Reviewed, UniProtKB/Swiss-Prot Q8KA49 (PTHP_BUCAP)

Names and origin

Protein names

Recommended name:
    Phosphocarrier protein HPr
    EC=2.7.11.-
Alternative name(s):
    Histidine-containing protein

Gene names

Name:	ptsH
Ordered Locus Names:	BUsg_062

Organism

Buchnera aphidicola subsp. Schizaphis graminum [Complete proteome] [HAMAP]

Taxonomic identifier

98794 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Buchnera

Protein attributes

Sequence length	85 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The phosphoryl group from phosphoenolpyruvate (PEP) is transferred to the phosphoryl carrier protein HPr by enzyme I. Phospho-HPr then transfers it to the permease (enzymes II/III) By similarity.
Catalytic activity	Protein HPr N(pi)-phospho-L-histidine + protein EIIA = protein HPr + protein EIIA N(tau)-phospho-L-histidine.
Subcellular location	CytoplasmBy similarity.
Sequence similarities	Belongs to the HPr family. Contains 1 HPr domain.

Ontologies

Keywords
Biological process	Phosphotransferase system Sugar transport Transport
Cellular component	Cytoplasm
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view
Molecule processing
	Chain	1 – 85	85	Phosphocarrier protein HPr
Regions
	Domain	1 – 85	85	HPr
Sites
	Active site	15	1	Pros-phosphohistidine intermediate By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q8KA49-1 [UniParc]. Last modified October 1, 2002. Version 1. Checksum: 6882A1A6206EAC0E	FASTA	85	9,571
	10 20 30 40 50 60 MFQKEIKINA LHGLHTRPAA EFVKEAKNFI SDIHIIYHGK SVNAKSLFKI QTLGLVKDSV 70 80 IILSAEGEDE KKAVEHLSKI MTELE

References

[1]

"50 million years of genomic stasis in endosymbiotic bacteria." Tamas I., Klasson L., Canbaeck B., Naeslund A.K., Eriksson A.-S., Wernegreen J.J., Sandstroem J.P., Moran N.A., Andersson S.G.E. Science 296:2376-2379(2002) [PubMed: 12089438] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE013218 Genomic DNA. Translation: AAM67633.1.
RefSeq	NP_660422.1.
3D structure databases
HSSP	HSSP built from PDB template 1POH based on UniProtKB P07006.
ModBase	Search...
Genome annotation databases
GeneID	1005878.
GenomeReviews	Gene locus BUsg_062 in contig AE013218_GR.
KEGG	bas:BUsg062.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q8KA49.
Enzyme and pathway databases
BioCyc	BAPH198804:BUSG062-MON.
Family and domain databases
InterPro	IPR005698. PTS_HPr. IPR001020. PTS_HPr_HisP_S. IPR000032. PTS_HPr_protein. IPR002114. PTS_HPr_SerP_S. [Graphical view]
Gene3D	G3DSA:3.30.1340.10. PTS_HPr_protein. 1 hit.
Pfam	PF00381. PTS-HPr. 1 hit. [Graphical view]
PRINTS	PR00107. PHOSPHOCPHPR.
ProDom	PD002238. HPr_protein. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR01003. PTS_HPr_family. 1 hit.
PROSITE	PS51350. PTS_HPR_DOM. 1 hit. PS00369. PTS_HPR_HIS. 1 hit. PS00589. PTS_HPR_SER. 1 hit. [Graphical view]
BLOCKS	Search...
Other Resources
ProtoNet	Search...

Entry information

Entry name

PTHP_BUCAP

Accession

Primary (citable) accession number: Q8KA49

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 8, 2002
Last sequence update:	October 1, 2002
Last modified:	July 22, 2008
This is version 39 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)