Reviewed, UniProtKB/Swiss-Prot Q8R570 (CA142_MOUSE)

Names and origin

Protein names	Recommended name:     t-SNARE coiled-coil homology domain-containing protein C1orf142 homolog
Organism	Mus musculus (Mouse)
Taxonomic identifier	10090 [NCBI]
Taxonomic lineage	Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

Protein attributes

Sequence length	413 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Sequence similarities	Belongs to the SVAP1 family. Contains 2 t-SNARE coiled-coil homology domains.
Sequence caution	The sequence BAC35874.1 differs from that shown. Reason: Frameshift at positions 312 and 330.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing
Domain	Coiled coil Repeat
Gene Ontology (GO)
None. [Check GOA]

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q8R570-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q8R570-2)

The sequence of this isoform differs from the canonical sequence as follows:
     326-333: RPKGCTPH → CHLFLIIS
     334-413: Missing.

Notes: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view
Molecule processing
	Chain	1 – 413	413	t-SNARE coiled-coil homology domain-containing protein C1orf142 homolog
Regions
	Domain	109 – 171	63	t-SNARE coiled-coil homology 1
	Domain	350 – 412	63	t-SNARE coiled-coil homology 2
Natural variations
	Alternative sequence	326 – 333	8	RPKGCTPH → CHLFLIIS in isoform 2.
	Alternative sequence	334 – 413	80	Missing in isoform 2.
Experimental info
	Sequence conflict	355	1	F → S in BAC35874. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified June 1, 2002. Version 1. Checksum: A923C061BE7E569D	FASTA	413	46,524
	10 20 30 40 50 60 MSSDMRVHSW SCSYYLDLEK QWVSGKLTLT PHSLKFIVEK TEEVLVGLPL SSIIEIRKES 70 80 90 100 110 120 SLFIFGAITV LEKGQTKHWF SSLQPSRNVV FNVIEHFWRE LLLSQPGTAA NIPSHVTRGQ 130 140 150 160 170 180 ELIGLMANSQ KRMEDTAKDL QQQSEQLDSV LKGLEKMESD LDVADRLLTE LETPSWWPFG 190 200 210 220 230 240 SKFWKMPAEE NLKEGVSSTC EPFGKEGVVI TVPAIISERA ESHSKLGKLT VLVSALEIYD 250 260 270 280 290 300 SCSLLLHRFE KEDVDDIKVH SPYEVSIRQR FIGKPDVAYQ LISAKMPEVI PILEVQFSSK 310 320 330 340 350 360 IELLEDALVL RNKVFASSAE RHAASRPKGC TPHRELPTGG QEGEQLQLQK NLPLFSEGEA 370 380 390 400 410 QELTQILSKM KGLALDTEAE LERQDAALDG ITVAVDRATL NVDKQNRRMR KLM
	Isoform 2 [UniParc]. Checksum: AAB32C4F9FBA3175		333	37,642
	10 20 30 40 50 60 MSSDMRVHSW SCSYYLDLEK QWVSGKLTLT PHSLKFIVEK TEEVLVGLPL SSIIEIRKES 70 80 90 100 110 120 SLFIFGAITV LEKGQTKHWF SSLQPSRNVV FNVIEHFWRE LLLSQPGTAA NIPSHVTRGQ 130 140 150 160 170 180 ELIGLMANSQ KRMEDTAKDL QQQSEQLDSV LKGLEKMESD LDVADRLLTE LETPSWWPFG 190 200 210 220 230 240 SKFWKMPAEE NLKEGVSSTC EPFGKEGVVI TVPAIISERA ESHSKLGKLT VLVSALEIYD 250 260 270 280 290 300 SCSLLLHRFE KEDVDDIKVH SPYEVSIRQR FIGKPDVAYQ LISAKMPEVI PILEVQFSSK 310 320 330 IELLEDALVL RNKVFASSAE RHAASCHLFL IIS

References

[1]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2). Strain: C3H and C57BL/6J. Tissue: Brain, Cerebellum, Embryo and Embryonic stem cell.
[2]	The mouse genome sequencing consortium Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C57BL/6J.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Strain: Czech II and FVB/N. Tissue: Mammary tumor.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AK028053 mRNA. Translation: BAC25723.1. AK049330 mRNA. Translation: BAC33686.1. AK075640 mRNA. Translation: BAC35874.1. Frameshift. AK144165 mRNA. Translation: BAE25743.1. AL713994 Genomic DNA. Translation: CAI25399.1. BC023182 mRNA. Translation: AAH23182.1. BC029025 mRNA. Translation: AAH29025.1.
RefSeq	NP_653104.1.
UniGene	Mm.26680
3D structure databases
ModBase	Search...
Genome annotation databases
Ensembl	ENSMUSG00000009894. Mus musculus. [Contig view]
GeneID	67826.
KEGG	mmu:67826.
Organism-specific databases
MGI	MGI:1915076. 1110031B06Rik.
Phylogenomic databases
HOGENOM	Q8R570.
HOVERGEN	Q8R570.
Gene expression databases
ArrayExpress	Q8R570.
CleanEx	MM_1110031B06RIK.
Family and domain databases
InterPro	IPR000727. T_SNARE. [Graphical view]
PROSITE	PS50192. T_SNARE. 2 hits. [Graphical view]
ProDom	Q8R570. [Graphical view] [Entries sharing at least one domain]
BLOCKS	Search...
Other Resources
ProtoNet	Search...

Entry information

Entry name

CA142_MOUSE

Accession

Primary (citable) accession number: Q8R570
Secondary accession number(s): Q3UNK4, Q8BK87

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 23, 2007
Last sequence update:	June 1, 2002
Last modified:	July 22, 2008
This is version 43 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)