N. Tissue: Colon, Eye, Liver and Mammary tumor.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AK143078 mRNA. Translation: BAE25265.1. AK166510 mRNA. Translation: BAE38819.1. AK034883 mRNA. Translation: BAC28866.1. BC022602 mRNA. Translation: AAH22602.1. BC022142 mRNA. Translation: AAH22142.1. Different initiation. BC026651 mRNA. Translation: AAH26651.1. Different initiation. BC027046 mRNA. Translation: AAH27046.1. BC029150 mRNA. Translation: AAH29150.3.
RefSeq	NP_653108.2.
UniGene	Mm.205169
3D structure databases
ModBase	Search...
Genome annotation databases
Ensembl	ENSMUSG00000038828. Mus musculus. [Contig view]
GeneID	68796.
KEGG	mmu:68796.
Organism-specific databases
MGI	MGI:1916046. 1110039B18Rik.
Phylogenomic databases
HOVERGEN	Q8BM55.
Gene expression databases
ArrayExpress	Q8BM55.
CleanEx	MM_1110039B18RIK.
Family and domain databases
ProDom	Q8BM55. [Graphical view] [Entries sharing at least one domain]
BLOCKS	Search...
Other Resources
SOURCE	Search...
ProtoNet	Search...

Entry information

Entry name

TM214_MOUSE

Accession

Primary (citable) accession number: Q8BM55
Secondary accession number(s): Q3TLH3 , Q3UPX9, Q78HK3, Q8R0D5, Q8R237, Q8VC05

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 26, 2008
Last sequence update:	March 1, 2003
Last modified:	July 22, 2008
This is version 57 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)