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Reviewed, UniProtKB/Swiss-Prot Q91ZE9 (BMF_MOUSE)

Last modified November 4, 2008. Version 47. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Bcl-2-modifying factor
Gene names
Name: Bmf
OrganismMus musculus (Mouse)
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

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Protein attributes

Sequence length185 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

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General annotation (Comments)

Function

May play a role in apoptosis.

Subunit structure

Interacts with MCL1, BCL2, BCL2L1/BCL-Xl, BCL2A1 and BCL2L2/BCL-w. Interacts with the myosin V actin motor complex through its binding to DLC2.

Tissue specificity

Widely expressed with an abundant expression in pancreas, liver kidney and hematopoietic tissues.

Sequence similarities

Belongs to the Bcl-2 family.

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Ontologies

Keywords

   Biological processApoptosis
   Technical term3D-structure

Gene Ontology (GO)

   Biological processregulation of apoptosis Ref.1

Inferred from direct assay. Source: MGI

   Cellular componentcytoplasm Ref.1

Inferred from direct assay. Source: MGI

myosin complex Ref.1

Inferred from direct assay. Source: UniProtKB

   Molecular functionprotein binding Ref.1

Inferred from physical interaction. Source: UniProtKB

Complete GO annotation...

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Binary interactions

With

Entry

#Exp.

IntAct

Notes

BCL2P104152EBI-708032,EBI-77694From a different organism.
BCL2L1Q078171EBI-708032,EBI-78035From a different organism.
BCL2L1Q07817-11EBI-708032,EBI-287195From a different organism.
BCL2L2Q928432EBI-708032,EBI-707714From a different organism.
MCL1Q078201EBI-708032,EBI-1003422From a different organism.

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 185185Bcl-2-modifying factor
PRO_0000143112

Regions

Region67 – 759Interaction with DLC2
Motif134 – 14815BH3

Experimental info

Mutagenesis671D → A: Loss of interaction with DLC2
Mutagenesis681K → A: Loss of interaction with DLC2
Mutagenesis691A → P: Loss of interaction with DLC2
Mutagenesis1381L → A: Decrease in the interaction with BCL2 and BCL2L2

Secondary structure

1 ... 185
Helix Strand Turn

Details...

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Sequences

Sequence LengthMass (Da)Tools
Q91ZE9-1 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: DAE6EA080F3EA06B

FASTA18520,682
        10         20         30         40         50         60 
MEPPQCVEEL EDDVFQSEDG EPGTQPGGLL SADLFAQSQL DCPLSRLQLF PLTHCCGPGL 

        70         80         90        100        110        120 
RPISQEDKAT QTLSPASPSQ GVMLPCGVTE EPQRLFYGNA GYRLPLPASF PAGSPLGEQP 

       130        140        150        160        170        180 
PEGQFLQHRA EVQIARKLQC IADQFHRLHT QQHQQNRDRA WWQVFLFLQN LALNRQENRE 


GVGPW

« Hide

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References

« Hide 'large scale' references
[1]"Bmf: a proapoptotic BH3-only protein regulated by interaction with the myosin V actin motor complex, activated by anoikis."
Puthalakath H., Villunger A., O'Reilly L.A., Beaumont J.G., Coultas L., Cheney R.E., Huang D.C.S., Strasser A.
Science 293:1829-1832(2001) [PubMed: 11546872] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], INTERACTION WITH MCL1; BCL2; BCL2L1; BCL2L2 AND DLC2, MUTAGENESIS OF ASP-67; LYS-68 AND ALA-69.
Strain: C57BL/6J.
[2]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Heart and Thymus.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6.
Tissue: Brain.
[4]"Expression and transcriptional regulation of functionally distinct Bmf isoforms in B-chronic lymphocytic leukemia cells."
Morales A.A., Olsson A., Celsing F., Oesterborg A., Jondal M., Osorio L.M.
Leukemia 18:41-47(2004) [PubMed: 14574334] [Abstract]
Cited for: TISSUE SPECIFICITY.
[5]"Structural plasticity underpins promiscuous binding of the prosurvival protein A1."
Smits C., Czabotar P.E., Hinds M.G., Day C.L.
Structure 16:818-829(2008) [PubMed: 18462686] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS) OF 126-152 IN COMPLEX WITH BCL2A1.
+Additional computationally mapped references.

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Cross-references

Sequence databases

AY029253 mRNA. Translation: AAK38747.1.
AK084658 mRNA. Translation: BAC39243.1. Different initiation.
AK040622 mRNA. Translation: BAC30649.1.
BC079650 mRNA. Translation: AAH79650.1.
RefSeqNP_612186.2.
UniGeneMm.210125

3D structure databases

EntryMethodResolution (Å)ChainPositionsPDBsum
2VOGX-ray1.90B126-152[»]
ModBaseSearch...

Protein-protein interaction databases

IntActQ91ZE9.

Genome annotation databases

EnsemblENSMUSG00000040093. Mus musculus. [Contig view]
GeneID171543.
KEGGmmu:171543.

Organism-specific databases

MGIMGI:2176433. Bmf.

Phylogenomic databases

HOGENOMQ91ZE9.
HOVERGENQ91ZE9.

Gene expression databases

ArrayExpressQ91ZE9.
CleanExMM_BMF.
GermOnlineENSMUSG00000040093. Mus musculus.

Family and domain databases

InterProIPR002475. BCL2_apoptsis.
IPR000712. Bcl2_BH.
[Graphical view]
PROSITEPS50062. BCL2_FAMILY. False negative.
PS01259. BH3. False negative.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio371060.
SOURCESearch...

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Entry information

Entry nameBMF_MOUSE
AccessionPrimary (citable) accession number: Q91ZE9
Secondary accession number(s): Q8BUK0
Entry history
Integrated into UniProtKB/Swiss-Prot: December 21, 2004
Last sequence update: December 1, 2001
Last modified: November 4, 2008
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

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Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents