Reviewed, UniProtKB/Swiss-Prot Q8KA28 (FABB_BUCAP)

Names and origin

Protein names

Recommended name:
    3-oxoacyl-[acyl-carrier-protein] synthase 1
    EC=2.3.1.41
Alternative name(s):
    3-oxoacyl-[acyl-carrier-protein] synthase I
    Beta-ketoacyl-ACP synthase I
      Short name(s)=KAS I

Gene names

Name:	fabB
Ordered Locus Names:	BUsg_084

Organism

Buchnera aphidicola subsp. Schizaphis graminum [Complete proteome] [HAMAP]

Taxonomic identifier

98794 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Buchnera

Protein attributes

Sequence length	407 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Specific for elongation from C-10 to unsaturated C-16 and C-18 fatty acids By similarity.
Catalytic activity	Acyl-[acyl-carrier-protein] + malonyl-[acyl-carrier-protein] = 3-oxoacyl-[acyl-carrier-protein] + CO(2) + [acyl-carrier-protein].
Pathway	Lipid metabolism; fatty acid biosynthesis.
Subunit structure	Homodimer By similarity.
Subcellular location	CytoplasmBy similarity.
Sequence similarities	Belongs to the beta-ketoacyl-ACP synthases family.

Ontologies

Keywords
Biological process	Fatty acid biosynthesis Lipid synthesis
Cellular component	Cytoplasm
Molecular function	Acyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Molecular function	3-oxoacyl-[acyl-carrier-protein] synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view
Molecule processing
	Chain	1 – 407	407	3-oxoacyl-[acyl-carrier-protein] synthase 1
Sites
	Active site	164	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q8KA28-1 [UniParc]. Last modified October 1, 2002. Version 1. Checksum: CBCFC30445A34679	FASTA	407	44,523
	10 20 30 40 50 60 MKRVVITGFG IISSIGNNKK EVLNSLYNGI SGITFSEEMK ESGMRSQVWG NIKLENKKFF 70 80 90 100 110 120 KKNKISRFMN NGSIYAFLSM EQAIKDANLQ TKQYQKNPRI GIIAGSGGGF PKYHIQGIDA 130 140 150 160 170 180 IRSNRGLNSV SPYIAIKAMN SGISACLSTL FKIYGVNYSI SSACATSGHC IGNAFELIKF 190 200 210 220 230 240 GKQDLIFAGG GEEVSWELAY EFDAMKALSS NFNKNPTKSS RVYDVNRDGF VISGGGGIIV 250 260 270 280 290 300 IEELNCALSR SAHIYAEIIG YAATSDGKDM VVPSGDGAVR CMNLAKKQNK MLFIDYLNVH 310 320 330 340 350 360 GTSTKIGDLI ELEAIKKSFF HEKKPMISAT KSMTGHALGV SGVHEIIYTL LMMKYNFIAP 370 380 390 400 SINIETIEPS ADNMNIVQKT FHKKIKTALS NSFGFGGTNV SLILKKY

References

[1]

"50 million years of genomic stasis in endosymbiotic bacteria." Tamas I., Klasson L., Canbaeck B., Naeslund A.K., Eriksson A.-S., Wernegreen J.J., Sandstroem J.P., Moran N.A., Andersson S.G.E. Science 296:2376-2379(2002) [PubMed: 12089438] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE013218 Genomic DNA. Translation: AAM67654.1.
RefSeq	NP_660443.1.
3D structure databases
HSSP	HSSP built from PDB template 1DD8 based on UniProtKB P14926.
ModBase	Search...
Genome annotation databases
GeneID	1005901.
GenomeReviews	Gene locus BUsg_084 in contig AE013218_GR.
KEGG	bas:BUsg084.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q8KA28.
Enzyme and pathway databases
BioCyc	BAPH198804:BUSG084-MON.
Family and domain databases
InterPro	IPR000794. Ketoacyl_synth. IPR014031. Ketoacyl_synth_C. IPR014030. Ketoacyl_synth_N. IPR016038. Thiolase-like_subgr. [Graphical view]
Gene3D	G3DSA:3.40.47.10. Thiolase-like_subgr. 2 hits.
PANTHER	PTHR11712. Ketoacyl_synth. 1 hit.
Pfam	PF00109. ketoacyl-synt. 1 hit. PF02801. Ketoacyl-synt_C. 1 hit. [Graphical view]
PROSITE	PS00606. B_KETOACYL_SYNTHASE. 1 hit. [Graphical view]
ProDom	Q8KA28. [Graphical view] [Entries sharing at least one domain]
BLOCKS	Search...
Other Resources
ProtoNet	Search...

Entry information

Entry name

FABB_BUCAP

Accession

Primary (citable) accession number: Q8KA28

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 8, 2002
Last sequence update:	October 1, 2002
Last modified:	July 22, 2008
This is version 41 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)