Tumor necrosis factor receptor superfamily member 14 precursor

Contribute

Send feedback

Reviewed, UniProtKB/Swiss-Prot Q92956 (TNR14_HUMAN)

Last modified July 22, 2008. Version 100. History...

Clusters with 100%, 90%, 50% identity |

Documents (7) |

Third-party data |

Customize display

text xml rdf/xml gff fasta

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Hide | Top

Names and origin

Protein names

Recommended name:
    Tumor necrosis factor receptor superfamily member 14
Alternative name(s):
    Herpesvirus entry mediator A
    Tumor necrosis factor receptor-like 2
      Short name=TR2

Gene names

Name:	TNFRSF14
Synonyms:	HVEA, HVEM
ORF Names:	UNQ329/PRO509

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Hide | Top

Protein attributes

Sequence length	283 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

Hide | Top

General annotation (Comments)

Function	Receptor for BTLA. Receptor for TNFSF14/LIGHT and homotrimeric TNFSF1/lymphotoxin-alpha. Involved in lymphocyte activation. Plays an important role in HSV pathogenesis because it enhanced the entry of several wild-type HSV strains of both serotypes into CHO cells, and mediated HSV entry into activated human T-cells.
Subunit structure	Interacts with TRAF2, TRAF3 and TRAF5.
Subcellular location	Membrane; Single-pass type I membrane proteinProbable.
Tissue specificity	Widely expressed, with the highest expression in lung, spleen and thymus.
Post-translational modification	N-glycosylated.
Sequence similarities	Contains 3 TNFR-Cys repeats.

Hide | Top

Ontologies

Keywords
Cellular component	Membrane
Coding sequence diversity	Polymorphism
Domain	Repeat Signal Transmembrane
Molecular function	Receptor
PTM	Glycoprotein
Technical term	3D-structure Direct protein sequencing
Gene Ontology (GO)
Biological process	cell surface receptor linked signal transduction Ref.10 Traceable author statement. Source: ProtInc immune response Ref.11 Traceable author statement. Source: ProtInc
Cellular component	integral to plasma membrane Ref.10 Inferred by curator. Source: ProtInc
Molecular function	tumor necrosis factor receptor activity Ref.10 Traceable author statement. Source: ProtInc
Complete GO annotation...

Hide | Top

Binary interactions

With	Entry	#Exp.	IntAct	Notes
GD	P57083	1	EBI-1056653,EBI-1031723	From a different organism.
LTA	P01374	1	EBI-1056653,EBI-524105
PDIA6	Q15084	1	EBI-1056653,EBI-1043087
SEC11A	P67812	1	EBI-1056653,EBI-1042500
TRAF1	Q13077	1	EBI-1056653,EBI-359224
TRAF2	Q12933-2	4	EBI-1056653,EBI-355760
TRAF3	Q13114	1	EBI-1056653,EBI-357631
TRAF5	O00463	4	EBI-1056653,EBI-523498
UGCGL1	Q53QP2	1	EBI-1056653,EBI-1056389

Hide | Top

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Molecule processing

Signal peptide

1 – 38

Chain

39 – 283

245

Tumor necrosis factor receptor superfamily member 14

Regions

Topological domain

39 – 202

164

Extracellular Potential

Transmembrane

203 – 223

Potential

Topological domain

224 – 283

Cytoplasmic Potential

Repeat

42 – 75

TNFR-Cys 1

Repeat

78 – 119

TNFR-Cys 2

Repeat

121 – 162

TNFR-Cys 3

Amino acid modifications

Glycosylation

110

N-linked (GlcNAc...)

Glycosylation

173

N-linked (GlcNAc...) Potential

Disulfide bond

Disulfide bond

Disulfide bond

Disulfide bond

Disulfide bond

Disulfide bond

Disulfide bond

Disulfide bond

Natural variations

Natural variant

K → R: dbSNP rs4870.

Natural variant

117

A → T: dbSNP rs2234163.

Natural variant

174

G → E: dbSNP rs11573986.

Natural variant

241

V → I: dbSNP rs2234167.

Secondary structure

283

Helix Strand Turn

Details...

Hide | Top

Sequences

Sequence

Length

Mass (Da)

Tools

Q92956-1 [UniParc].

Last modified April 27, 2001. Version 3.
Checksum: 46CE13C2C70242C1
Show »

FASTA

283

30,392

        10         20         30         40         50         60 
MEPPGDWGPP PWRSTPKTDV LRLVLYLTFL GAPCYAPALP SCKEDEYPVG SECCPKCSPG 

        70         80         90        100        110        120 
YRVKEACGEL TGTVCEPCPP GTYIAHLNGL SKCLQCQMCD PAMGLRASRN CSRTENAVCG 

       130        140        150        160        170        180 
CSPGHFCIVQ DGDHCAACRA YATSSPGQRV QKGGTESQDT LCQNCPPGTF SPNGTLEECQ 

       190        200        210        220        230        240 
HQTKCSWLVT KAGAGTSSSH WVWWFLSGSL VIVIVCSTVG LIICVKRRKP RGDVVKVIVS 

       250        260        270        280 
VQRKRQEAEG EATVIEALQA PPDVTTVAVE ETIPSFTGRS PNH

« Hide

Hide | Top

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Herpes simplex virus-1 entry into cells mediated by a novel member of the TNF/NGF receptor family." Montgomery R.I., Warner M.S., Lum B.J., Spear P.G. Cell 87:427-436(1996) [PubMed: 8898196] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Cervix adenocarcinoma.
[2]	"A newly identified member of the tumor necrosis factor receptor superfamily with a wide tissue distribution and involvement in lymphocyte activation." Kwon B.S., Tan K.B., Ni J., Oh K.-O., Lee Z.H., Kim K.K., Kim Y.-J., Wang S., Gentz R., Yu G.-L., Harrop J., Lyn S.D., Silverman C., Porter T.G., Truneh A., Young P.R. J. Biol. Chem. 272:14272-14276(1997) [PubMed: 9162061] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]	Zhang W., Wan T., Cao X. Submitted (MAY-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[4]	"Search for polymorphisms in the genes for herpesvirus entry mediator, Nectin-1, and Nectin-2 in immune seronegative individuals." Struyf F., Posavad C.M., Keyaerts E., Van Ranst M., Corey L., Spear P.G. J. Infect. Dis. 185:36-44(2002) [PubMed: 11756979] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANTS ARG-17 AND ILE-241.
[5]	"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. Gray A.M. Genome Res. 13:2265-2270(2003) [PubMed: 12975309] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ARG-17.
[6]	"NIEHS-SNPs, environmental genome project, NIEHS ES15478, Department of Genome Sciences, Seattle, WA (URL: http://egp.gs.washington.edu)." Livingston R.J., Rieder M.J., Chung M.-W., Ritchie T.K., Olson A.N., Nguyen C.P., Nguyen D.A., Poel C.L., Robertson P.D., Schackwitz W.S., Sherwood J.K., Sherwood A.M., Leithauser B.J., Nickerson D.A. Submitted (NOV-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS ARG-17; THR-117; GLU-174 AND ILE-241.
[7]	"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)." Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B. Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[8]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Skin.
[9]	"Signal peptide prediction based on analysis of experimentally verified cleavage sites." Zhang Z., Henzel W.J. Protein Sci. 13:2819-2824(2004) [PubMed: 15340161] [Abstract] Cited for: PROTEIN SEQUENCE OF 39-53.
[10]	"ATAR, a novel tumor necrosis factor receptor family member, signals through TRAF2 and TRAF5." Hsu H., Solovyev I., Colombero A., Elliott R., Kelley M., Boyle W.J. J. Biol. Chem. 272:13471-13474(1997) [PubMed: 9153189] [Abstract] Cited for: INTERACTION WITH TRAF2 AND TRAF5.
[11]	"Herpesvirus entry mediator, a member of the tumor necrosis factor receptor (TNFR) family, interacts with members of the TNFR-associated factor family and activates the transcription factors NF-kappaB and AP-1." Marsters S.A., Ayres T.M., Skubatch M., Gray C.L., Rothe M., Ashkenazi A. J. Biol. Chem. 272:14029-14032(1997) [PubMed: 9162022] [Abstract] Cited for: INTERACTION WITH TRAF3 AND TRAF5.
[12]	"Herpes simplex virus glycoprotein D bound to the human receptor HveA." Carfi A., Willis S.H., Whitbeck J.C., Krummenacher C., Cohen G.H., Eisenberg R.J., Wiley D.C. Mol. Cell 8:169-179(2001) [PubMed: 11511370] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.65 ANGSTROMS) OF 39-200 IN COMPLEX WITH HUMAN HERPESVIRUS 1 GLYCOPROTEIN.
[13]	"Attenuating lymphocyte activity: the crystal structure of the BTLA-HVEM complex." Compaan D.M., Gonzalez L.C., Tom I., Loyet K.M., Eaton D., Hymowitz S.G. J. Biol. Chem. 280:39553-39561(2005) [PubMed: 16169851] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF 26-137 IN COMPLEX WITH BTLA, GLYCOSYLATION AT ASN-110.
+	Additional computationally mapped references.

Hide | Top

Cross-references

Sequence databases

U70321 mRNA. Translation: AAB58354.1.
U81232 mRNA. Translation: AAD00505.1.
AF153978 mRNA. Translation: AAF75588.1.
AF373877 mRNA. Translation: AAL47717.1.
AF373878 mRNA. Translation: AAL47718.1.
AY358879 mRNA. Translation: AAQ89238.1.
AY466111 Genomic DNA. Translation: AAR23264.1.
CR456909 mRNA. Translation: CAG33190.1.
BC002794 mRNA. Translation: AAH02794.1.

RefSeq

NP_003811.2.

UniGene

Hs.512898

3D structure databases

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1JMA	X-ray	2.65	B	39-200	[»]
2AW2	X-ray	2.80	B/Y	39-142	[»]

ModBase

Search...

Protein-protein interaction databases

IntAct

Q92956.

Polymorphism databases

NIEHS-SNPs

Search...

Genome annotation databases

Ensembl

ENSG00000157873. Homo sapiens. [Contig view]

GeneID

8764.

KEGG

hsa:8764.

Organism-specific databases

H-InvDB

HIX0000059.

HGNC

HGNC:11912. TNFRSF14.

HPA

HPA006404.

MIM

602746. gene.

PharmGKB

PA36605.

GenAtlas

Search...

GeneCards

Search...

Phylogenomic databases

HOGENOM

Q92956.

HOVERGEN

Q92956.

Gene expression databases

ArrayExpress

Q92956.

CleanEx

HS_TNFRSF14.

GermOnline

ENSG00000157873. Homo sapiens.

Family and domain databases

InterPro

IPR008063. Fas_rcpt.
IPR001368. TNFR_c6.
[Graphical view]

Pfam

PF00020. TNFR_c6. 2 hits.
[Graphical view]

PRINTS

PR01680. FASRECEPTOR.

SMART

SM00208. TNFR. 3 hits.
[Graphical view]

PROSITE

PS00652. TNFR_NGFR_1. 1 hit.
PS50050. TNFR_NGFR_2. 2 hits.
[Graphical view]

ProDom

Q92956.
[Graphical view] [Entries sharing at least one domain]

BLOCKS

Search...

Other Resources

SOURCE

Search...

ProtoNet

Search...

Hide | Top

Entry information

Entry name

TNR14_HUMAN

Accession

Primary (citable) accession number: Q92956
Secondary accession number(s): Q6IB95

Q9UM65

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 27, 2001
Last sequence update:	April 27, 2001
Last modified:	July 22, 2008
This is version 100 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Hide | Top

Relevant documents

Human chromosome 1

Human chromosome 1: entries, gene names and cross-references to MIM

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

UniProtKB secondary accession numbers

Index of UniProtKB secondary accession numbers

SIMILARITY comments

Index of protein domains and families

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Keywords

Gene Ontology (GO)

Binary interactions

With

Entry

#Exp.

IntAct

Notes

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Natural variations

Secondary structure

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Polymorphism databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other Resources

Entry information

Relevant documents