Reviewed, UniProtKB/Swiss-Prot Q8TE56 (ATS17_HUMAN)

Names and origin

Protein names

Recommended name:
    A disintegrin and metalloproteinase with thrombospondin motifs 17
      Short name=ADAMTS-17
      Short name=ADAM-TS 17
      Short name=ADAM-TS17
    EC=3.4.24.-

Gene names

Name:

ADAMTS17

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	1095 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Subcellular location	Secreted › extracellular space › extracellular matrixBy similarity.
Tissue specificity	Expressed in fetal lung, in adult brain, prostate, and liver.
Domain	The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
Post-translational modification	The precursor is cleaved by a furin endopeptidase By similarity.
Sequence similarities	Contains 1 disintegrin domain. Contains 1 peptidase M12B domain. Contains 1 PLAC domain. Contains 5 TSP type-1 domains.

Ontologies

Keywords
Cellular component	Extracellular matrix Secreted
Domain	Repeat Signal
Ligand	Metal-binding Zinc
Molecular function	Hydrolase Metalloprotease Protease
PTM	Cleavage on pair of basic residues Glycoprotein Zymogen
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view
Molecule processing
	Signal peptide	1 – 27	27	Potential
	Propeptide	28 – 223	196	By similarity
	Chain	224 – 1095	872	A disintegrin and metalloproteinase with thrombospondin motifs 17
Regions
	Domain	232 – 452	221	Peptidase M12B
	Domain	453 – 542	90	Disintegrin
	Domain	543 – 598	56	TSP type-1 1
	Domain	800 – 860	61	TSP type-1 2
	Domain	861 – 922	62	TSP type-1 3
	Domain	925 – 968	44	TSP type-1 4
	Domain	972 – 1029	58	TSP type-1 5
	Domain	1045 – 1084	40	PLAC
	Region	702 – 779	78	Spacer
	Motif	199 – 206	8	Cysteine switch By similarity
	Compositional bias	60 – 120	61	Arg-rich
	Compositional bias	599 – 701	103	Cys-rich
Sites
	Active site	390	1	By similarity
	Metal binding	201	1	Zinc; in inhibited form By similarity
	Metal binding	389	1	Zinc; catalytic By similarity
	Metal binding	393	1	Zinc; catalytic By similarity
	Metal binding	399	1	Zinc; catalytic By similarity
Amino acid modifications
	Glycosylation	167	1	N-linked (GlcNAc...) Potential
	Glycosylation	483	1	N-linked (GlcNAc...) Potential
	Glycosylation	785	1	N-linked (GlcNAc...) Potential
	Glycosylation	790	1	N-linked (GlcNAc...) Potential
	Glycosylation	832	1	N-linked (GlcNAc...) Potential
	Glycosylation	839	1	N-linked (GlcNAc...) Potential
	Glycosylation	894	1	N-linked (GlcNAc...) Potential
	Disulfide bond	367 ↔ 447		By similarity
	Disulfide bond	406 ↔ 431		By similarity
	Disulfide bond	555 ↔ 592		By similarity
	Disulfide bond	559 ↔ 597		By similarity
	Disulfide bond	570 ↔ 582		By similarity
	Disulfide bond	873 ↔ 916		By similarity
	Disulfide bond	877 ↔ 921		By similarity
	Disulfide bond	888 ↔ 905		By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q8TE56-1 [UniParc]. Last modified June 1, 2002. Version 1. Checksum: A5C6540484754D5D	FASTA	1,095	121,100
	10 20 30 40 50 60 MCDGALLPPL VLPVLLLLVW GLDPGTAVGD AAADVEVVLP WRVRPDDVHL PPLPAAPGPR 70 80 90 100 110 120 RRRRPRTPPA APRARPGERA LLLHLPAFGR DLYLQLRRDL RFLSRGFEVE EAGAARRRGR 130 140 150 160 170 180 PAELCFYSGR VLGHPGSLVS LSACGAAGGL VGLIQLGQEQ VLIQPLNNSQ GPFSGREHLI 190 200 210 220 230 240 RRKWSLTPSP SAEAQRPEQL CKVLTEKKKP TWGRPSRDWR ERRNAIRLTS EHTVETLVVA 250 260 270 280 290 300 DADMVQYHGA EAAQRFILTV MNMVYNMFQH QSLGIKINIQ VTKLVLLRQR PAKLSIGHHG 310 320 330 340 350 360 ERSLESFCHW QNEEYGGARY LGNNQVPGGK DDPPLVDAAV FVTRTDFCVH KDEPCDTVGI 370 380 390 400 410 420 AYLGGVCSAK RKCVLAEDNG LNLAFTIAHE LGHNLGMNHD DDHSSCAGRS HIMSGEWVKG 430 440 450 460 470 480 RNPSDLSWSS CSRDDLENFL KSKVSTCLLV TDPRSQHTVR LPHKLPGMHY SANEQCQILF 490 500 510 520 530 540 GMNATFCRNM EHLMCAGLWC LVEGDTSCKT KLDPPLDGTE CGADKWCRAG ECVSKTPIPE 550 560 570 580 590 600 HVDGDWSPWG AWSMCSRTCG TGARFRQRKC DNPPPGPGGT HCPGASVEHA VCENLPCPKG 610 620 630 640 650 660 LPSFRDQQCQ AHDRLSPKKK GLLTAVVVDD KPCELYCSPL GKESPLLVAD RVLDGTPCGP 670 680 690 700 710 720 YETDLCVHGK CQKIGCDGII GSAAKEDRCG VCSGDGKTCH LVKGDFSHAR GTALKDSGKG 730 740 750 760 770 780 SINSDWKIEL PGEFQIAGTT VRYVRRGLWE KISAKGPTKL PLHLMVLLFH DQDYGIHYEY 790 800 810 820 830 840 TVPVNRTAEN QSEPEKPQDS LFIWTHSGWE GCSVQCGGGE RRTIVSCTRI VNKTTTLVND 850 860 870 880 890 900 SDCPQASRPE PQVRRCNLHP CQSRWVAGPW SPCSATCEKG FQHREVTCVY QLQNGTHVAT 910 920 930 940 950 960 RPLYCPGPRP AAVQSCEGQD CLSIWEASEW SQCSASCGKG VWKRTVACTN SQGKCDASTR 970 980 990 1000 1010 1020 PRAEEACEDY SGCYEWKTGD WSTCSSTCGK GLQSRVVQCM HKVTGRHGSE CPALSKPAPY 1030 1040 1050 1060 1070 1080 RQCYQEVCND RINANTITSP RLAALTYKCT RDQWTVYCRV IREKNLCQDM RWYQRCCQTC 1090 RDFYANKMRQ PPPSS

References

[1]

"Cloning, expression analysis, and structural characterization of seven novel human ADAMTSs, a family of metalloproteinases with disintegrin and thrombospondin-1 domains." Cal S., Obaya A.J., Llamazares M., Garabaya C., Quesada V., Lopez-Otin C. Gene 283:49-62(2002) [PubMed: 11867212] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AJ315735 mRNA. Translation: CAC86016.1.
RefSeq	NP_620688.2.
UniGene	Hs.513200 Hs.706371
3D structure databases
HSSP	HSSP built from PDB template 1LSL based on UniProtKB P07996.
ModBase	Search...
Protein family/group databases
MEROPS	M12.027.
Genome annotation databases
Ensembl	ENSG00000140470. Homo sapiens. [Contig view]
GeneID	170691.
KEGG	hsa:170691.
Organism-specific databases
H-InvDB	HIX0012615.
HGNC	HGNC:17109. ADAMTS17.
MIM	607511. gene.
PharmGKB	PA24543.
GenAtlas	Search...
GeneCards	Search...
Phylogenomic databases
HOGENOM	Q8TE56.
HOVERGEN	Q8TE56.
Gene expression databases
ArrayExpress	Q8TE56.
CleanEx	HS_ADAMTS17.
GermOnline	ENSG00000140470. Homo sapiens.
Family and domain databases
InterPro	IPR010294. ADAM_spacer1. IPR001762. Blood-coag_inhib_Disintegrin. IPR001818. Pept_M10A_M12B. IPR006025. Pept_M_Zn_BS. IPR001590. Peptidase_M12B. IPR013273. Peptidase_M12B_ADAM-TS. IPR002870. Peptidase_M12B_N. IPR010909. PLAC. IPR000884. TSP1. IPR008085. TSP_1. [Graphical view]
Pfam	PF05986. ADAM_spacer1. 1 hit. PF01562. Pep_M12B_propep. 1 hit. PF08686. PLAC. 1 hit. PF01421. Reprolysin. 1 hit. PF00090. TSP_1. 4 hits. [Graphical view]
PRINTS	PR01857. ADAMTSFAMILY. PR01705. TSP1REPEAT.
SMART	SM00209. TSP1. 5 hits. [Graphical view]
PROSITE	PS50215. ADAM_MEPRO. 1 hit. PS00546. CYSTEINE_SWITCH. False negative. PS00427. DISINTEGRIN_1. False negative. PS50214. DISINTEGRIN_2. False negative. PS50900. PLAC. 1 hit. PS50092. TSP1. 5 hits. PS00142. ZINC_PROTEASE. 1 hit. [Graphical view]
ProDom	Q8TE56. [Graphical view] [Entries sharing at least one domain]
BLOCKS	Search...
Other Resources
SOURCE	Search...
ProtoNet	Search...

Entry information

Entry name

ATS17_HUMAN

Accession

Primary (citable) accession number: Q8TE56

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 28, 2003
Last sequence update:	June 1, 2002
Last modified:	September 2, 2008
This is version 58 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)