Reviewed, UniProtKB/Swiss-Prot Q96KE9 (BTBD6_HUMAN)

Names and origin

Protein names

Recommended name:
    BTB/POZ domain-containing protein 6
Alternative name(s):
    Lens BTB domain protein

Gene names

Name:	BTBD6
Synonyms:	BDPL

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	410 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Tissue specificity	Expressed in lens.
Sequence similarities	Contains 1 BTB (POZ) domain.

Ontologies

Keywords
Technical term	3D-structure
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view
Molecule processing
	Chain	1 – 410	410	BTB/POZ domain-containing protein 6
Regions
	Domain	8 – 78	71	BTB
Experimental info
	Sequence conflict	198	1	R → G in AAH42525. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Q96KE9-1 [UniParc]. Last modified November 28, 2003. Version 2. Checksum: 2EC0F14F0AE12769	FASTA	410	45,925
	10 20 30 40 50 60 MFNNELMADV HFVVGPPGAT RTVPAHKYVL AVGSSVFYAM FYGDLAEVKS EIHIPDVEPA 70 80 90 100 110 120 AFLILLKYMY SDEIDLEADT VLATLYAAKK YIVPALAKAC VNFLETSLEA KNACVLLSQS 130 140 150 160 170 180 RLFEEPELTQ RCWEVIDAQA EMALRSEGFC EIDRQTLEII VTREALNTKE AVVFEAVLNW 190 200 210 220 230 240 AEAECKRQGL PITPRNKRHV LGRALYLVRI PTMTLEEFAN GAAQSDILTL EETHSIFLWY 250 260 270 280 290 300 TATNKPRLDF PLTKRKGLAP QRCHRFQSSA YRSNQWRYRG RCDSIQFAVD RRVFIAGLGL 310 320 330 340 350 360 YGSSSGKAEY SVKIELKRLG VVLAQNLTKF MSDGSSNTFP VWFEHPVQVE QDTFYTASAV 370 380 390 400 410 LDGSELSYFG QEGMTEVQCG KVAFQFQCSS DSTNGTGVQG GQIPELIFYA

References

[1]	"Expressed sequence tag analysis of adult human lens for the NEIBank project: over 2000 non-redundant transcripts, novel genes and splice variants." Wistow G., Bernstein S.L., Wyatt M.K., Behal A., Touchman J.W., Bouffard G., Smith D., Peterson K. Mol. Vis. 8:171-184(2002) [PubMed: 12107413] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], TISSUE SPECIFICITY. Tissue: Lens.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Testis and Uterus.

Cross-references

Sequence databases

EMBLGenBankDDBJ

AF353674 mRNA. Translation: AAK39520.1. Different initiation.
BC006414 mRNA. Translation: AAH06414.1.
BC042525 mRNA. Translation: AAH42525.1.

RefSeq

NP_150374.1.

UniGene

Hs.7367

3D structure databases

PDBMSD

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2VKP	X-ray	1.90	A/B	1-108	[»]

ModBase

Search...

Genome annotation databases

Ensembl

ENSG00000184887. Homo sapiens. [Contig view]

GeneID

90135.

KEGG

hsa:90135.

Organism-specific databases

H-InvDB

HIX0026634.

HGNC

HGNC:19897. BTBD6.

PharmGKB

PA128394741.

GenAtlas

Search...

GeneCards

Search...

Phylogenomic databases

HOGENOM

Q96KE9.

HOVERGEN

Q96KE9.

Gene expression databases

ArrayExpress

Q96KE9.

CleanEx

HS_BTBD6.

GermOnline

ENSG00000184887. Homo sapiens.

Family and domain databases

InterPro

IPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR013069. BTB_POZ.
IPR013089. Kelch_related.
IPR012983. PHR.
[Graphical view]

Gene3D

G3DSA:3.30.710.10. BTB/POZ_fold. 1 hit.

PANTHER

PTHR23230. Kelch_related. 1 hit.

Pfam

PF00651. BTB. 1 hit.
PF08005. PHR. 1 hit.
[Graphical view]

SMART

SM00225. BTB. 1 hit.
[Graphical view]

PROSITE

PS50097. BTB. 1 hit.
[Graphical view]

ProDom

Q96KE9.
[Graphical view] [Entries sharing at least one domain]

BLOCKS

Search...

Other Resources

LinkHub

Q96KE9.

ProtoNet

Search...

Entry information

Entry name

BTBD6_HUMAN

Accession

Primary (citable) accession number: Q96KE9
Secondary accession number(s): Q8IVQ7, Q9BR94

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 28, 2003
Last sequence update:	November 28, 2003
Last modified:	July 22, 2008
This is version 46 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)