Reviewed, UniProtKB/Swiss-Prot Q96A70 (ADC_HUMAN)

Names and origin

Protein names

Recommended name:
    Arginine decarboxylase
      Short name(s)=ARGDC, ADC
    EC=4.1.1.19
Alternative name(s):
    Ornithine decarboxylase-like protein
    ODC-paralogue
      Short name(s)=ODC-p

Gene names

Name:	ADC
Synonyms:	KIAA1945, ODCP

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	460 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Decarboxylates L-arginine to agmatine. Truncated splice isoforms probably lack activity.
Catalytic activity	L-arginine = agmatine + CO(2).
Cofactor	Pyridoxal phosphate By similarity.
Tissue specificity	Highly expressed in brain. Also expressed in testis.
Sequence similarities	Belongs to the Orn/Lys/Arg decarboxylase class-II family.

Ontologies

Keywords
Biological process	Polyamine biosynthesis
Coding sequence diversity	Alternative splicing
Ligand	Pyridoxal phosphate
Molecular function	Decarboxylase Lyase
Gene Ontology (GO)
Biological process	spermatogenesis Ref.1 Non-traceable author statement. Source: UniProtKB
Complete GO annotation...

Alternative products

This entry describes 5 isoforms produced by alternative splicing. [Align] [Select]

Notes: Additional isoforms seem to exist.

Isoform 1 (identifier: Q96A70-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q96A70-2)

The sequence of this isoform differs from the canonical sequence as follows:
     305-305: E → EAPLPPPHIATCAASEPSPPA

Isoform 3 (identifier: Q96A70-3)

The sequence of this isoform differs from the canonical sequence as follows:
     344-362: KPSTEQPLYSSSLWGPAVD → SKNHSPCYMSLESIHFIAV
     363-460: Missing.

Isoform 4 (identifier: Q96A70-4)

The sequence of this isoform differs from the canonical sequence as follows:
     151-151: K → KFVQQRGTACLIR
     344-362: KPSTEQPLYSSSLWGPAVD → SKNHSPCYMSLESIHFIAV
     363-460: Missing.

Isoform 6 (identifier: Q96A70-5)

The sequence of this isoform differs from the canonical sequence as follows:
     94-251: Missing.
     344-362: KPSTEQPLYSSSLWGPAVD → SKNHSPCYMSLESIHFIAV
     363-460: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view
Molecule processing
	Chain	1 – 460	460	Arginine decarboxylase
Sites
	Binding site	70	1	Pyridoxal phosphate (covalent) By similarity
Natural variations
	Alternative sequence	94 – 251	158	Missing in isoform 6.
	Alternative sequence	151	1	K → KFVQQRGTACLIR in isoform 4.
	Alternative sequence	305	1	E → EAPLPPPHIATCAASEPSPP A in isoform 2.
	Alternative sequence	344 – 362	19	KPSTE…GPAVD → SKNHSPCYMSLESIHFIAV in isoform 3, isoform 4 and isoform 6.
	Alternative sequence	363 – 460	98	Missing in isoform 3, isoform 4 and isoform 6.
Experimental info
	Sequence conflict	1 – 35	35	MAGYL…SQATT → QQGSSVASTEPGSGTWKDHG WHAQGASWMGSHIHPLLVIQ in BAB85531. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified December 1, 2001. Version 1. Checksum: 0E00667CA4BB0B56	FASTA	460	49,980
	10 20 30 40 50 60 MAGYLSESDF VMVEEGFSTR DLLKELTLGA SQATTDEVAA FFVADLGAIV RKHFCFLKCL 70 80 90 100 110 120 PRVRPFYAVK CNSSPGVLKV LAQLGLGFSC ANKAEMELVQ HIGIPASKII CANPCKQIAQ 130 140 150 160 170 180 IKYAAKHGIQ LLSFDNEMEL AKVVKSHPSA KMVLCIATDD SHSLSCLSLK FGVSLKSCRH 190 200 210 220 230 240 LLENAKKHHV EVVGVSFHIG SGCPDPQAYA QSIADARLVF EMGTELGHKM HVLDLGGGFP 250 260 270 280 290 300 GTEGAKVRFE EIASVINSAL DLYFPEGCGV DIFAELGRYY VTSAFTVAVS IIAKKEVLLD 310 320 330 340 350 360 QPGREEENGS TSKTIVYHLD EGVYGIFNSV LFDNICPTPI LQKKPSTEQP LYSSSLWGPA 370 380 390 400 410 420 VDGCDCVAEG LWLPQLHVGD WLVFDNMGAY TVGMGSPFWG TQACHITYAM SRVAWEALRR 430 440 450 460 QLMAAEQEDD VEGVCKPLSC GWEITDTLCV GPVFTPASIM
	Isoform 2 [UniParc]. Checksum: DA50F0600F2EC947		480	51,886
	10 20 30 40 50 60 MAGYLSESDF VMVEEGFSTR DLLKELTLGA SQATTDEVAA FFVADLGAIV RKHFCFLKCL 70 80 90 100 110 120 PRVRPFYAVK CNSSPGVLKV LAQLGLGFSC ANKAEMELVQ HIGIPASKII CANPCKQIAQ 130 140 150 160 170 180 IKYAAKHGIQ LLSFDNEMEL AKVVKSHPSA KMVLCIATDD SHSLSCLSLK FGVSLKSCRH 190 200 210 220 230 240 LLENAKKHHV EVVGVSFHIG SGCPDPQAYA QSIADARLVF EMGTELGHKM HVLDLGGGFP 250 260 270 280 290 300 GTEGAKVRFE EIASVINSAL DLYFPEGCGV DIFAELGRYY VTSAFTVAVS IIAKKEVLLD 310 320 330 340 350 360 QPGREAPLPP PHIATCAASE PSPPAEENGS TSKTIVYHLD EGVYGIFNSV LFDNICPTPI 370 380 390 400 410 420 LQKKPSTEQP LYSSSLWGPA VDGCDCVAEG LWLPQLHVGD WLVFDNMGAY TVGMGSPFWG 430 440 450 460 470 480 TQACHITYAM SRVAWEALRR QLMAAEQEDD VEGVCKPLSC GWEITDTLCV GPVFTPASIM
	Isoform 3 [UniParc]. Checksum: 39D276D8C9746B1C		362	39,357
	10 20 30 40 50 60 MAGYLSESDF VMVEEGFSTR DLLKELTLGA SQATTDEVAA FFVADLGAIV RKHFCFLKCL 70 80 90 100 110 120 PRVRPFYAVK CNSSPGVLKV LAQLGLGFSC ANKAEMELVQ HIGIPASKII CANPCKQIAQ 130 140 150 160 170 180 IKYAAKHGIQ LLSFDNEMEL AKVVKSHPSA KMVLCIATDD SHSLSCLSLK FGVSLKSCRH 190 200 210 220 230 240 LLENAKKHHV EVVGVSFHIG SGCPDPQAYA QSIADARLVF EMGTELGHKM HVLDLGGGFP 250 260 270 280 290 300 GTEGAKVRFE EIASVINSAL DLYFPEGCGV DIFAELGRYY VTSAFTVAVS IIAKKEVLLD 310 320 330 340 350 360 QPGREEENGS TSKTIVYHLD EGVYGIFNSV LFDNICPTPI LQKSKNHSPC YMSLESIHFI AV
	Isoform 4 [UniParc]. Checksum: 85EDB219B7463152		374	40,730
	10 20 30 40 50 60 MAGYLSESDF VMVEEGFSTR DLLKELTLGA SQATTDEVAA FFVADLGAIV RKHFCFLKCL 70 80 90 100 110 120 PRVRPFYAVK CNSSPGVLKV LAQLGLGFSC ANKAEMELVQ HIGIPASKII CANPCKQIAQ 130 140 150 160 170 180 IKYAAKHGIQ LLSFDNEMEL AKVVKSHPSA KFVQQRGTAC LIRMVLCIAT DDSHSLSCLS 190 200 210 220 230 240 LKFGVSLKSC RHLLENAKKH HVEVVGVSFH IGSGCPDPQA YAQSIADARL VFEMGTELGH 250 260 270 280 290 300 KMHVLDLGGG FPGTEGAKVR FEEIASVINS ALDLYFPEGC GVDIFAELGR YYVTSAFTVA 310 320 330 340 350 360 VSIIAKKEVL LDQPGREEEN GSTSKTIVYH LDEGVYGIFN SVLFDNICPT PILQKSKNHS 370 PCYMSLESIH FIAV
	Isoform 6 [UniParc]. Checksum: 2FB9097EBD4C9F69		204	22,300
	10 20 30 40 50 60 MAGYLSESDF VMVEEGFSTR DLLKELTLGA SQATTDEVAA FFVADLGAIV RKHFCFLKCL 70 80 90 100 110 120 PRVRPFYAVK CNSSPGVLKV LAQLGLGFSC ANKIASVINS ALDLYFPEGC GVDIFAELGR 130 140 150 160 170 180 YYVTSAFTVA VSIIAKKEVL LDQPGREEEN GSTSKTIVYH LDEGVYGIFN SVLFDNICPT 190 200 PILQKSKNHS PCYMSLESIH FIAV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Expression of a novel human ornithine decarboxylase-like protein in the central nervous system and testes." Pitkaenen L.T., Heiskala M., Andersson L.C. Biochem. Biophys. Res. Commun. 287:1051-1057(2001) [PubMed: 11587527] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2; 3; 4 AND 6), TISSUE SPECIFICITY.
[2]	"Expression of human arginine decarboxylase, the biosynthetic enzyme for agmatine." Zhu M.-Y., Iyo A., Piletz J.E., Regunathan S. Biochim. Biophys. Acta 1670:156-164(2004) [PubMed: 14738999] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, TISSUE SPECIFICITY.
[3]	"Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins." Nagase T., Kikuno R., Ohara O. DNA Res. 8:319-327(2001) [PubMed: 11853319] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Brain.
[4]	"The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R. Nature 441:315-321(2006) [PubMed: 16710414] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Brain.
[6]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 96-460 (ISOFORM 1). Tissue: Substantia nigra.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AY050634 mRNA. Translation: AAL08049.1. AY050635 mRNA. Translation: AAL08050.1. AY050636 mRNA. Translation: AAL08051.1. AY050637 mRNA. Translation: AAL08052.1. AY050638 mRNA. Translation: AAL08053.1. AY325129 mRNA. Translation: AAQ62560.1. AB075825 mRNA. Translation: BAB85531.1. AL020995 Genomic DNA. Translation: CAI19353.1. AL020995 Genomic DNA. Translation: CAI19354.1. AL020995 Genomic DNA. Translation: CAI19355.1. BC010449 mRNA. Translation: AAH10449.1. BC028128 mRNA. Translation: AAH28128.1. AK057051 mRNA. Translation: BAB71356.1. AK095127 mRNA. Translation: BAC04489.1.
RefSeq	NP_443724.1.
UniGene	Hs.101807
3D structure databases
HSSP	HSSP built from PDB template 7ODC based on UniProtKB P00860.
ModBase	Search...
Genome annotation databases
Ensembl	ENSG00000142920. Homo sapiens. [Contig view]
GeneID	113451.
KEGG	hsa:113451.
Organism-specific databases
H-InvDB	HIX0000388.
HGNC	HGNC:29957. ADC.
MIM	608353. gene.
PharmGKB	PA142672642.
HUGE	Search...
GenAtlas	Search...
GeneCards	Search...
GeneLynx	Search...
Phylogenomic databases
HOVERGEN	Q96A70.
Gene expression databases
ArrayExpress	Q96A70.
GermOnline	ENSG00000142920. Homo sapiens.
Family and domain databases
InterPro	IPR000183. De-COase2. IPR002433. Orn_de-COase. [Graphical view]
Pfam	PF02784. Orn_Arg_deC_N. 1 hit. PF00278. Orn_DAP_Arg_deC. 1 hit. [Graphical view]
PRINTS	PR01179. ODADCRBXLASE. PR01182. ORNDCRBXLASE.
PROSITE	PS00878. ODR_DC_2_1. 1 hit. PS00879. ODR_DC_2_2. 1 hit. [Graphical view]
ProDom	Q96A70. [Graphical view] [Entries sharing at least one domain]
BLOCKS	Search...
Other Resources
DrugBank	DB00125. L-Arginine. DB00114. Pyridoxal Phosphate.
SOURCE	Search...
ProtoNet	Search...

Entry information

Entry name

ADC_HUMAN

Accession

Primary (citable) accession number: Q96A70
Secondary accession number(s): Q5TIF4 , Q5TIF5, Q5TIF6, Q8TF56, Q96L54, Q96L55, Q96L56, Q96L57, Q96MD9

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 2002
Last sequence update:	December 1, 2001
Last modified:	July 22, 2008
This is version 61 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)