Acid extracellular protease precursor - Yarrowia lipolytica

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Reviewed, UniProtKB/Swiss-Prot Q92389 (AXP1_YARLI)

Last modified July 22, 2008. Version 50. History...

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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein names

Recommended name:
Acid extracellular protease
EC=3.4.23.-

Gene names

Name:	AXP1
Synonyms:	AXP
Ordered Locus Names:	YALI0B05654g

Organism

Yarrowia lipolytica (Candida lipolytica) [Complete proteome]

Taxonomic identifier

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Dipodascaceae › Yarrowia

Protein attributes

Sequence length	397 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology.

General annotation (Comments)

Subcellular location	Secreted.
Sequence similarities	Belongs to the peptidase A1 family.

Ontologies

Keywords
Cellular component	Secreted
Domain	Signal
Molecular function	Aspartyl protease Hydrolase Protease
PTM	Glycoprotein Zymogen
Technical term	Complete proteome
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Molecule processing

Signal peptide

17

Potential

Propeptide

18 – ?

Activation peptide Potential

Chain

? – 397

Acid extracellular protease

Sites

Active site

1

By similarity

Active site

1

By similarity

Amino acid modifications

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Disulfide bond

By similarity

Disulfide bond

By similarity

Sequences

Sequence

Length

Mass (Da)

Tools

Q92389-1 [UniParc].

Last modified February 1, 1997. Version 1.
Checksum: BD678814B4B8984F
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397

42,081

        10         20         30         40         50         60 
MQFSLATLTT LLAFVAAAPA NKGFVHAPIK KQSLQAAQSK IPNFASSGPI TAELYNELMA 

        70         80         90        100        110        120 
YQVQISLGGQ TISASIDTGS EILWVWENDS IACQVDQQDC DTDGSYNPKK SSTSKDTGVP 

       130        140        150        160        170        180 
FNINYGKGHA DGYLYTDNAV IGGASAPGFK FGVNSGDLSS GGFSMVFGIG VNSDASTSIS 

       190        200        210        220        230        240 
AQLQKSGEIS RNLYGMSFSD ANLAGTSNDN SEITFGAINT GRYTGSLKTI PRVATQGGYQ 

       250        260        270        280        290        300 
HFSVSASGKF GDVDLFDNDL VILDSGTTMT YLKSDYYNAF LGGLEDLDIT LSDYSGGWHG 

       310        320        330        340        350        360 
YPCSENSKIN FTYNFSGKEI TVTGHDLAIP GNAVNSNVDS SVCFMGVDDG GNMNLFGDTF 

       370        380        390 
LRAIYSVYDL ERDEVSIAQA AHGKPDNYVV ITGDVPN

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The extracellular acid protease gene of Yarrowia lipolytica: sequence and pH-regulated transcription." Young T.W., Wadeson A., Glover D.J., Quincey R.V., Butlin M.J., Kamei E.A. Microbiology 142:2913-2921(1996) [PubMed: 8885407] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: 148.
[2]	"Genome evolution in yeasts." Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I., de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L., Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S. Souciet J.-L. Nature 430:35-44(2004) [PubMed: 15229592] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: CLIB 122 / E 150.

Cross-references

Sequence databases
	X97068 Genomic DNA. Translation: CAA65778.1. CR382128 Genomic DNA. Translation: CAG82769.1.
RefSeq	XP_500538.1.
3D structure databases
HSSP	HSSP built from PDB template 1LYB based on UniProtKB P07339.
ModBase	Search...
Protein family/group databases
MEROPS	A01.036.
Genome annotation databases
GeneID	2907455.
KEGG	yli:YALI0B05654g.
Phylogenomic databases
HOGENOM	Q92389.
Family and domain databases
InterPro	IPR001969. Pept_Asp_AS. IPR009007. Pept_Aspartc_cat. IPR001461. Peptidase_A1. [Graphical view]
Gene3D	G3DSA:2.40.70.10. Pept_Aspartc_cat. 1 hit.
PANTHER	PTHR13683. Peptidase_A1. 1 hit.
Pfam	PF00026. Asp. 1 hit. [Graphical view]
PRINTS	PR00792. PEPSIN.
PROSITE	PS00141. ASP_PROTEASE. 1 hit. [Graphical view]
ProDom	Q92389. [Graphical view] [Entries sharing at least one domain]
BLOCKS	Search...
Other Resources
ProtoNet	Search...

Entry information

Entry name

AXP1_YARLI

Accession

Primary (citable) accession number: Q92389

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	February 1, 1997
Last modified:	July 22, 2008
This is version 50 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)

Relevant documents

Peptidase families

Classification of peptidase families and list of entries

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents