Reviewed, UniProtKB/Swiss-Prot Q8BWR2 (CA128_MOUSE)

Names and origin

Protein names

Recommended name:
    UPF0424 protein C1orf128 homolog

Gene names

Name:

Trp26

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

Protein attributes

Sequence length	211 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Sequence similarities

Belongs to the UPF0424 family.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing
PTM	Phosphoprotein
Gene Ontology (GO)
None. [Check GOA]

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q8BWR2-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q8BWR2-2)

The sequence of this isoform differs from the canonical sequence as follows:
     193-211: ANPADHRVHQVTPQTHFIS → PNQQTTGCIRSLRRHTSFLKGQPGLPQMRC

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view
Molecule processing
	Chain	1 – 211	211	UPF0424 protein C1orf128 homolog
Regions
	Compositional bias	8 – 11	4	Poly-Gly
Amino acid modifications
	Modified residue	189	1	Phosphotyrosine By similarity
Natural variations
	Alternative sequence	193 – 211	19	ANPAD…THFIS → PNQQTTGCIRSLRRHTSFLK GQPGLPQMRC in isoform 2.

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified March 1, 2003. Version 1. Checksum: 159409B77F6F3C3D	FASTA	211	24,192
	10 20 30 40 50 60 MSHGHSHGGG GCRCAAEREE PPEQRGLAYG LYLRIDLERL QCLNESREGS GRGVFKPWEE 70 80 90 100 110 120 RTDRSKFVES DADEELLFNI PFTGNVKLKG VIIMGEDDDS HPSEMRLYKN IPQMSFDDTE 130 140 150 160 170 180 REPEQTFSLN RDITGELEYA TKISRFSNVY HLSIHISKNF GADTTKIFYI GLRGEWTELR 190 200 210 RHEVTICNYE ASANPADHRV HQVTPQTHFI S
	Isoform 2 [UniParc]. Checksum: 263DC236E995B223		222	25,448
	10 20 30 40 50 60 MSHGHSHGGG GCRCAAEREE PPEQRGLAYG LYLRIDLERL QCLNESREGS GRGVFKPWEE 70 80 90 100 110 120 RTDRSKFVES DADEELLFNI PFTGNVKLKG VIIMGEDDDS HPSEMRLYKN IPQMSFDDTE 130 140 150 160 170 180 REPEQTFSLN RDITGELEYA TKISRFSNVY HLSIHISKNF GADTTKIFYI GLRGEWTELR 190 200 210 220 RHEVTICNYE ASPNQQTTGC IRSLRRHTSF LKGQPGLPQM RC

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular cloning of TRP26, a novel member of the thioredoxin family, which is related to TRP32." Kondo N., Yodoi J., Tagaya Y. Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[2]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2). Strain: C57BL/6J. Tissue: Liver.
[3]	The mouse genome sequencing consortium Submitted (JAN-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C57BL/6J.
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Strain: C57BL/6.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF400670 mRNA. Translation: AAO85407.1. AK004208 mRNA. Translation: BAC25071.1. AK050261 mRNA. Translation: BAC34151.1. AL672076 Genomic DNA. Translation: CAM15906.1. BC052695 mRNA. Translation: AAH52695.1.
RefSeq	NP_079687.3.
UniGene	Mm.29131
3D structure databases
ModBase	Search...
PTM databases
PhosphoSite	Q8BWR2.
Genome annotation databases
Ensembl	ENSMUSG00000028669. Mus musculus. [Contig view]
GeneID	66193.
KEGG	mmu:66193.
Organism-specific databases
MGI	MGI:1913443. 1110049F12Rik.
Phylogenomic databases
HOVERGEN	Q8BWR2.
Gene expression databases
ArrayExpress	Q8BWR2.
CleanEx	MM_1110049F12RIK.
Family and domain databases
InterPro	IPR010400. DUF1000. [Graphical view]
Pfam	PF06201. DUF1000. 1 hit. [Graphical view]
ProDom	Q8BWR2. [Graphical view] [Entries sharing at least one domain]
BLOCKS	Search...
Other Resources
SOURCE	Search...
ProtoNet	Search...

Entry information

Entry name

CA128_MOUSE

Accession

Primary (citable) accession number: Q8BWR2
Secondary accession number(s): Q8BMZ1

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 1, 2007
Last sequence update:	March 1, 2003
Last modified:	July 22, 2008
This is version 38 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)