Reviewed, UniProtKB/Swiss-Prot Q8N339 (MT1M_HUMAN)

Names and origin

Protein names

Recommended name:
    Metallothionein-1M
      Short name=MT-1M
Alternative name(s):
    Metallothionein-IM
      Short name=MT-IM

Gene names

Name:	MT1M
Synonyms:	MT1K

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	61 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids.
Subunit structure	Monomer By similarity.
Domain	Class I metallothioneins contain 2 metal-binding domains: four divalent ions are chelated within cluster A of the alpha domain and are coordinated via cysteinyl thiolate bridges to 11 cysteine ligands. Cluster B, the corresponding region within the beta domain, can ligate three divalent ions to 9 cysteines.
Sequence similarities	Belongs to the metallothionein superfamily. Type 1 family.

Ontologies

Keywords
Coding sequence diversity	Polymorphism
Ligand	Cadmium Copper Metal-binding Metal-thiolate cluster Zinc
PTM	Acetylation
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view
Molecule processing
	Chain	1 – 61	61	Metallothionein-1M
Regions
	Region	1 – 29	29	Beta
	Region	30 – 61	32	Alpha
Sites
	Metal binding	5	1	Cluster B
	Metal binding	7	1	Cluster B
	Metal binding	13	1	Cluster B
	Metal binding	15	1	Cluster B
	Metal binding	19	1	Cluster B
	Metal binding	21	1	Cluster B
	Metal binding	24	1	Cluster B
	Metal binding	26	1	Cluster B
	Metal binding	29	1	Cluster B
	Metal binding	33	1	Cluster A
	Metal binding	34	1	Cluster A
	Metal binding	36	1	Cluster A
	Metal binding	37	1	Cluster A
	Metal binding	41	1	Cluster A
	Metal binding	44	1	Cluster A
	Metal binding	48	1	Cluster A
	Metal binding	50	1	Cluster A
	Metal binding	57	1	Cluster A
	Metal binding	59	1	Cluster A
	Metal binding	60	1	Cluster A
Amino acid modifications
	Modified residue	1	1	N-acetylmethionine By similarity
Natural variations
	Natural variant	20	1	T → K: dbSNP rs1827210.

Sequences

	Sequence		Length	Mass (Da)
	Q8N339-1 [UniParc]. Last modified February 7, 2006. Version 2. Checksum: 754753ED088411CE	FASTA	61	6,110
	10 20 30 40 50 60 MDPNCSCTTG VSCACTGSCT CKECKCTSCK KSCCSCCPVG CAKCAHGCVC KGTLENCSCC A

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning of a new human cDNA homologous to monkey metallothionein." Li N.G., Yu L., Zhao S.Y. Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT LYS-20.
[2]	"Cloning of a novel member of the MT gene family -- MT1M." Wang J., Yu L., Zhao S. Submitted (FEB-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT LYS-20. Tissue: Colon.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF136177 mRNA. Translation: AAP97267.1. AF348671 Genomic DNA. Translation: AAL83902.1. BC028280 mRNA. Translation: AAH28280.1. BC103841 mRNA. Translation: AAI03842.1.
RefSeq	NP_789846.1.
UniGene	Hs.647370
3D structure databases
HSSP	HSSP built from PDB template 2MHU based on UniProtKB P02795.
ModBase	Search...
Genome annotation databases
Ensembl	ENSG00000205364. Homo sapiens. [Contig view]
GeneID	4499.
KEGG	hsa:4499.
Organism-specific databases
HGNC	HGNC:14296. MT1M.
PharmGKB	PA142671312.
GenAtlas	Search...
GeneCards	Search...
Phylogenomic databases
HOGENOM	Q8N339.
HOVERGEN	Q8N339.
Gene expression databases
ArrayExpress	Q8N339.
CleanEx	HS_MT1M.
GermOnline	ENSG00000205364. Homo sapiens.
Family and domain databases
InterPro	IPR015874. 4-disulphide_core. IPR002400. GF_cysknot. IPR003019. Metallothionein_sfam_euk. IPR000006. Metallothionein_vert. [Graphical view]
Gene3D	G3DSA:4.10.10.10. Metallothionein_vert. 1 hit.
PANTHER	PTHR23299. Metallothionein_vert. 1 hit.
Pfam	PF00131. Metallothio. 1 hit. [Graphical view]
PRINTS	PR00003. 4DISULPHCORE. PR00438. GFCYSKNOT. PR00860. MTVERTEBRATE.
PROSITE	PS00203. METALLOTHIONEIN_VRT. 1 hit. [Graphical view]
ProDom	Q8N339. [Graphical view] [Entries sharing at least one domain]
BLOCKS	Search...
Other Resources
ProtoNet	Search...

Entry information

Entry name

MT1M_HUMAN

Accession

Primary (citable) accession number: Q8N339
Secondary accession number(s): Q8TDN3

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 7, 2006
Last sequence update:	February 7, 2006
Last modified:	July 22, 2008
This is version 50 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)