Reviewed, UniProtKB/Swiss-Prot Q8WYA1 (BMAL2_HUMAN)

Names and origin

Protein names

Recommended name:
    Aryl hydrocarbon receptor nuclear translocator-like protein 2
Alternative name(s):
    Brain and muscle ARNT-like 2
    Member of PAS protein 9
    Basic-helix-loop-helix-PAS protein MOP9
    CYCLE-like factor
      Short name=CLIF

Gene names

Name:	ARNTL2
Synonyms:	BMAL2, CLIF, MOP9

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	636 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	ARNTL2-CLOCK heterodimers activate E-box element (3'-CACGTG-5') transcription. Also, in umbilical vein endothelial cells, activates SERPINE1 through E-box sites. This transactivation is inhibited by PER2 and CRY1.
Subunit structure	Component of the circadian core oscillator, which includes the CRY proteins, CLOCK, or NPAS2, ARNTL or ARNTL2, CSNK1D and/or CSNK1E, TIMELESS and the PER proteins. Interacts directly with CLOCK to form the ARNTL2-CLOCK transactivator. Can form heterodimers or homodimers which interact directly with CLOCK to form the transcription activator. Also interacts with NPAS2 and HIF1A.
Subcellular location	Nucleus.
Tissue specificity	Expressed in fetal brain. Highly expressed in brain and placenta. Lower levels in heart, liver, thymus, kidney and lung. Located to endothelial cells and neuronal cells of the suprachiasmatic nucleus (SCN). Also detected in endothelial cells of the heart, lung and kidney. In the brain, specifically expressed in the thalamus, hippocampus and amygdala.
Induction	Constitutively expressed. Has no circadian rhythm expression pattern.
Sequence similarities	Contains 1 basic helix-loop-helix (bHLH) domain. Contains 1 PAC (PAS-associated C-terminal) domain. Contains 2 PAS (PER-ARNT-SIM) domains.

Ontologies

Keywords
Biological process	Biological rhythms Transcription Transcription regulation
Cellular component	Nucleus
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Repeat
Ligand	DNA-binding
Molecular function	Activator
Gene Ontology (GO)
Biological process	entrainment of circadian clock Ref.2 Non-traceable author statement. Source: UniProtKB regulation of transcription, DNA-dependent Ref.2 Non-traceable author statement. Source: UniProtKB
Cellular component	nucleus Ref.2 Non-traceable author statement. Source: UniProtKB
Molecular function	transcription factor activity Ref.2 Non-traceable author statement. Source: UniProtKB
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
EPAS1	Q99814	2	EBI-1793513,EBI-447470

Alternative products

This entry describes 8 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q8WYA1-1)

Also known as: BMAL2a;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q8WYA1-2)

Also known as: BMAL2b;

The sequence of this isoform differs from the canonical sequence as follows:
     96-109: Missing.

Isoform 3 (identifier: Q8WYA1-3)

Also known as: BMAL2c;

The sequence of this isoform differs from the canonical sequence as follows:
     11-11: G → GEVAGGEATAPG
     62-95: Missing.
     96-109: Missing.

Isoform 4 (identifier: Q8WYA1-4)

Also known as: BMAL2d;

The sequence of this isoform differs from the canonical sequence as follows:
     62-95: Missing.
     96-109: Missing.

Isoform 5 (identifier: Q8WYA1-5)

Also known as: CLIF;

The sequence of this isoform differs from the canonical sequence as follows:
     62-95: Missing.

Isoform 6 (identifier: Q8WYA1-6)

The sequence of this isoform differs from the canonical sequence as follows:
     1-37: Missing.
     62-95: Missing.
     96-109: Missing.

Isoform 7 (identifier: Q8WYA1-7)

Also known as: MOP9 long form;

The sequence of this isoform differs from the canonical sequence as follows:
     1-37: Missing.
     96-109: Missing.

Isoform 8 (identifier: Q8WYA1-8)

Also known as: MOP9 short form;

The sequence of this isoform differs from the canonical sequence as follows:
     1-37: Missing.
     61-61: Q → H
     62-74: Missing.
     96-109: Missing.

Notes: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view
Molecule processing
	Chain	1 – 636	636	Aryl hydrocarbon receptor nuclear translocator-like protein 2
Regions
	Domain	121 – 161	41	Helix-loop-helix motif
	Domain	178 – 250	73	PAS 1
	Domain	357 – 427	71	PAS 2
	Domain	432 – 475	44	PAC
	DNA binding	108 – 120	13	Basic motif
Natural variations
	Alternative sequence	1 – 37	37	Missing in isoform 6, isoform 7 and isoform 8.
	Alternative sequence	11	1	G → GEVAGGEATAPG in isoform 3.
	Alternative sequence	61	1	Q → H in isoform 8.
	Alternative sequence	62 – 95	34	Missing in isoform 3, isoform 4, isoform 5 and isoform 6.
	Alternative sequence	62 – 74	13	Missing in isoform 8.
	Alternative sequence	96 – 109	14	Missing in isoform 2, isoform 3, isoform 4, isoform 6, isoform 7 and isoform 8.
	Natural variant	340	1	N → S: dbSNP rs1037921.
	Natural variant	574	1	A → V: dbSNP rs11049005.
Experimental info
	Sequence conflict	41	1	F → S Ref.1
	Sequence conflict	257	1	A → T Ref.3
	Sequence conflict	276	1	S → F Ref.3
	Sequence conflict	324	1	P → R Ref.1
	Sequence conflict	527	1	L → I Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (BMAL2a) [UniParc]. Last modified January 23, 2007. Version 2. Checksum: 972CE2BC5B05B1F3	FASTA	636	70,887
	10 20 30 40 50 60 MAAEEEAAAG GKVLREENQC IAPVVSSRVS PGTRPTAMGS FSSHMTEFPR KRKGSDSDPS 70 80 90 100 110 120 QSGIMTEKVV EKLSQNPLTY LLSTRIEISA SSGSRVEDGE HQVKMKAFRE AHSQTEKRRR 130 140 150 160 170 180 DKMNNLIEEL SAMIPQCNPM ARKLDKLTVL RMAVQHLRSL KGLTNSYVGS NYRPSFLQDN 190 200 210 220 230 240 ELRHLILKTA EGFLFVVGCE RGKILFVSKS VSKILNYDQA SLTGQSLFDF LHPKDVAKVK 250 260 270 280 290 300 EQLSSFDISP REKLIDAKTG LQVHSNLHAG RTRVYSGSRR SFFCRIKSCK ISVKEEHGCL 310 320 330 340 350 360 PNSKKKEHRK FYTIHCTGYL RSWPPNIVGM EEERNSKKDN SNFTCLVAIG RLQPYIVPQN 370 380 390 400 410 420 SGEINVKPTE FITRFAVNGK FVYVDQRATA ILGYLPQELL GTSCYEYFHQ DDHNNLTDKH 430 440 450 460 470 480 KAVLQSKEKI LTDSYKFRAK DGSFVTLKSQ WFSFTNPWTK ELEYIVSVNT LVLGHSEPGE 490 500 510 520 530 540 ASFLPCSSQS SEESSRQSCM SVPGMSTGTV LGAGSIGTDI ANEILDLQRL QSSSYLDDSS 550 560 570 580 590 600 PTGLMKDTHT VNCRSMSNKE LFPPSPSEMG ELEATRQNQS TVAVHSHEPL LSDGAQLDFD 610 620 630 ALCDNDDTAM AAFMNYLEAE GGLGDPGDFS DIQWTL
	Isoform 2 (BMAL2b) [UniParc]. Checksum: EE042DBFFB87BC63		622	69,231
	10 20 30 40 50 60 MAAEEEAAAG GKVLREENQC IAPVVSSRVS PGTRPTAMGS FSSHMTEFPR KRKGSDSDPS 70 80 90 100 110 120 QSGIMTEKVV EKLSQNPLTY LLSTRIEISA SSGSREAHSQ TEKRRRDKMN NLIEELSAMI 130 140 150 160 170 180 PQCNPMARKL DKLTVLRMAV QHLRSLKGLT NSYVGSNYRP SFLQDNELRH LILKTAEGFL 190 200 210 220 230 240 FVVGCERGKI LFVSKSVSKI LNYDQASLTG QSLFDFLHPK DVAKVKEQLS SFDISPREKL 250 260 270 280 290 300 IDAKTGLQVH SNLHAGRTRV YSGSRRSFFC RIKSCKISVK EEHGCLPNSK KKEHRKFYTI 310 320 330 340 350 360 HCTGYLRSWP PNIVGMEEER NSKKDNSNFT CLVAIGRLQP YIVPQNSGEI NVKPTEFITR 370 380 390 400 410 420 FAVNGKFVYV DQRATAILGY LPQELLGTSC YEYFHQDDHN NLTDKHKAVL QSKEKILTDS 430 440 450 460 470 480 YKFRAKDGSF VTLKSQWFSF TNPWTKELEY IVSVNTLVLG HSEPGEASFL PCSSQSSEES 490 500 510 520 530 540 SRQSCMSVPG MSTGTVLGAG SIGTDIANEI LDLQRLQSSS YLDDSSPTGL MKDTHTVNCR 550 560 570 580 590 600 SMSNKELFPP SPSEMGELEA TRQNQSTVAV HSHEPLLSDG AQLDFDALCD NDDTAMAAFM 610 620 NYLEAEGGLG DPGDFSDIQW TL
	Isoform 3 (BMAL2c) [UniParc]. Checksum: A5B1B84DBC4B5B40		599	66,493
	10 20 30 40 50 60 MAAEEEAAAG GEVAGGEATA PGKVLREENQ CIAPVVSSRV SPGTRPTAMG SFSSHMTEFP 70 80 90 100 110 120 RKRKGSDSDP SQEAHSQTEK RRRDKMNNLI EELSAMIPQC NPMARKLDKL TVLRMAVQHL 130 140 150 160 170 180 RSLKGLTNSY VGSNYRPSFL QDNELRHLIL KTAEGFLFVV GCERGKILFV SKSVSKILNY 190 200 210 220 230 240 DQASLTGQSL FDFLHPKDVA KVKEQLSSFD ISPREKLIDA KTGLQVHSNL HAGRTRVYSG 250 260 270 280 290 300 SRRSFFCRIK SCKISVKEEH GCLPNSKKKE HRKFYTIHCT GYLRSWPPNI VGMEEERNSK 310 320 330 340 350 360 KDNSNFTCLV AIGRLQPYIV PQNSGEINVK PTEFITRFAV NGKFVYVDQR ATAILGYLPQ 370 380 390 400 410 420 ELLGTSCYEY FHQDDHNNLT DKHKAVLQSK EKILTDSYKF RAKDGSFVTL KSQWFSFTNP 430 440 450 460 470 480 WTKELEYIVS VNTLVLGHSE PGEASFLPCS SQSSEESSRQ SCMSVPGMST GTVLGAGSIG 490 500 510 520 530 540 TDIANEILDL QRLQSSSYLD DSSPTGLMKD THTVNCRSMS NKELFPPSPS EMGELEATRQ 550 560 570 580 590 NQSTVAVHSH EPLLSDGAQL DFDALCDNDD TAMAAFMNYL EAEGGLGDPG DFSDIQWTL
	Isoform 4 (BMAL2d) [UniParc]. Checksum: 3D49ACC111064FD8		588	65,553
	10 20 30 40 50 60 MAAEEEAAAG GKVLREENQC IAPVVSSRVS PGTRPTAMGS FSSHMTEFPR KRKGSDSDPS 70 80 90 100 110 120 QEAHSQTEKR RRDKMNNLIE ELSAMIPQCN PMARKLDKLT VLRMAVQHLR SLKGLTNSYV 130 140 150 160 170 180 GSNYRPSFLQ DNELRHLILK TAEGFLFVVG CERGKILFVS KSVSKILNYD QASLTGQSLF 190 200 210 220 230 240 DFLHPKDVAK VKEQLSSFDI SPREKLIDAK TGLQVHSNLH AGRTRVYSGS RRSFFCRIKS 250 260 270 280 290 300 CKISVKEEHG CLPNSKKKEH RKFYTIHCTG YLRSWPPNIV GMEEERNSKK DNSNFTCLVA 310 320 330 340 350 360 IGRLQPYIVP QNSGEINVKP TEFITRFAVN GKFVYVDQRA TAILGYLPQE LLGTSCYEYF 370 380 390 400 410 420 HQDDHNNLTD KHKAVLQSKE KILTDSYKFR AKDGSFVTLK SQWFSFTNPW TKELEYIVSV 430 440 450 460 470 480 NTLVLGHSEP GEASFLPCSS QSSEESSRQS CMSVPGMSTG TVLGAGSIGT DIANEILDLQ 490 500 510 520 530 540 RLQSSSYLDD SSPTGLMKDT HTVNCRSMSN KELFPPSPSE MGELEATRQN QSTVAVHSHE 550 560 570 580 PLLSDGAQLD FDALCDNDDT AMAAFMNYLE AEGGLGDPGD FSDIQWTL
	Isoform 5 (CLIF) [UniParc]. Checksum: AD8937DD526D8B45		602	67,209
	10 20 30 40 50 60 MAAEEEAAAG GKVLREENQC IAPVVSSRVS PGTRPTAMGS FSSHMTEFPR KRKGSDSDPS 70 80 90 100 110 120 QVEDGEHQVK MKAFREAHSQ TEKRRRDKMN NLIEELSAMI PQCNPMARKL DKLTVLRMAV 130 140 150 160 170 180 QHLRSLKGLT NSYVGSNYRP SFLQDNELRH LILKTAEGFL FVVGCERGKI LFVSKSVSKI 190 200 210 220 230 240 LNYDQASLTG QSLFDFLHPK DVAKVKEQLS SFDISPREKL IDAKTGLQVH SNLHAGRTRV 250 260 270 280 290 300 YSGSRRSFFC RIKSCKISVK EEHGCLPNSK KKEHRKFYTI HCTGYLRSWP PNIVGMEEER 310 320 330 340 350 360 NSKKDNSNFT CLVAIGRLQP YIVPQNSGEI NVKPTEFITR FAVNGKFVYV DQRATAILGY 370 380 390 400 410 420 LPQELLGTSC YEYFHQDDHN NLTDKHKAVL QSKEKILTDS YKFRAKDGSF VTLKSQWFSF 430 440 450 460 470 480 TNPWTKELEY IVSVNTLVLG HSEPGEASFL PCSSQSSEES SRQSCMSVPG MSTGTVLGAG 490 500 510 520 530 540 SIGTDIANEI LDLQRLQSSS YLDDSSPTGL MKDTHTVNCR SMSNKELFPP SPSEMGELEA 550 560 570 580 590 600 TRQNQSTVAV HSHEPLLSDG AQLDFDALCD NDDTAMAAFM NYLEAEGGLG DPGDFSDIQW TL
	Isoform 6 [UniParc]. Checksum: F845E3F54FFA39B0		551	61,788
	10 20 30 40 50 60 MGSFSSHMTE FPRKRKGSDS DPSQEAHSQT EKRRRDKMNN LIEELSAMIP QCNPMARKLD 70 80 90 100 110 120 KLTVLRMAVQ HLRSLKGLTN SYVGSNYRPS FLQDNELRHL ILKTAEGFLF VVGCERGKIL 130 140 150 160 170 180 FVSKSVSKIL NYDQASLTGQ SLFDFLHPKD VAKVKEQLSS FDISPREKLI DAKTGLQVHS 190 200 210 220 230 240 NLHAGRTRVY SGSRRSFFCR IKSCKISVKE EHGCLPNSKK KEHRKFYTIH CTGYLRSWPP 250 260 270 280 290 300 NIVGMEEERN SKKDNSNFTC LVAIGRLQPY IVPQNSGEIN VKPTEFITRF AVNGKFVYVD 310 320 330 340 350 360 QRATAILGYL PQELLGTSCY EYFHQDDHNN LTDKHKAVLQ SKEKILTDSY KFRAKDGSFV 370 380 390 400 410 420 TLKSQWFSFT NPWTKELEYI VSVNTLVLGH SEPGEASFLP CSSQSSEESS RQSCMSVPGM 430 440 450 460 470 480 STGTVLGAGS IGTDIANEIL DLQRLQSSSY LDDSSPTGLM KDTHTVNCRS MSNKELFPPS 490 500 510 520 530 540 PSEMGELEAT RQNQSTVAVH SHEPLLSDGA QLDFDALCDN DDTAMAAFMN YLEAEGGLGD 550 PGDFSDIQWT L
	Isoform 7 (MOP9 long form) [UniParc]. Checksum: EE2E576065881B01		585	65,466
	10 20 30 40 50 60 MGSFSSHMTE FPRKRKGSDS DPSQSGIMTE KVVEKLSQNP LTYLLSTRIE ISASSGSREA 70 80 90 100 110 120 HSQTEKRRRD KMNNLIEELS AMIPQCNPMA RKLDKLTVLR MAVQHLRSLK GLTNSYVGSN 130 140 150 160 170 180 YRPSFLQDNE LRHLILKTAE GFLFVVGCER GKILFVSKSV SKILNYDQAS LTGQSLFDFL 190 200 210 220 230 240 HPKDVAKVKE QLSSFDISPR EKLIDAKTGL QVHSNLHAGR TRVYSGSRRS FFCRIKSCKI 250 260 270 280 290 300 SVKEEHGCLP NSKKKEHRKF YTIHCTGYLR SWPPNIVGME EERNSKKDNS NFTCLVAIGR 310 320 330 340 350 360 LQPYIVPQNS GEINVKPTEF ITRFAVNGKF VYVDQRATAI LGYLPQELLG TSCYEYFHQD 370 380 390 400 410 420 DHNNLTDKHK AVLQSKEKIL TDSYKFRAKD GSFVTLKSQW FSFTNPWTKE LEYIVSVNTL 430 440 450 460 470 480 VLGHSEPGEA SFLPCSSQSS EESSRQSCMS VPGMSTGTVL GAGSIGTDIA NEILDLQRLQ 490 500 510 520 530 540 SSSYLDDSSP TGLMKDTHTV NCRSMSNKEL FPPSPSEMGE LEATRQNQST VAVHSHEPLL 550 560 570 580 SDGAQLDFDA LCDNDDTAMA AFMNYLEAEG GLGDPGDFSD IQWTL
	Isoform 8 (MOP9 short form) [UniParc]. Checksum: FDDF781F6E2FDBC5		572	64,072
	10 20 30 40 50 60 MGSFSSHMTE FPRKRKGSDS DPSHQNPLTY LLSTRIEISA SSGSREAHSQ TEKRRRDKMN 70 80 90 100 110 120 NLIEELSAMI PQCNPMARKL DKLTVLRMAV QHLRSLKGLT NSYVGSNYRP SFLQDNELRH 130 140 150 160 170 180 LILKTAEGFL FVVGCERGKI LFVSKSVSKI LNYDQASLTG QSLFDFLHPK DVAKVKEQLS 190 200 210 220 230 240 SFDISPREKL IDAKTGLQVH SNLHAGRTRV YSGSRRSFFC RIKSCKISVK EEHGCLPNSK 250 260 270 280 290 300 KKEHRKFYTI HCTGYLRSWP PNIVGMEEER NSKKDNSNFT CLVAIGRLQP YIVPQNSGEI 310 320 330 340 350 360 NVKPTEFITR FAVNGKFVYV DQRATAILGY LPQELLGTSC YEYFHQDDHN NLTDKHKAVL 370 380 390 400 410 420 QSKEKILTDS YKFRAKDGSF VTLKSQWFSF TNPWTKELEY IVSVNTLVLG HSEPGEASFL 430 440 450 460 470 480 PCSSQSSEES SRQSCMSVPG MSTGTVLGAG SIGTDIANEI LDLQRLQSSS YLDDSSPTGL 490 500 510 520 530 540 MKDTHTVNCR SMSNKELFPP SPSEMGELEA TRQNQSTVAV HSHEPLLSDG AQLDFDALCD 550 560 570 NDDTAMAAFM NYLEAEGGLG DPGDFSDIQW TL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"cDNA cloning of a novel bHLH-PAS transcription factor superfamily gene, BMAL2; Its mRNA expression, subcellular distribution, and chromosomal localization." Ikeda M., Yu W., Hirai M., Ebisawa T., Honma S., Yoshimura K., Honma K., Nomura M. Biochem. Biophys. Res. Commun. 275:493-502(2000) [PubMed: 10964693] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 6), SUBCELLULAR LOCATION, TISSUE SPECIFICITY. Tissue: Brain.
[2]	"CLIF, a novel cycle-like factor, regulates the circadian oscillation of plasminogen activator inhibitor-1 gene expression." Maemura K., de La Monte S.M., Chin M.T., Layne M.D., Hsieh C.-M., Yet S.-F., Perrella M.A., Lee M.-E. J. Biol. Chem. 275:36847-36851(2000) [PubMed: 11018023] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 5), FUNCTION, INDUCTION, TISSUE SPECIFICITY, INTERACTION WITH CLOCK. Tissue: Umbilical vein endothelial cell.
[3]	"The basic helix-loop-helix-PAS protein MOP9 is a brain-specific heterodimeric partner of circadian and hypoxia factors." Hogenesch J.B., Gu Y.-Z., Moran S.M., Shimomura K., Radcliffe L.A., Takahashi J.S., Bradfield C.A. J. Neurosci. 20:RC83-RC83(2000) [PubMed: 10864977] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 7 AND 8), TISSUE SPECIFICITY, INTERACTION WITH CLOCK; NPAS2 AND HIF1A. Tissue: Brain.
[4]	"Chicken pineal clock genes: implication of BMAL2 as a bidirectional regulator in circadian clock oscillation." Okano T., Yamamoto K., Okano K., Hirota T., Kasahara T., Sasaki M., Takanaka Y., Fukada Y. Genes Cells 6:825-836(2001) [PubMed: 11554928] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2; 3 AND 4). Tissue: Embryonic kidney.
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3; 4 AND 5). Tissue: Placenta.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AB039921 mRNA. Translation: BAB01485.1. AF256215 mRNA. Translation: AAG34652.1. AF231338 mRNA. Translation: AAF71306.1. AF231339 mRNA. Translation: AAF71307.1. AF246960 mRNA. Translation: AAL50339.1. AF246961 mRNA. Translation: AAL50340.1. AF246962 mRNA. Translation: AAL50341.1. AF246963 mRNA. Translation: AAL50342.1. BC000172 mRNA. Translation: AAH00172.3. BC125061 mRNA. Translation: AAI25062.1. BC125062 mRNA. Translation: AAI25063.1.
RefSeq	NP_064568.3.
UniGene	Hs.434269 Hs.663740
3D structure databases
HSSP	HSSP built from PDB template 1AM9 based on UniProtKB P36956.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q8WYA1.
Genome annotation databases
Ensembl	ENSG00000029153. Homo sapiens. [Contig view]
GeneID	56938.
KEGG	hsa:56938.
Organism-specific databases
HGNC	HGNC:18984. ARNTL2.
PharmGKB	PA134896555.
GenAtlas	Search...
GeneCards	Search...
Phylogenomic databases
HOVERGEN	Q8WYA1.
Gene expression databases
ArrayExpress	Q8WYA1.
CleanEx	HS_ARNTL2.
Family and domain databases
InterPro	IPR001092. HLH_basic. IPR011598. HLH_DNA_bd. IPR001610. PAC. IPR000014. PAS. IPR000700. PAS-assoc_C. IPR013655. PAS_3. IPR013767. PAS_fold. [Graphical view]
Gene3D	G3DSA:4.10.280.10. HLH_DNA_bd. 1 hit.
Pfam	PF00010. HLH. 1 hit. PF00989. PAS. 1 hit. PF08447. PAS_3. 1 hit. [Graphical view]
SMART	SM00353. HLH. 1 hit. SM00086. PAC. 1 hit. SM00091. PAS. 2 hits. [Graphical view]
PROSITE	PS50888. HLH. 1 hit. PS50113. PAC. False negative. PS50112. PAS. 2 hits. [Graphical view]
ProDom	Q8WYA1. [Graphical view] [Entries sharing at least one domain]
BLOCKS	Search...
Other Resources
ProtoNet	Search...

Entry information

Entry name

BMAL2_HUMAN

Accession

Primary (citable) accession number: Q8WYA1
Secondary accession number(s): Q8WYA2 , Q8WYA3, Q8WYA4, Q96J63, Q9H2M4, Q9NS70, Q9NYQ4, Q9NYQ5

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 23, 2007
Last sequence update:	January 23, 2007
Last modified:	September 23, 2008
This is version 49 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)