Reviewed, UniProtKB/Swiss-Prot Q8N0Z2 (ABRA_HUMAN)

Names and origin

Protein names

Recommended name:
    Actin-binding Rho-activating protein
Alternative name(s):
    Striated muscle activator of Rho-dependent signaling
      Short name(s)=STARS

Gene names

Name:

ABRA

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	381 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Acts as an activator of serum response factor (SRF)-dependent transcription possibly by inducing nuclear translocation of MKL1 or MKL2 and through a mechanism requiring Rho-actin signaling By similarity.
Subunit structure	Binds F-actin and ABLIM1, ABLIM2 AND ABLIM3. Interaction with ABLIM2 AND ABLIM3 enhances activity By similarity.
Subcellular location	Cytoplasm › myofibril › sarcomereBy similarity. Cytoplasm › cytoskeletonBy similarity. Note= Localized to the I-band of the sarcomere and to a lesser extent to the sarcomeric structure between Z-lines By similarity.

Ontologies

Keywords
Biological process	Protein transport Transcription Transcription regulation Translocation Transport
Cellular component	Cytoplasm Cytoskeleton
Ligand	Actin-binding
Molecular function	Activator
Gene Ontology (GO)
Biological process	positive regulation of Rho protein signal transduction Inferred from sequence or structural similarity. Source: HGNC positive regulation of transcription factor activity Inferred from sequence or structural similarity. Source: HGNC
Cellular component	actin cytoskeleton Inferred from sequence or structural similarity. Source: HGNC plasma membrane Inferred from direct assay. Source: LIFEdb sarcomere Inferred from sequence or structural similarity. Source: HGNC
Molecular function	actin binding Inferred from sequence or structural similarity. Source: HGNC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view
Molecule processing
	Chain	1 – 381	381	Actin-binding Rho-activating protein
Regions
	Region	240 – 285	46	Interaction with actin By similarity
	Region	352 – 381	30	Interaction with actin By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q8N0Z2-1 [UniParc]. Last modified October 1, 2002. Version 1. Checksum: AC5B8D4D9A267C46	FASTA	381	43,117
	10 20 30 40 50 60 MAPGEKESGE GPAKSALRKI RTATLVISLA RGWQQWANEN SIRQAQEPTG WLPGGTQDSP 70 80 90 100 110 120 QAPKPITPPT SHQKAQSAPK SPPRLPEGHG DGQSSEKAPE VSHIKKKEVS KTVVSKTYER 130 140 150 160 170 180 GGDVSHLSHR YERDAGVLEP GQPENDIDRI LHSHGSPTRR RKCANLVSEL TKGWRVMEQE 190 200 210 220 230 240 EPTWRSDSVD TEDSGYGGEA EERPEQDGVQ VAVVRIKRPL PSQVNRFTEK LNCKAQQKYS 250 260 270 280 290 300 PVGNLKGRWQ QWADEHIQSQ KLNPFSEEFD YELAMSTRLH KGDEGYGRPK EGTKTAERAK 310 320 330 340 350 360 RAEEHIYREM MDMCFIICTM ARHRRDGKIQ VTFGDLFDRY VRISDKVVGI LMRARKHGLV 370 380 DFEGEMLWQG RDDHVVITLL K

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"STARS, a striated muscle activator of Rho signaling and serum response factor-dependent transcription." Arai A., Spencer J.A., Olson E.N. J. Biol. Chem. 277:24453-24459(2002) [PubMed: 11983702] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Skeletal muscle.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF503617 mRNA. Translation: AAM27268.1. AK092694 mRNA. Translation: BAC03948.1. BC105103 mRNA. Translation: AAI05104.1. BC105105 mRNA. Translation: AAI05106.1.
RefSeq	NP_631905.1.
UniGene	Hs.374668
3D structure databases
ModBase	Search...
PTM databases
PhosphoSite	Q8N0Z2.
Genome annotation databases
Ensembl	ENSG00000174429. Homo sapiens. [Contig view]
GeneID	137735.
KEGG	hsa:137735.
Organism-specific databases
HGNC	HGNC:30655. ABRA.
HPA	HPA017724.
MIM	609747. gene.
GenAtlas	Search...
GeneCards	Search...
GeneLynx	Search...
Phylogenomic databases
HOGENOM	Q8N0Z2.
HOVERGEN	Q8N0Z2.
Gene expression databases
ArrayExpress	Q8N0Z2.
CleanEx	HS_ABRA.
GermOnline	ENSG00000174429. Homo sapiens.
Family and domain databases
ProDom	Q8N0Z2. [Graphical view] [Entries sharing at least one domain]
BLOCKS	Search...
Other Resources
SOURCE	Search...
ProtoNet	Search...

Entry information

Entry name

ABRA_HUMAN

Accession

Primary (citable) accession number: Q8N0Z2

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 25, 2006
Last sequence update:	October 1, 2002
Last modified:	July 22, 2008
This is version 38 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)