Reviewed, UniProtKB/Swiss-Prot Q8C5H8 (CE033_MOUSE)

Names and origin

Protein names	Recommended name:     UPF0465 protein C5orf33 homolog
Organism	Mus musculus (Mouse)
Taxonomic identifier	10090 [NCBI]
Taxonomic lineage	Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

Protein attributes

Sequence length	452 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Sequence similarities	Belongs to the UPF0465 family.
Sequence caution	The sequence BAB23041.1 differs from that shown. Reason: Frameshift at position 80.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing
PTM	Phosphoprotein
Gene Ontology (GO)
Cellular component	mitochondrion Inferred from direct assay. Source: MGI
Complete GO annotation...

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q8C5H8-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q8C5H8-2)

The sequence of this isoform differs from the canonical sequence as follows:
     276-297: Missing.
     408-452: Missing.

Isoform 3 (identifier: Q8C5H8-3)

The sequence of this isoform differs from the canonical sequence as follows:
     276-297: Missing.

Isoform 4 (identifier: Q8C5H8-4)

The sequence of this isoform differs from the canonical sequence as follows:
     175-202: Missing.
     276-297: Missing.

Notes: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view
Molecule processing
	Chain	1 – 452	452	UPF0465 protein C5orf33 homolog
Amino acid modifications
	Modified residue	176	1	Phosphoserine
Natural variations
	Alternative sequence	175 – 202	28	Missing in isoform 4.
	Alternative sequence	276 – 297	22	Missing in isoform 2, isoform 3 and isoform 4.
	Alternative sequence	408 – 452	45	Missing in isoform 2.
Experimental info
	Sequence conflict	62	1	V → G in BAB23041. Ref.1
	Sequence conflict	81	1	S → P in BAB23041. Ref.1
	Sequence conflict	207	1	R → S in BAB23041. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified July 24, 2007. Version 2. Checksum: C0FC67A5BA762D1B	FASTA	452	50,859
	10 20 30 40 50 60 MTCYRGFLLG SCRRVAGGRA ALRGSGSGAD GRRHLGHGQP RELAGGGSPA DGGFRPSRVV 70 80 90 100 110 120 VVAKTTRYEF EQQRYRYAEL SEEDLKQLLA LKGSSYSGLL ERHHIHTKNV EHIIDSLRDE 130 140 150 160 170 180 GIEVRLVKRR EYDEETVRWA DAVIAAGGDG TMLLAASKVL DRLKPVIGVN TDPERSEGHL 190 200 210 220 230 240 CLPVRYTHSF PEALRRFSRG EFRWLWRQRI RLYLEGTGIN PTPVDLHEQQ LSLNQHSRAF 250 260 270 280 290 300 NIERAHDERS EASGPQLLPV RALNEVFIGE SLSSRMPYCW AVAVDNLRRD IPNLKGLASY 310 320 330 340 350 360 YEISVDDGPW EKQKSSGLNL CTGTGSKAWS FNINRVAAQA VEDVLHIARR QGNLTLPLNK 370 380 390 400 410 420 DLVEKVTNEY NESLLYSPEE PKILFSIREP IANRVFSSSR QRCFSSKVCV RSRCWDACMV 430 440 450 VDGGTSFEFN DGAIASMMIN KEDELRTVIL EQ
	Isoform 2 [UniParc]. Checksum: A7E10B3ABE5699D4		385	43,309
	10 20 30 40 50 60 MTCYRGFLLG SCRRVAGGRA ALRGSGSGAD GRRHLGHGQP RELAGGGSPA DGGFRPSRVV 70 80 90 100 110 120 VVAKTTRYEF EQQRYRYAEL SEEDLKQLLA LKGSSYSGLL ERHHIHTKNV EHIIDSLRDE 130 140 150 160 170 180 GIEVRLVKRR EYDEETVRWA DAVIAAGGDG TMLLAASKVL DRLKPVIGVN TDPERSEGHL 190 200 210 220 230 240 CLPVRYTHSF PEALRRFSRG EFRWLWRQRI RLYLEGTGIN PTPVDLHEQQ LSLNQHSRAF 250 260 270 280 290 300 NIERAHDERS EASGPQLLPV RALNEVFIGE SLSSRASYYE ISVDDGPWEK QKSSGLNLCT 310 320 330 340 350 360 GTGSKAWSFN INRVAAQAVE DVLHIARRQG NLTLPLNKDL VEKVTNEYNE SLLYSPEEPK 370 380 ILFSIREPIA NRVFSSSRQR CFSSK
	Isoform 3 [UniParc]. Checksum: 0B92E5E4D3234688		430	48,332
	10 20 30 40 50 60 MTCYRGFLLG SCRRVAGGRA ALRGSGSGAD GRRHLGHGQP RELAGGGSPA DGGFRPSRVV 70 80 90 100 110 120 VVAKTTRYEF EQQRYRYAEL SEEDLKQLLA LKGSSYSGLL ERHHIHTKNV EHIIDSLRDE 130 140 150 160 170 180 GIEVRLVKRR EYDEETVRWA DAVIAAGGDG TMLLAASKVL DRLKPVIGVN TDPERSEGHL 190 200 210 220 230 240 CLPVRYTHSF PEALRRFSRG EFRWLWRQRI RLYLEGTGIN PTPVDLHEQQ LSLNQHSRAF 250 260 270 280 290 300 NIERAHDERS EASGPQLLPV RALNEVFIGE SLSSRASYYE ISVDDGPWEK QKSSGLNLCT 310 320 330 340 350 360 GTGSKAWSFN INRVAAQAVE DVLHIARRQG NLTLPLNKDL VEKVTNEYNE SLLYSPEEPK 370 380 390 400 410 420 ILFSIREPIA NRVFSSSRQR CFSSKVCVRS RCWDACMVVD GGTSFEFNDG AIASMMINKE 430 DELRTVILEQ
	Isoform 4 [UniParc]. Checksum: E6B139A5248DEF09		402	45,001
	10 20 30 40 50 60 MTCYRGFLLG SCRRVAGGRA ALRGSGSGAD GRRHLGHGQP RELAGGGSPA DGGFRPSRVV 70 80 90 100 110 120 VVAKTTRYEF EQQRYRYAEL SEEDLKQLLA LKGSSYSGLL ERHHIHTKNV EHIIDSLRDE 130 140 150 160 170 180 GIEVRLVKRR EYDEETVRWA DAVIAAGGDG TMLLAASKVL DRLKPVIGVN TDPERWLWRQ 190 200 210 220 230 240 RIRLYLEGTG INPTPVDLHE QQLSLNQHSR AFNIERAHDE RSEASGPQLL PVRALNEVFI 250 260 270 280 290 300 GESLSSRASY YEISVDDGPW EKQKSSGLNL CTGTGSKAWS FNINRVAAQA VEDVLHIARR 310 320 330 340 350 360 QGNLTLPLNK DLVEKVTNEY NESLLYSPEE PKILFSIREP IANRVFSSSR QRCFSSKVCV 370 380 390 400 RSRCWDACMV VDGGTSFEFN DGAIASMMIN KEDELRTVIL EQ

References

[1]

"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 63-452 (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 63-452 (ISOFORM 3), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 61-452 (ISOFORM 4). Strain: C57BL/6J. Tissue: Adipose tissue, Cerebellum, Embryo, Olfactory bulb and Retina.

[2]

"Large-scale phosphorylation analysis of mouse liver." Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007) [PubMed: 17242355] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-176, MASS SPECTROMETRY. Tissue: Liver.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AK003858 mRNA. Translation: BAB23041.1. Frameshift. AK046666 mRNA. No translation available. AK078318 mRNA. Translation: BAC37218.1. AK149267 mRNA. Translation: BAE28780.1. Different initiation. AK162601 mRNA. Translation: BAE36982.1.
RefSeq	NP_001078879.1.
UniGene	Mm.244226 Mm.468219
3D structure databases
ModBase	Search...
PTM databases
PhosphoSite	Q8C5H8.
2-D gel databases
REPRODUCTION-2DPAGE	Q8C5H8. Q9CTE4.
Genome annotation databases
Ensembl	ENSMUSG00000022253. Mus musculus. [Contig view]
GeneID	68646.
NMPDR	fig|10090.3.peg.29672.
Organism-specific databases
MGI	MGI:1915896. 1110020G09Rik.
Phylogenomic databases
HOGENOM	Q8C5H8.
HOVERGEN	Q8C5H8.
Gene expression databases
ArrayExpress	Q8C5H8.
CleanEx	MM_1110020G09RIK.
Family and domain databases
InterPro	IPR012355. ATP-NAD_like_euk. IPR002504. ATP_NADK. [Graphical view]
Pfam	PF01513. NAD_kinase. 1 hit. [Graphical view]
PIRSF	PIRSF017565. Kin_ATP-NAD_euk. 1 hit.
ProDom	Q8C5H8. [Graphical view] [Entries sharing at least one domain]
BLOCKS	Search...
Other Resources
ProtoNet	Search...

Entry information

Entry name

CE033_MOUSE

Accession

Primary (citable) accession number: Q8C5H8
Secondary accession number(s): Q3TRP5, Q3UEY1, Q9CTE4

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 24, 2007
Last sequence update:	July 24, 2007
Last modified:	July 22, 2008
This is version 35 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)