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Reviewed, UniProtKB/Swiss-Prot Q8IVF6 (AN18A_HUMAN)

Last modified July 22, 2008. Version 45. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Ankyrin repeat domain-containing protein 18A
Gene names
Name: ANKRD18A
Synonyms: KIAA2015
OrganismHomo sapiens (Human)
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

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Protein attributes

Sequence length992 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

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General annotation (Comments)

Sequence similarities

Contains 5 ANK repeats.

Sequence caution

The sequence AAH56266.1 differs from that shown. Reason: Miscellaneous discrepancy. Contaminating sequence. Potential poly-A sequence.

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Ontologies

Keywords

   DomainANK repeat
Coiled coil
Repeat
   PTMPhosphoprotein

Gene Ontology (GO)

None. [Check GOA]

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical view

Molecule processing

Chain1 – 992992Ankyrin repeat domain-containing protein 18A

Regions

Repeat67 – 9630ANK 1
Repeat100 – 12930ANK 2
Repeat133 – 16230ANK 3
Repeat166 – 19530ANK 4
Repeat199 – 22830ANK 5
Coiled coil278 – 31033 Potential
Coiled coil378 – 618241 Potential
Coiled coil683 – 71331 Potential
Coiled coil743 – 899157 Potential

Amino acid modifications

Modified residue8691Phosphothreonine

Experimental info

Sequence conflict1301E → K in BAC23111. Ref.1
Sequence conflict1301E → K in AAI52435. Ref.3
Sequence conflict2881Missing in AAH56266. Ref.3
Sequence conflict7271S → N in BAC23111. Ref.1
Sequence conflict7271S → N in AAI52435. Ref.3
Sequence conflict8971A → V in BAC23111. Ref.1
Sequence conflict8971A → V in AAI52435. Ref.3
Sequence conflict9001G → A in BAC23111. Ref.1
Sequence conflict9001G → A in AAI52435. Ref.3

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Sequences

Sequence LengthMass (Da)Tools
Q8IVF6-1 [UniParc].

Last modified February 5, 2008. Version 3.
Checksum: 26B05E166B7D6DD0

FASTA992115,597
        10         20         30         40         50         60 
MRKLFSFGRR LGQALLSSMD QEYAGPGYDI RDWELRKIHR AAIKGDAAEV ERCLTRRFRD 

        70         80         90        100        110        120 
LDARDRKDRT VLHLACAHGR VQVVTLLLHR RCQIDICDRL NRTPLMKAVH SQEEACAIVL 

       130        140        150        160        170        180 
LECGANPNIE DIYGNTALHY AVYNKGTSLA ERLLSHHANI EALNKEGNTP LLFAINSRRQ 

       190        200        210        220        230        240 
HMVEFLLKNQ ANIHAVDNFK RTALILAVQH NLSSIVTLLL QQNIRISSQD MFGQTAEDYA 

       250        260        270        280        290        300 
LCSDLRSIRQ QILEHKNKML KNHLRNDNQE TAAMKPANLK KRKERAKAEH NLKVASEEKQ 

       310        320        330        340        350        360 
ERLQRSENKQ PQDSQSYGKK KDAMYGNFML KKDIAMLKEE LYAIKNDSLR KEKKYIQEIK 

       370        380        390        400        410        420 
SITEINANFE KSVRLNEKMI TKTVARYSQQ LNDLKAENAR LNSELEKEKH NKERLEAEVE 

       430        440        450        460        470        480 
SLHSSLATAI NEYNEIVERK DLELVLWRAD DVSRHEKMGS NISQLTDKNE LLTEQVHKAR 

       490        500        510        520        530        540 
VKFNTLKGKL RETRDALREK TLALGSVQLD LRQAQHRIKE MKQMHPNGEA KESQSIGKQN 

       550        560        570        580        590        600 
SLEERIRQQE LENLLLERQL EDARKEGDNK EIVINIHRDC LENGKEDLLE ERNKELMKEY 

       610        620        630        640        650        660 
NYLKEKLLQC EKEKAEREVI VREFQEELVD HLKTFSISES PLEGTSHCHI NLNETWTSKK 

       670        680        690        700        710        720 
KLFQVEIQPE EKHEEFRKLF ELISLLNYTA DQIRKKNREL EEEATGYKKC LEMTINMLNA 

       730        740        750        760        770        780 
FANEDFSCHG DLNTDQLKMD ILFKKLKQKF NDLVAEKEAV SSECVNLAKD NEVLHQELLS 

       790        800        810        820        830        840 
MRNVQEKCEK LEKDKKMLEE EVLNLKTHME KDMVELGKLQ EYKSELDERA VQEIEKLEEI 

       850        860        870        880        890        900 
HLQKQAEYEK QLEQLNKDNT ASLKKKELTL KDVECKFSKM KTAYEEVTTE LEEFKEAFAG 

       910        920        930        940        950        960 
AVKANNSMSK KLMKSDKKIA VISTKLFTEK QRMKYFLSTL PTRPEPELPC VENLNSIELN 

       970        980        990 
RKYIPKTAIR IPTSNPQTSN NCKNFLTEVL LC

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References

[1]"The nucleotide sequence of a long cDNA clone isolated from human."
Nagase T., Kikuno R., Ohara O.
Submitted (NOV-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
[2]"DNA sequence and analysis of human chromosome 9."
Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L. expand/collapse author list , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
Nature 429:369-374(2004) [PubMed: 15164053] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Prostate.
[4]"Phosphoproteome of resting human platelets."
Zahedi R.P., Lewandrowski U., Wiesner J., Wortelkamp S., Moebius J., Schuetz C., Walter U., Gambaryan S., Sickmann A.
J. Proteome Res. 7:526-534(2008) [PubMed: 18088087] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-869, MASS SPECTROMETRY.
Tissue: Platelet.

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Cross-references

Sequence databases

AB095935 mRNA. Translation: BAC23111.1. Different initiation.
AL591543 Genomic DNA. Translation: CAI17285.1.
BC056266 mRNA. Translation: AAH56266.1. Sequence problems.
BC152434 mRNA. Translation: AAI52435.1.
UniGeneHs.561966
Hs.644630

3D structure databases

ModBaseSearch...

Genome annotation databases

EnsemblENSG00000180071. Homo sapiens. [Contig view]

Organism-specific databases

HGNCHGNC:23643. ANKRD18A.
PharmGKBPA134889624.
HUGESearch...
GenAtlasSearch...
GeneCardsSearch...

Phylogenomic databases

HOGENOMQ8IVF6.
HOVERGENQ8IVF6.

Gene expression databases

ArrayExpressQ8IVF6.
CleanExHS_ANKRD18A.
GermOnlineENSG00000180071. Homo sapiens.

Family and domain databases

InterProIPR002110. ANK.
[Graphical view]
Gene3DG3DSA:1.25.40.20. ANK. 1 hit.
PfamPF00023. Ank. 6 hits.
[Graphical view]
PRINTSPR01415. ANKYRIN.
SMARTSM00248. ANK. 6 hits.
[Graphical view]
PROSITEPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 3 hits.
[Graphical view]
ProDomQ8IVF6.
[Graphical view] [Entries sharing at least one domain]
BLOCKSSearch...

Other Resources

ProtoNetSearch...

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Entry information

Entry nameAN18A_HUMAN
AccessionPrimary (citable) accession number: Q8IVF6
Secondary accession number(s): A7MD11 expand/collapse secondary AC list , A8MVU5, Q5SY86, Q7Z468
Entry history
Integrated into UniProtKB/Swiss-Prot: December 15, 2003
Last sequence update: February 5, 2008
Last modified: July 22, 2008
This is version 45 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

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Relevant documents

Human chromosome 9

Human chromosome 9: entries, gene names and cross-references to MIM

UniProtKB secondary accession numbers

Index of UniProtKB secondary accession numbers

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents