Reviewed, UniProtKB/Swiss-Prot Q8IVF2 (AHNK2_HUMAN)

Names and origin

Protein names

Recommended name:
    Protein AHNAK2

Gene names

Name:	AHNAK2
Synonyms:	C14orf78, KIAA2019

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	5795 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Subcellular location	NucleusBy similarity.
Sequence similarities	Contains 1 PDZ (DHR) domain.
Sequence caution	BAC23115.1 sequence differs from that shown. Reason: Frameshift at position 3008.

Ontologies

Keywords
Cellular component	Nucleus
Coding sequence diversity	Alternative splicing Polymorphism
Gene Ontology (GO)
None. [Check GOA]

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q8IVF2-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q8IVF2-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-5002: Missing.

Notes: No experimental confirmation available.

Isoform 3 (identifier: Q8IVF2-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-100: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view
Molecule processing
	Chain	1 – 5795	5795	Protein AHNAK2
Regions
	Domain	112 – 193	82	PDZ
Natural variations
	Alternative sequence	1 – 5002	5002	Missing in isoform 2.
	Alternative sequence	1 – 100	100	Missing in isoform 3.
	Natural variant	1266	1	V → M: dbSNP rs11850930.
	Natural variant	1470	1	L → V: dbSNP rs12890949.
	Natural variant	2115	1	S → R: dbSNP rs2582514.
	Natural variant	2429	1	D → E: dbSNP rs11160826.
	Natural variant	2430	1	L → V: dbSNP rs2819426.
	Natural variant	2616	1	V → A: dbSNP rs4264326.
	Natural variant	5028	1	L → M: dbSNP rs9672139.
	Natural variant	5564	1	G → R: dbSNP rs2819420.
Experimental info
	Sequence conflict	3195	1	P → L in BAC23115. Ref.4
	Sequence conflict	3198	1	A → V in BAC23115. Ref.4
	Sequence conflict	4664	1	T → A in CAD98019. Ref.5
	Sequence conflict	4740	1	E → G in CAD98019. Ref.5
	Sequence conflict	5139	1	G → E in CAD97904, CAD97981 and CAD98019. Ref.5
	Sequence conflict	5184	1	Y → D in CAD97904, CAD97981 and CAD98019. Ref.5
	Sequence conflict	5269	1	L → P in CAD98019. Ref.5
	Sequence conflict	5397	1	P → A in AAH11859 and AAH49216. Ref.2
	Sequence conflict	5397	1	P → A in CAD97904, CAD97981 and CAD98019. Ref.5
	Sequence conflict	5560	1	D → G in CAD97904. Ref.5
	Sequence conflict	5577	1	I → V in CAD97904. Ref.5
	Sequence conflict	5590	1	T → A in CAD97981. Ref.5
	Sequence conflict	5601	1	D → G in CAD98034. Ref.5

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified February 26, 2008. Version 2. Checksum: BEC73677308C1FAB	FASTA	5,795	616,629
	10 20 30 40 50 60 MCDCFHMVLP TWPGTPGSVS GRQLQPGEPG AETEDDHSVT EGPADEGIRP RPQGSSPVYE 70 80 90 100 110 120 YTTEAADFGL QEDAPGRQGS AGRRRSWWKR DSGDSRTFFR MSRPEAVQEA TEVTLKTEVE 130 140 150 160 170 180 AGASGYSVTG GGDQGIFVKQ VLKDSSAAKL FNLREGDQLL STTVFFENIK YEDALKILQY 190 200 210 220 230 240 SEPYKVQFKI RRQLPAPQDE EWASSDAQHG PQGKEKEDTD VADGCRETPT KTLEGDGDQE 250 260 270 280 290 300 RLISKPRVGR GRQSQRERLS WPKFQSIKSK RGPGPQRSHS SSEAYEPRDA HDVSPTSTDT 310 320 330 340 350 360 EAQLTVERQE QKAGPGSQRR RKFLNLRFRT GSGQGPSSTG QPGRGFQSGV GRAGVLEELG 370 380 390 400 410 420 PWGDSLEETG AATGSRREER AEQDREVMPA QSMPLPTELG DPRLCEGTPQ EGGLRAARLH 430 440 450 460 470 480 GKTLEGQAQE TAVAQRKPRA QPTPGMSREG EGEGLQSLEI GIARLSLRDT TEGGTQIGPP 490 500 510 520 530 540 EIRVRVHDLK TPKFAFSTEK EPERERRLST PQRGKRQDAS SKAGTGLKGE EVEGAGWMPG 550 560 570 580 590 600 REPTTHAEAQ GDEGDGEEGL QRTRITEEQD KGREDTEGQI RMPKFKIPSL GWSPSKHTKT 610 620 630 640 650 660 GREKATEDTE QGREGEATAT ADRREQRRTE EGLKDKEDSD SMTNTTKIQL IHDEKRLKKE 670 680 690 700 710 720 QILTEKEVAT KDSKFKMPKF KMPLFGASAP GKSMEASVDV SAPKVEADVS LLSMQGDLKT 730 740 750 760 770 780 TDLSVQTPSA DLEVQDGQVD VKLPEGPLPE GASLKGHLPK VQRPSLKMPK VDLKGPKLDL 790 800 810 820 830 840 KGPKAEVTAP DVKMSLSSME VDVQAPRAKL DGARLEGDLS LADKEVTAKD SKFKMPKFKM 850 860 870 880 890 900 PSFGVSAPGK SMEDSVDVSA PKVEADVSLS SMQGDLKATD LSIQPPSADL EVQAGQVDVK 910 920 930 940 950 960 LPEGPVPEGA GPKVHLPKVE MPSFKMPKVD LKGPQIDVKG PKLDLKGPKA EVTAPDGEVS 970 980 990 1000 1010 1020 LPSMEVDVQA QKAKLDGAWL EGDLSLADKD VTAKDSKFKM PKFKMPSFGV SAPGKSIKAL 1030 1040 1050 1060 1070 1080 VDVSAPKVEA DLSLPSMQGD LKTTDLSIQP ASTDLKVQAD QVDVKLPEGH LPEGAGLKGH 1090 1100 1110 1120 1130 1140 LPKVEMPSFK MPKVALKGPQ VDVKGPKLDL KSPKAEVTAP DVEVSLPSVE VDVEAPGAKL 1150 1160 1170 1180 1190 1200 DSARLEGELS LADKDVTAKD SRFKMPKFKM PSFGASAPGK SIEASVDVSA PKVEADVSLP 1210 1220 1230 1240 1250 1260 SMQGDLKTTD LSIQPPSADL EVHAGQVDVK LLEGHVPEGA GFKGHLPKVQ MPSLKMPKVD 1270 1280 1290 1300 1310 1320 LKGPQVEVRG PKLDLKGHKA EVTAHEVAVS LPSVEVDMQA PGAKLDGAQL DGDLSLADKD 1330 1340 1350 1360 1370 1380 VTAKDSKFKM PKFKMPSFGV SAPGKSIEAS VDLSAPKVEA DMSLPSMQGD LKTTDLSIQP 1390 1400 1410 1420 1430 1440 PSTDLELQAG QLDVKLPEGP VPEGAGLKGH LPKLQMPSFK VPKVDLKGPE IDIKGPKLDL 1450 1460 1470 1480 1490 1500 KDPKVEVTAP DVEVSLPSVE VDVEAPGAKL DGGRLEEDMS LADKDLTTKD SKFKMPKFKM 1510 1520 1530 1540 1550 1560 PSFGVSAPGK SIEASVDVSA PKVEADVSLP SMQGDLKATD LSIQPPSADL EVQAGQVDVK 1570 1580 1590 1600 1610 1620 LPEGPVSEGA GLKGHLPKVQ MPSFKMPKVD LKGPQIDVKG PKLDLKGPKV EVTAPDVKMS 1630 1640 1650 1660 1670 1680 LSSMEVDVQA PRAKLDGAQL EGDLSLADKA VTAKDSKFKM PKFKMPSFGV SAPGKSIEAS 1690 1700 1710 1720 1730 1740 VDVSEPKVEA DVSLPSMQGD LKTTDLSIQS PSADLEVQAG QVNVKLPEGP LPEGAGFKGH 1750 1760 1770 1780 1790 1800 LPKVQMPSLK MPKVALKGPQ MDVKGPKLDL KGPKAEVMAP DVEVSLPSVE VDVEAPGAKL 1810 1820 1830 1840 1850 1860 DSVRLEGDLS LADKDVTAKD SKFKMPKFKM PSFGVSAPGK SIEASVDVSA PKVEAEVSLP 1870 1880 1890 1900 1910 1920 SMQGDLKTTD LCIPLPSADL VVQAGQVDMK LPEGQVPEGA GLKGHLPKVD MPSFKMPKVD 1930 1940 1950 1960 1970 1980 LKGPQTDVKG AKLDLKGPKA EVTAPDVEVS LPSMEVDVQA QKAKLDGARL EGDLSLADKD 1990 2000 2010 2020 2030 2040 MTAKDSKFKM PKFKMPSFGV SAPGRSIEAS VDVPAPKVEA DVSLPSMQGD LKTTDLSIQP 2050 2060 2070 2080 2090 2100 PSADLKVQTG QVDVKLPEGH VPEGAGLKGH LPKVEMPSLK MPKVDLKGPQ VDIKGPKLDL 2110 2120 2130 2140 2150 2160 KDPKVEMRVP DVEVSLPSME VDVQAPRAKL DSAHLQGDLT LANKDLTTKD SKFKMPKFKM 2170 2180 2190 2200 2210 2220 PSFGVSAPGK SIEASVDVSP PKVEADMSLP SMQGDLKTTD LSIQPLSADV KVQAGQVDVK 2230 2240 2250 2260 2270 2280 LLEGPVPEEV GLKGHLPKLQ MPSFKVPKVD LKGPEIDIKG PKLDLKDPKV EVTAPDVEVS 2290 2300 2310 2320 2330 2340 LPSVEVDVKA PGAKLDGARL EGDMSLADKD VTAKDSKFKM PKFKMLSFGV SALGKSIEAS 2350 2360 2370 2380 2390 2400 ADVSALKVEA DVSLPSMQGD LKTTDLSVQP PSADLEVQAG QVDVKLPEGP VPEGAGLKGH 2410 2420 2430 2440 2450 2460 LPKLQMPSFK MPKVDLKGPQ IDVKGPKLDL KGPKTDVMAP DVEVSQPSVE VDVEAPGAKL 2470 2480 2490 2500 2510 2520 DGAWLEGDLS VADKDVTTKD SRFKIPKFKM PSFGVSAPGK SIEASVDVSA PKVEADGSLS 2530 2540 2550 2560 2570 2580 SMQGDLKATD LSIQPPSADL EVQAGQVDVK LPEGPVPEGA GLKGHLPKVQ MPSFKMPEMD 2590 2600 2610 2620 2630 2640 LKGPQLDVKG PKLDLKGPKA EVTAPDVEMS LSSMEVDVQA PRAKLDGARL EGDLSLADKG 2650 2660 2670 2680 2690 2700 VTAKDSKFKM PKFKMPSFRV SAPGESIEAL VDVSELKVEA DMSLPSMQGD LKTTDISIQP 2710 2720 2730 2740 2750 2760 PSAQLEVQAG QVDVKLPEGH VPEGAGLKGH LPKLQMPSFK MPEVDLKGPQ IDVKGPNVDL 2770 2780 2790 2800 2810 2820 KGPKAEVTAP DVKMSLSSME VDVQAPRAKL DGARLEGDLS LADKGMTAKD SKFKMPKFKM 2830 2840 2850 2860 2870 2880 PSFGVSAPGK SIEASVDVSE LKVEADGSFP SMQGDLKTTD IRIQPPSAQL EVQAGQVDVK 2890 2900 2910 2920 2930 2940 LPEGHVPEGA GLKGHLPKVQ MPSFKMPKVD LKGPQIDVKG PKLDLKGPKA EVTAPDVEVS 2950 2960 2970 2980 2990 3000 LPSVEVDVEA PRAKLDGARL EGDLSLADKD VTAKDSKFKM PKFKMPSFGV SAPGKSIEVS 3010 3020 3030 3040 3050 3060 VDVSAPKVEA EVSLPSMQGD LKTTDISIEP PSAQLEVQAG QVDLKLPEGH VPEGAGLKGH 3070 3080 3090 3100 3110 3120 LPKLQMPSFK MPKVDRKGPQ IDVKGPKLDL KGPKTDVTAP DVEVSQPGME VDVEAPGAKL 3130 3140 3150 3160 3170 3180 DGARLEGDLS LADKDVTAKD SKFKMPKFKM PSFGVSAPGK SIEVLVDVSA PKVEADLSLP 3190 3200 3210 3220 3230 3240 SMQGDLKNTD ISIEPPSAQL EVQAGQVDVK LPEGHVLEGA GLKGHLPKLQ MPSFKMPKVD 3250 3260 3270 3280 3290 3300 RKGPQIDIKG PKLDLKGPKM DVTAPDVEVS QPSMEVDVEA PGAKLDGARL EGDLSLADKD 3310 3320 3330 3340 3350 3360 VTAKDSKFKM PKFKMPSYRA SAPGKSIQAS VDVSAPKAEA DVSLPSMQGD LKTTDLSIQL 3370 3380 3390 3400 3410 3420 PSVDLEVQAG QVDVKLPEGH VPEGAGLKGH LPKVEMPSFK MPKVDLKSPQ VDIKGPKLDL 3430 3440 3450 3460 3470 3480 KVPKAEVTVP DVEVSLPSVE VDVQAPRAKL DGARLEGDLS LAEKDVTAKD SKFKMPKFKM 3490 3500 3510 3520 3530 3540 PSFGVSAPGR SIEASLDVSA PKVEADVSLS SMQGDLKATD LSIQPPSADL EVQAVQVDVE 3550 3560 3570 3580 3590 3600 LLEGPVPEGA GLKGHLPKVE MPSLKTPKVD LKGPQIDVKG PKLDLKGPKA EVRVPDVEVS 3610 3620 3630 3640 3650 3660 LPSVEVDVQA PKAKLDAGRL EGDLSLADKD VTAKDSKFKM PKFKMPSFRV SAPGKSMEAS 3670 3680 3690 3700 3710 3720 VDVSAPKVEA DVSLPSMQGD LKTTDLSIQP PSADLKVQAG QMDVKLPEGQ VPEGAGLKEH 3730 3740 3750 3760 3770 3780 LPKVEMPSLK MPKVDLKGPQ VDIKGPKLDL KVSKAEVTAP DVEVSLPSVE VDVQAPRAKL 3790 3800 3810 3820 3830 3840 DSAQLEGDLS LADKDVTAKD SKFKMPKFKM PSFGVSAPGK SIEASVHVSA PKVEADVSLP 3850 3860 3870 3880 3890 3900 SMQGDLKTTD LSIQPHSADL TVQARQVDMK LLEGHVPEEA GLKGHLPKVQ MPSFKMPKVD 3910 3920 3930 3940 3950 3960 LKGPEIDIKG PKLDLKDPKV EVTAPDVEVS LPSVEVDVEA PGAKLDGARL EGDLSLADKD 3970 3980 3990 4000 4010 4020 MTAKDSKFKM PKFKMPSFGV SAPGKSMEAS VDVTAPKVEA DVSLPSMQGD LKATDLSVQP 4030 4040 4050 4060 4070 4080 PSADLEVQAG QVDVKLPEGP VPEGASLKGH LPKVQMPSFK MPKVDLKGPQ IDVKGPKLDL 4090 4100 4110 4120 4130 4140 KGPKAEVTAP DVKMSLSSME VDVQAPRAKL DGVQLEGDLS LADKDVTAKD SKFKMPKFKM 4150 4160 4170 4180 4190 4200 PSFGVSAPGK SMEASVDVSE LKAKADVSLP SMQGDLKTTD LSIQSPSADL EVQAGQVDVK 4210 4220 4230 4240 4250 4260 LPEGPLPKGA GLKGHLPKVQ MPCLKMPKVA LKGPQVDVKG PKLDLKGPKA DVMTPVVEVS 4270 4280 4290 4300 4310 4320 LPSMEVDVEA PGAKLDSVRL EGDLSLADKD MTAKDSKFKM PKFKMPSFGV SAPGKSIEAS 4330 4340 4350 4360 4370 4380 LDVSALKVEA DVSLPSMQGD LKTTHLSIQP PSADLEVQAG QEDVKLPEGP VHEGAGLKGH 4390 4400 4410 4420 4430 4440 LPKLQMPSFK VPKVDLKGPQ IDVNVPKLDL KGPKVEVTSP NLDVSLPSME VDIQAPGAKL 4450 4460 4470 4480 4490 4500 DSTRLEGDLS LADKDVTAKD SKFKMPKFKM PSFGMLSPGK SIEVSVDVSA PKMEADMSIP 4510 4520 4530 4540 4550 4560 SMQGDLKTTD LRIQAPSADL EVQAGQVDLK LPEGHMPEVA GLKGHLPKVE MPSFKMPKVD 4570 4580 4590 4600 4610 4620 LKGPQVDVKG PKLDLKGPKA EVMAPDVEVS LPSVETDVQA PGSMLDGARL EGDLSLAHED 4630 4640 4650 4660 4670 4680 VAGKDSKFQG PKLSTSGFEW SSKKVSMSSS EIEGNVTFHE KTSTFPIVES VVHEGDLHDP 4690 4700 4710 4720 4730 4740 SRDGNLGLAV GEVGMDSKFK KLHFKVPKVS FSSTKTPKDS LVPGAKSSIG LSTIPLSSSE 4750 4760 4770 4780 4790 4800 CSSFELQQVS ACSEPSMQMP KVGFAGFPSS RLDLTGPHFE SSILSPCEDV TLTKYQVTVP 4810 4820 4830 4840 4850 4860 RAALAPELAL EIPSGSQADI PLPKTECSTD LQPPEGVPTS QAESHSGPLN SMIPVSLGQV 4870 4880 4890 4900 4910 4920 SFPKFYKPKF VFSVPQMAVP EGDLHAAVGA PVMSPLSPGE RVQCPLPSTQ LPSPGTCVSQ 4930 4940 4950 4960 4970 4980 GPEELVASLQ TSVVAPGEAP SEDADHEGKG SPLKMPKIKL PSFRWSPKKE TGPKVDPECS 4990 5000 5010 5020 5030 5040 VEDSKLSLVL DKDEVAPQSA IHMDLPPERD GEKGRSTKPG FAMPKLALPK MKASKSGVSL 5050 5060 5070 5080 5090 5100 PQRDVDPSLS SATAGGSFQD TEKASSDGGR GGLGATASAT GSEGVNLHRP QVHIPSLGFA 5110 5120 5130 5140 5150 5160 KPDLRSSKAK VEVSQPEADL PLPKHDLSTE GDSRGCGLGD VPVSQPCGEG IAPTPEDPLQ 5170 5180 5190 5200 5210 5220 PSCRKPDAEV LTVESPEEEA MTKYSQESWF KMPKFRMPSL RRSFRDRGGA GKLEVAQTQA 5230 5240 5250 5260 5270 5280 PAATGGEAAA KVKEFLVSGS NVEAAMSLQL PEADAEVTAS ESKSSTDILR CDLDSTGLKL 5290 5300 5310 5320 5330 5340 HLSTAGMTGD ELSTSEVRIH PSKGPLPFQM PGMRLPETQV LPGEIDETPL SKPGHDLASM 5350 5360 5370 5380 5390 5400 EDKTEKWSSQ PEGPLKLKAS STDMPSQISV VNVDQLWEDS VLTVKFPKLM VPRFSFPAPS 5410 5420 5430 5440 5450 5460 SEDDVFIPTV REVQCPEANI DTALCKESPG LWGASILKAG AGVPGEQPVD LNLPLEAPPI 5470 5480 5490 5500 5510 5520 SKVRVHIQGA QVESQEVTIH SIVTPEFVDL SVPRTFSTQI VRESEIPTSE IQTPSYGFSL 5530 5540 5550 5560 5570 5580 LKVKIPEPHT QARVYTTMTQ HSRTQEGTEE APIQATPGVD SISGDLQPDT GEPFEMISSS 5590 5600 5610 5620 5630 5640 VNVLGQQTLT FEVPSGHQLA DSCSDEEPAE ILEFPPDDSQ EATTPLADEG RAPKDKPESK 5650 5660 5670 5680 5690 5700 KSGLLWFWLP NIGFSSSVDE TGVDSKNDVQ RSAPIQTQPE ARPEAELPKK QEKAGWFRFP 5710 5720 5730 5740 5750 5760 KLGFSSSPTK KSKSTEDGAE LEEQKLQEET ITFFDARESF SPEEKEEGEL IGPVGTGLDS 5770 5780 5790 RVMVTSAART ELILPEQDRK ADDESKGSGL GPNEG
	Isoform 2 [UniParc]. Checksum: E2543EB1BE640F9A		793	85,128
	10 20 30 40 50 60 MDLPPERDGE KGRSTKPGFA MPKLALPKMK ASKSGVSLPQ RDVDPSLSSA TAGGSFQDTE 70 80 90 100 110 120 KASSDGGRGG LGATASATGS EGVNLHRPQV HIPSLGFAKP DLRSSKAKVE VSQPEADLPL 130 140 150 160 170 180 PKHDLSTEGD SRGCGLGDVP VSQPCGEGIA PTPEDPLQPS CRKPDAEVLT VESPEEEAMT 190 200 210 220 230 240 KYSQESWFKM PKFRMPSLRR SFRDRGGAGK LEVAQTQAPA ATGGEAAAKV KEFLVSGSNV 250 260 270 280 290 300 EAAMSLQLPE ADAEVTASES KSSTDILRCD LDSTGLKLHL STAGMTGDEL STSEVRIHPS 310 320 330 340 350 360 KGPLPFQMPG MRLPETQVLP GEIDETPLSK PGHDLASMED KTEKWSSQPE GPLKLKASST 370 380 390 400 410 420 DMPSQISVVN VDQLWEDSVL TVKFPKLMVP RFSFPAPSSE DDVFIPTVRE VQCPEANIDT 430 440 450 460 470 480 ALCKESPGLW GASILKAGAG VPGEQPVDLN LPLEAPPISK VRVHIQGAQV ESQEVTIHSI 490 500 510 520 530 540 VTPEFVDLSV PRTFSTQIVR ESEIPTSEIQ TPSYGFSLLK VKIPEPHTQA RVYTTMTQHS 550 560 570 580 590 600 RTQEGTEEAP IQATPGVDSI SGDLQPDTGE PFEMISSSVN VLGQQTLTFE VPSGHQLADS 610 620 630 640 650 660 CSDEEPAEIL EFPPDDSQEA TTPLADEGRA PKDKPESKKS GLLWFWLPNI GFSSSVDETG 670 680 690 700 710 720 VDSKNDVQRS APIQTQPEAR PEAELPKKQE KAGWFRFPKL GFSSSPTKKS KSTEDGAELE 730 740 750 760 770 780 EQKLQEETIT FFDARESFSP EEKEEGELIG PVGTGLDSRV MVTSAARTEL ILPEQDRKAD 790 DESKGSGLGP NEG
	Isoform 3 [UniParc]. Checksum: 3EC13F00BECDE25A		5,695	605,648
	10 20 30 40 50 60 MSRPEAVQEA TEVTLKTEVE AGASGYSVTG GGDQGIFVKQ VLKDSSAAKL FNLREGDQLL 70 80 90 100 110 120 STTVFFENIK YEDALKILQY SEPYKVQFKI RRQLPAPQDE EWASSDAQHG PQGKEKEDTD 130 140 150 160 170 180 VADGCRETPT KTLEGDGDQE RLISKPRVGR GRQSQRERLS WPKFQSIKSK RGPGPQRSHS 190 200 210 220 230 240 SSEAYEPRDA HDVSPTSTDT EAQLTVERQE QKAGPGSQRR RKFLNLRFRT GSGQGPSSTG 250 260 270 280 290 300 QPGRGFQSGV GRAGVLEELG PWGDSLEETG AATGSRREER AEQDREVMPA QSMPLPTELG 310 320 330 340 350 360 DPRLCEGTPQ EGGLRAARLH GKTLEGQAQE TAVAQRKPRA QPTPGMSREG EGEGLQSLEI 370 380 390 400 410 420 GIARLSLRDT TEGGTQIGPP EIRVRVHDLK TPKFAFSTEK EPERERRLST PQRGKRQDAS 430 440 450 460 470 480 SKAGTGLKGE EVEGAGWMPG REPTTHAEAQ GDEGDGEEGL QRTRITEEQD KGREDTEGQI 490 500 510 520 530 540 RMPKFKIPSL GWSPSKHTKT GREKATEDTE QGREGEATAT ADRREQRRTE EGLKDKEDSD 550 560 570 580 590 600 SMTNTTKIQL IHDEKRLKKE QILTEKEVAT KDSKFKMPKF KMPLFGASAP GKSMEASVDV 610 620 630 640 650 660 SAPKVEADVS LLSMQGDLKT TDLSVQTPSA DLEVQDGQVD VKLPEGPLPE GASLKGHLPK 670 680 690 700 710 720 VQRPSLKMPK VDLKGPKLDL KGPKAEVTAP DVKMSLSSME VDVQAPRAKL DGARLEGDLS 730 740 750 760 770 780 LADKEVTAKD SKFKMPKFKM PSFGVSAPGK SMEDSVDVSA PKVEADVSLS SMQGDLKATD 790 800 810 820 830 840 LSIQPPSADL EVQAGQVDVK LPEGPVPEGA GPKVHLPKVE MPSFKMPKVD LKGPQIDVKG 850 860 870 880 890 900 PKLDLKGPKA EVTAPDGEVS LPSMEVDVQA QKAKLDGAWL EGDLSLADKD VTAKDSKFKM 910 920 930 940 950 960 PKFKMPSFGV SAPGKSIKAL VDVSAPKVEA DLSLPSMQGD LKTTDLSIQP ASTDLKVQAD 970 980 990 1000 1010 1020 QVDVKLPEGH LPEGAGLKGH LPKVEMPSFK MPKVALKGPQ VDVKGPKLDL KSPKAEVTAP 1030 1040 1050 1060 1070 1080 DVEVSLPSVE VDVEAPGAKL DSARLEGELS LADKDVTAKD SRFKMPKFKM PSFGASAPGK 1090 1100 1110 1120 1130 1140 SIEASVDVSA PKVEADVSLP SMQGDLKTTD LSIQPPSADL EVHAGQVDVK LLEGHVPEGA 1150 1160 1170 1180 1190 1200 GFKGHLPKVQ MPSLKMPKVD LKGPQVEVRG PKLDLKGHKA EVTAHEVAVS LPSVEVDMQA 1210 1220 1230 1240 1250 1260 PGAKLDGAQL DGDLSLADKD VTAKDSKFKM PKFKMPSFGV SAPGKSIEAS VDLSAPKVEA 1270 1280 1290 1300 1310 1320 DMSLPSMQGD LKTTDLSIQP PSTDLELQAG QLDVKLPEGP VPEGAGLKGH LPKLQMPSFK 1330 1340 1350 1360 1370 1380 VPKVDLKGPE IDIKGPKLDL KDPKVEVTAP DVEVSLPSVE VDVEAPGAKL DGGRLEEDMS 1390 1400 1410 1420 1430 1440 LADKDLTTKD SKFKMPKFKM PSFGVSAPGK SIEASVDVSA PKVEADVSLP SMQGDLKATD 1450 1460 1470 1480 1490 1500 LSIQPPSADL EVQAGQVDVK LPEGPVSEGA GLKGHLPKVQ MPSFKMPKVD LKGPQIDVKG 1510 1520 1530 1540 1550 1560 PKLDLKGPKV EVTAPDVKMS LSSMEVDVQA PRAKLDGAQL EGDLSLADKA VTAKDSKFKM 1570 1580 1590 1600 1610 1620 PKFKMPSFGV SAPGKSIEAS VDVSEPKVEA DVSLPSMQGD LKTTDLSIQS PSADLEVQAG 1630 1640 1650 1660 1670 1680 QVNVKLPEGP LPEGAGFKGH LPKVQMPSLK MPKVALKGPQ MDVKGPKLDL KGPKAEVMAP 1690 1700 1710 1720 1730 1740 DVEVSLPSVE VDVEAPGAKL DSVRLEGDLS LADKDVTAKD SKFKMPKFKM PSFGVSAPGK 1750 1760 1770 1780 1790 1800 SIEASVDVSA PKVEAEVSLP SMQGDLKTTD LCIPLPSADL VVQAGQVDMK LPEGQVPEGA 1810 1820 1830 1840 1850 1860 GLKGHLPKVD MPSFKMPKVD LKGPQTDVKG AKLDLKGPKA EVTAPDVEVS LPSMEVDVQA 1870 1880 1890 1900 1910 1920 QKAKLDGARL EGDLSLADKD MTAKDSKFKM PKFKMPSFGV SAPGRSIEAS VDVPAPKVEA 1930 1940 1950 1960 1970 1980 DVSLPSMQGD LKTTDLSIQP PSADLKVQTG QVDVKLPEGH VPEGAGLKGH LPKVEMPSLK 1990 2000 2010 2020 2030 2040 MPKVDLKGPQ VDIKGPKLDL KDPKVEMRVP DVEVSLPSME VDVQAPRAKL DSAHLQGDLT 2050 2060 2070 2080 2090 2100 LANKDLTTKD SKFKMPKFKM PSFGVSAPGK SIEASVDVSP PKVEADMSLP SMQGDLKTTD 2110 2120 2130 2140 2150 2160 LSIQPLSADV KVQAGQVDVK LLEGPVPEEV GLKGHLPKLQ MPSFKVPKVD LKGPEIDIKG 2170 2180 2190 2200 2210 2220 PKLDLKDPKV EVTAPDVEVS LPSVEVDVKA PGAKLDGARL EGDMSLADKD VTAKDSKFKM 2230 2240 2250 2260 2270 2280 PKFKMLSFGV SALGKSIEAS ADVSALKVEA DVSLPSMQGD LKTTDLSVQP PSADLEVQAG 2290 2300 2310 2320 2330 2340 QVDVKLPEGP VPEGAGLKGH LPKLQMPSFK MPKVDLKGPQ IDVKGPKLDL KGPKTDVMAP 2350 2360 2370 2380 2390 2400 DVEVSQPSVE VDVEAPGAKL DGAWLEGDLS VADKDVTTKD SRFKIPKFKM PSFGVSAPGK 2410 2420 2430 2440 2450 2460 SIEASVDVSA PKVEADGSLS SMQGDLKATD LSIQPPSADL EVQAGQVDVK LPEGPVPEGA 2470 2480 2490 2500 2510 2520 GLKGHLPKVQ MPSFKMPEMD LKGPQLDVKG PKLDLKGPKA EVTAPDVEMS LSSMEVDVQA 2530 2540 2550 2560 2570 2580 PRAKLDGARL EGDLSLADKG VTAKDSKFKM PKFKMPSFRV SAPGESIEAL VDVSELKVEA 2590 2600 2610 2620 2630 2640 DMSLPSMQGD LKTTDISIQP PSAQLEVQAG QVDVKLPEGH VPEGAGLKGH LPKLQMPSFK 2650 2660 2670 2680 2690 2700 MPEVDLKGPQ IDVKGPNVDL KGPKAEVTAP DVKMSLSSME VDVQAPRAKL DGARLEGDLS 2710 2720 2730 2740 2750 2760 LADKGMTAKD SKFKMPKFKM PSFGVSAPGK SIEASVDVSE LKVEADGSFP SMQGDLKTTD 2770 2780 2790 2800 2810 2820 IRIQPPSAQL EVQAGQVDVK LPEGHVPEGA GLKGHLPKVQ MPSFKMPKVD LKGPQIDVKG 2830 2840 2850 2860 2870 2880 PKLDLKGPKA EVTAPDVEVS LPSVEVDVEA PRAKLDGARL EGDLSLADKD VTAKDSKFKM 2890 2900 2910 2920 2930 2940 PKFKMPSFGV SAPGKSIEVS VDVSAPKVEA EVSLPSMQGD LKTTDISIEP PSAQLEVQAG 2950 2960 2970 2980 2990 3000 QVDLKLPEGH VPEGAGLKGH LPKLQMPSFK MPKVDRKGPQ IDVKGPKLDL KGPKTDVTAP 3010 3020 3030 3040 3050 3060 DVEVSQPGME VDVEAPGAKL DGARLEGDLS LADKDVTAKD SKFKMPKFKM PSFGVSAPGK 3070 3080 3090 3100 3110 3120 SIEVLVDVSA PKVEADLSLP SMQGDLKNTD ISIEPPSAQL EVQAGQVDVK LPEGHVLEGA 3130 3140 3150 3160 3170 3180 GLKGHLPKLQ MPSFKMPKVD RKGPQIDIKG PKLDLKGPKM DVTAPDVEVS QPSMEVDVEA 3190 3200 3210 3220 3230 3240 PGAKLDGARL EGDLSLADKD VTAKDSKFKM PKFKMPSYRA SAPGKSIQAS VDVSAPKAEA 3250 3260 3270 3280 3290 3300 DVSLPSMQGD LKTTDLSIQL PSVDLEVQAG QVDVKLPEGH VPEGAGLKGH LPKVEMPSFK 3310 3320 3330 3340 3350 3360 MPKVDLKSPQ VDIKGPKLDL KVPKAEVTVP DVEVSLPSVE VDVQAPRAKL DGARLEGDLS 3370 3380 3390 3400 3410 3420 LAEKDVTAKD SKFKMPKFKM PSFGVSAPGR SIEASLDVSA PKVEADVSLS SMQGDLKATD 3430 3440 3450 3460 3470 3480 LSIQPPSADL EVQAVQVDVE LLEGPVPEGA GLKGHLPKVE MPSLKTPKVD LKGPQIDVKG 3490 3500 3510 3520 3530 3540 PKLDLKGPKA EVRVPDVEVS LPSVEVDVQA PKAKLDAGRL EGDLSLADKD VTAKDSKFKM 3550 3560 3570 3580 3590 3600 PKFKMPSFRV SAPGKSMEAS VDVSAPKVEA DVSLPSMQGD LKTTDLSIQP PSADLKVQAG 3610 3620 3630 3640 3650 3660 QMDVKLPEGQ VPEGAGLKEH LPKVEMPSLK MPKVDLKGPQ VDIKGPKLDL KVSKAEVTAP 3670 3680 3690 3700 3710 3720 DVEVSLPSVE VDVQAPRAKL DSAQLEGDLS LADKDVTAKD SKFKMPKFKM PSFGVSAPGK 3730 3740 3750 3760 3770 3780 SIEASVHVSA PKVEADVSLP SMQGDLKTTD LSIQPHSADL TVQARQVDMK LLEGHVPEEA 3790 3800 3810 3820 3830 3840 GLKGHLPKVQ MPSFKMPKVD LKGPEIDIKG PKLDLKDPKV EVTAPDVEVS LPSVEVDVEA 3850 3860 3870 3880 3890 3900 PGAKLDGARL EGDLSLADKD MTAKDSKFKM PKFKMPSFGV SAPGKSMEAS VDVTAPKVEA 3910 3920 3930 3940 3950 3960 DVSLPSMQGD LKATDLSVQP PSADLEVQAG QVDVKLPEGP VPEGASLKGH LPKVQMPSFK 3970 3980 3990 4000 4010 4020 MPKVDLKGPQ IDVKGPKLDL KGPKAEVTAP DVKMSLSSME VDVQAPRAKL DGVQLEGDLS 4030 4040 4050 4060 4070 4080 LADKDVTAKD SKFKMPKFKM PSFGVSAPGK SMEASVDVSE LKAKADVSLP SMQGDLKTTD 4090 4100 4110 4120 4130 4140 LSIQSPSADL EVQAGQVDVK LPEGPLPKGA GLKGHLPKVQ MPCLKMPKVA LKGPQVDVKG 4150 4160 4170 4180 4190 4200 PKLDLKGPKA DVMTPVVEVS LPSMEVDVEA PGAKLDSVRL EGDLSLADKD MTAKDSKFKM 4210 4220 4230 4240 4250 4260 PKFKMPSFGV SAPGKSIEAS LDVSALKVEA DVSLPSMQGD LKTTHLSIQP PSADLEVQAG 4270 4280 4290 4300 4310 4320 QEDVKLPEGP VHEGAGLKGH LPKLQMPSFK VPKVDLKGPQ IDVNVPKLDL KGPKVEVTSP 4330 4340 4350 4360 4370 4380 NLDVSLPSME VDIQAPGAKL DSTRLEGDLS LADKDVTAKD SKFKMPKFKM PSFGMLSPGK 4390 4400 4410 4420 4430 4440 SIEVSVDVSA PKMEADMSIP SMQGDLKTTD LRIQAPSADL EVQAGQVDLK LPEGHMPEVA 4450 4460 4470 4480 4490 4500 GLKGHLPKVE MPSFKMPKVD LKGPQVDVKG PKLDLKGPKA EVMAPDVEVS LPSVETDVQA 4510 4520 4530 4540 4550 4560 PGSMLDGARL EGDLSLAHED VAGKDSKFQG PKLSTSGFEW SSKKVSMSSS EIEGNVTFHE 4570 4580 4590 4600 4610 4620 KTSTFPIVES VVHEGDLHDP SRDGNLGLAV GEVGMDSKFK KLHFKVPKVS FSSTKTPKDS 4630 4640 4650 4660 4670 4680 LVPGAKSSIG LSTIPLSSSE CSSFELQQVS ACSEPSMQMP KVGFAGFPSS RLDLTGPHFE 4690 4700 4710 4720 4730 4740 SSILSPCEDV TLTKYQVTVP RAALAPELAL EIPSGSQADI PLPKTECSTD LQPPEGVPTS 4750 4760 4770 4780 4790 4800 QAESHSGPLN SMIPVSLGQV SFPKFYKPKF VFSVPQMAVP EGDLHAAVGA PVMSPLSPGE 4810 4820 4830 4840 4850 4860 RVQCPLPSTQ LPSPGTCVSQ GPEELVASLQ TSVVAPGEAP SEDADHEGKG SPLKMPKIKL 4870 4880 4890 4900 4910 4920 PSFRWSPKKE TGPKVDPECS VEDSKLSLVL DKDEVAPQSA IHMDLPPERD GEKGRSTKPG 4930 4940 4950 4960 4970 4980 FAMPKLALPK MKASKSGVSL PQRDVDPSLS SATAGGSFQD TEKASSDGGR GGLGATASAT 4990 5000 5010 5020 5030 5040 GSEGVNLHRP QVHIPSLGFA KPDLRSSKAK VEVSQPEADL PLPKHDLSTE GDSRGCGLGD 5050 5060 5070 5080 5090 5100 VPVSQPCGEG IAPTPEDPLQ PSCRKPDAEV LTVESPEEEA MTKYSQESWF KMPKFRMPSL 5110 5120 5130 5140 5150 5160 RRSFRDRGGA GKLEVAQTQA PAATGGEAAA KVKEFLVSGS NVEAAMSLQL PEADAEVTAS 5170 5180 5190 5200 5210 5220 ESKSSTDILR CDLDSTGLKL HLSTAGMTGD ELSTSEVRIH PSKGPLPFQM PGMRLPETQV 5230 5240 5250 5260 5270 5280 LPGEIDETPL SKPGHDLASM EDKTEKWSSQ PEGPLKLKAS STDMPSQISV VNVDQLWEDS 5290 5300 5310 5320 5330 5340 VLTVKFPKLM VPRFSFPAPS SEDDVFIPTV REVQCPEANI DTALCKESPG LWGASILKAG 5350 5360 5370 5380 5390 5400 AGVPGEQPVD LNLPLEAPPI SKVRVHIQGA QVESQEVTIH SIVTPEFVDL SVPRTFSTQI 5410 5420 5430 5440 5450 5460 VRESEIPTSE IQTPSYGFSL LKVKIPEPHT QARVYTTMTQ HSRTQEGTEE APIQATPGVD 5470 5480 5490 5500 5510 5520 SISGDLQPDT GEPFEMISSS VNVLGQQTLT FEVPSGHQLA DSCSDEEPAE ILEFPPDDSQ 5530 5540 5550 5560 5570 5580 EATTPLADEG RAPKDKPESK KSGLLWFWLP NIGFSSSVDE TGVDSKNDVQ RSAPIQTQPE 5590 5600 5610 5620 5630 5640 ARPEAELPKK QEKAGWFRFP KLGFSSSPTK KSKSTEDGAE LEEQKLQEET ITFFDARESF 5650 5660 5670 5680 5690 SPEEKEEGEL IGPVGTGLDS RVMVTSAART ELILPEQDRK ADDESKGSGL GPNEG

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