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Reviewed, UniProtKB/Swiss-Prot Q8NFQ5 (BPIL3_HUMAN)

Last modified November 4, 2008. Version 45. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Bactericidal/permeability-increasing protein-like 3
Gene names
Name: BPIL3
OrganismHomo sapiens (Human)
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

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Protein attributes

Sequence length453 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level.

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General annotation (Comments)

Subcellular location

SecretedBy similarity.

Tissue specificity

Detected at very low levels in normal tonsils, and at higher levels in hypertrophic tonsils.

Sequence similarities

Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.

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Ontologies

Keywords

   Cellular componentSecreted
   Coding sequence diversityPolymorphism
   DomainSignal
   PTMGlycoprotein

Gene Ontology (GO)

   Cellular componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1818 Potential
Chain19 – 453435Bactericidal/permeability-increasing protein-like 3
PRO_0000017168

Amino acid modifications

Glycosylation1141N-linked (GlcNAc...) Potential
Glycosylation1901N-linked (GlcNAc...) Potential

Natural variations

Natural variant161T → M: dbSNP rs17301126.
VAR_033632
Natural variant971V → I: dbSNP rs2070317.
VAR_024518
Natural variant1491P → T: dbSNP rs11907355.
VAR_033633
Natural variant3471S → G: dbSNP rs4911287.
VAR_033634

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Sequences

Sequence LengthMass (Da)Tools
Q8NFQ5-1 [UniParc].

Last modified October 1, 2002. Version 1.
Checksum: 19379CA22A41CE5C

FASTA45349,717
        10         20         30         40         50         60 
MLRILCLALC SLLTGTRADP GALLRLGMDI MNQVQSAMDE SHILEKMAAE AGKKQPGMKP 

        70         80         90        100        110        120 
IKGITNLKVK DVQLPVITLN FVPGVGIFQC VSTGMTVTGK SFMGGNMEII VALNITATNR 

       130        140        150        160        170        180 
LLRDEETGLP VFKSEGCEVI LVNVKTNLPS NMLPKMVNKF LDSTLHKVLP GLMCPAIDAV 

       190        200        210        220        230        240 
LVYVNRKWTN LSDPMPVGQM GTVKYVLMSA PATTASYIQL DFSPVVQQQK GKTIKLADAG 

       250        260        270        280        290        300 
EALTFPEGYA KGSSQLLLPA TFLSAELALL QKSFHVNIQD TMIGELPPQT TKTLARFIPE 

       310        320        330        340        350        360 
VAVAYPKSKP LTTQIKIKKP PKVTMKTGKS LLHLHSTLEM FAARWRSKAP MSLFLLEVHF 

       370        380        390        400        410        420 
NLKVQYSVHE NQLQMATSLD RLLSLSRKSS SIGNFNEREL TGFITSYLEE AYIPVVNDVL 

       430        440        450 
QVGLPLPDFL AMNYNLAELD IVENALMLDL KLG

« Hide

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References

« Hide 'large scale' references
[1]"Three new human members of the lipid transfer/lipopolysaccharide binding protein family (LT/LBP)."
Mulero J.J., Boyle B.J., Bradley S., Bright J.M., Nelken S.T., Ho T.T., Mize N.K., Childs J.D., Ballinger D.G., Ford J.E., Rupp F.
Immunogenetics 54:293-300(2002) [PubMed: 12185532] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Tonsil.
[2]"The DNA sequence and comparative analysis of human chromosome 20."
Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E. expand/collapse author list , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
Nature 414:865-871(2001) [PubMed: 11780052] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

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Cross-references

Sequence databases

AF465767 mRNA. Translation: AAM73985.1.
AL121756 Genomic DNA. Translation: CAI22530.1.
RefSeqNP_777557.1.
UniGeneHs.375090

3D structure databases

ModBaseSearch...

Genome annotation databases

EnsemblENSG00000167104. Homo sapiens. [Contig view]
GeneID128859.
KEGGhsa:128859.

Organism-specific databases

H-InvDBHIX0040526.
HGNCHGNC:16504. BPIL3.
PharmGKBPA25406.
GenAtlasSearch...
GeneCardsSearch...

Phylogenomic databases

HOGENOMQ8NFQ5.
HOVERGENQ8NFQ5.

Gene expression databases

ArrayExpressQ8NFQ5.
CleanExHS_BPIL3.
GermOnlineENSG00000167104. Homo sapiens.

Family and domain databases

InterProIPR001124. LBP_BPI_CETP.
[Graphical view]
PfamPF01273. LBP_BPI_CETP. 1 hit.
PF02886. LBP_BPI_CETP_C. 1 hit.
[Graphical view]
SMARTSM00328. BPI1. 1 hit.
SM00329. BPI2. 1 hit.
[Graphical view]
PROSITEPS00400. LBP_BPI_CETP. False negative.
[Graphical view]
BLOCKSSearch...
ProtoNetSearch...

Other Resources

NextBio82486.

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Entry information

Entry nameBPIL3_HUMAN
AccessionPrimary (citable) accession number: Q8NFQ5
Entry history
Integrated into UniProtKB/Swiss-Prot: August 29, 2003
Last sequence update: October 1, 2002
Last modified: November 4, 2008
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

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Relevant documents

Human chromosome 20

Human chromosome 20: entries, gene names and cross-references to MIM

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents