Reviewed, UniProtKB/Swiss-Prot Q96PN6 (ADCYA_HUMAN)

Names and origin

Protein names

Recommended name:
    Adenylate cyclase type 10
    EC=4.6.1.1
Alternative name(s):
    Adenylate cyclase homolog
    Testicular soluble adenylyl cyclase
    Germ cell soluble adenylyl cyclase
      Short name(s)=hsAC, sAC
    AH-related protein

Gene names

Name:	ADCY10
Synonyms:	SAC

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	1610 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Soluble adenylyl cyclase that has a critical role in mammalian spermatogenesis. Produces the cAMP which mediates in part the cAMP-responsive nuclear factors indispensable for maturation of sperm in the epididymis. Induces capacitation, the maturational process that sperm undergo prior to fertilization. May be the bicarbonate sensor. Involved in ciliary beat regulation.
Catalytic activity	ATP = 3',5'-cyclic AMP + diphosphate.
Cofactor	Binds 2 magnesium ions per subunit By similarity.
Enzyme regulation	Activated by manganese or magnesium ions. In the presence of magnesium ions, the enzyme is activated by bicarbonate while in the presence of manganese ions, the enzyme is inhibited by bicarbonate. In the absence of magnesium and bicarbonate, the enzyme is weakly activated by calcium.
Subcellular location	Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm › cytoskeleton. Cytoplasm › perinuclear region. Note= Distributed to subcellular compartments containing cAMP targets. Found as a plasma membrane-associated protein, protein concentrated in the perinuclear region and protein colocalized with actin or tubulin.
Tissue specificity	Weakly expressed in multiple tissues. Expressed in brain, heart, kidney, liver, lung, pancreas, peripheral blood leukocytes, placenta, skeletal muscle, stomach, thymus, airway epithelial cells, duodenum, jejunum and ileum. Very low level of expression in bone.
Post-translational modification	Cleavage may occur to generate the active 48 kDa form.
Involvement in disease	Genetic variations in ADCY10 are associated with absorptive hypercalciuria type 2 (HCA2) [MIM:143870]. Absorptive hypercalciuria (AH) is a common cause of calcium oxalate nephrolithiasis. Clinically, AH is characterized by intestinal hyperabsorption of calcium in the presence of normal serum calcium and immunoreactive PTH (iPTH). It is often accompanied by low bone mineral density (BMD), particularly of the lumbar spine. About 50% of patients with AH present with a family history of calcium oxalate nephrolithiasis and hypercalciuria.
Sequence similarities	Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. Contains 2 guanylate cyclase domains.
Biophysicochemical properties	Kinetic parameters: KM=0.8 mM for ATP-Mn(2+) KM=2.41 mM for Mg(2+)

Ontologies

Keywords
Biological process	cAMP biosynthesis
Cellular component	Cell membrane Cytoplasm Cytoskeleton Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Repeat
Ligand	ATP-binding Magnesium Metal-binding Nucleotide-binding
Molecular function	Lyase
PTM	Phosphoprotein
Gene Ontology (GO)
Cellular component	cytoplasm Traceable author statement. Source: ProtInc soluble fraction Traceable author statement. Source: ProtInc
Molecular function	adenylate cyclase activity Traceable author statement. Source: ProtInc
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q96PN6-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q96PN6-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-97: MNTPKEEFQD...IFGGDILKFA → MSLSE

Notes: No experimental confirmation available.

Isoform 3 (identifier: Q96PN6-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-1099: Missing.
     1100-1103: DNYM → MLFK
     1430-1471: YARLQEWDNF...GISRYMEGQV → ECEAGVGRRL...ELKIFCQEEP
     1472-1610: Missing.

Notes: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view
Molecule processing
	Chain	1 – 1610	1610	Adenylate cyclase type 10
Regions
	Domain	42 – 179	138	Guanylate cyclase 1
	Domain	293 – 418	126	Guanylate cyclase 2
Sites
	Metal binding	47	1	Magnesium 1 By similarity
	Metal binding	47	1	Magnesium 2 By similarity
	Metal binding	48	1	Magnesium 2 (via carbonyl oxygen) By similarity
	Metal binding	99	1	Magnesium 1 By similarity
	Metal binding	99	1	Magnesium 2 By similarity
Amino acid modifications
	Modified residue	809	1	Phosphothreonine
	Modified residue	810	1	Phosphoserine
Natural variations
	Alternative sequence	1 – 1099	1099	Missing in isoform 3.
	Alternative sequence	1 – 97	97	MNTPK…ILKFA → MSLSE in isoform 2.
	Alternative sequence	1100 – 1103	4	DNYM → MLFK in isoform 3.
	Alternative sequence	1430 – 1471	42	YARLQ…MEGQV → ECEAGVGRRLHTSRDPGMPD FRNGTTFTNFPIELKIFCQE EP in isoform 3.
	Alternative sequence	1472 – 1610	139	Missing in isoform 3.
	Natural variant	234	1	T → M: dbSNP rs16859886.
	Natural variant	697	1	V → I: dbSNP rs2071921.
Experimental info
	Sequence conflict	1359	1	L → P in AAK96045. Ref.4

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified February 5, 2008. Version 2. Checksum: B131F4BF1B03E304	FASTA	1,610	187,135
	10 20 30 40 50 60 MNTPKEEFQD WPIVRIAAHL PDLIVYGHFS PERPFMDYFD GVLMFVDISG FTAMTEKFSS 70 80 90 100 110 120 AMYMDRGAEQ LVEILNYHIS AIVEKVLIFG GDILKFAGDA LLALWRVERK QLKNIITVVI 130 140 150 160 170 180 KCSLEIHGLF ETQEWEEGLD IRVKIGLAAG HISMLVFGDE THSHFLVIGQ AVDDVRLAQN 190 200 210 220 230 240 MAQMNDVILS PNCWQLCDRS MIEIESVPDQ RAVKVNFLKP PPNFNFDEFF TKCTTFMHYY 250 260 270 280 290 300 PSGEHKNLLR LACTLKPDPE LEMSLQKYVM ESILKQIDNK QLQGYLSELR PVTIVFVNLM 310 320 330 340 350 360 FEDQDKAEEI GPAIQDAYMH ITSVLKIFQG QINKVFMFDK GCSFLCVFGF PGEKVPDELT 370 380 390 400 410 420 HALECAMDIF DFCSQVHKIQ TVSIGVASGI VFCGIVGHTV RHEYTVIGQK VNLAARMMMY 430 440 450 460 470 480 YPGIVTCDSV TYNGSNLPAY FFKELPKKVM KGVADSGPLY QYWGRTEKVM FGMACLICNR 490 500 510 520 530 540 KEDYPLLGRN KEINYFMYTM KKFLISNSSQ VLMYEGLPGY GKSQILMKIE YLAQGKNHRI 550 560 570 580 590 600 IAISLNKISF HQTFYTIQMF MANVLGLDTC KHYKERQTNL RNKVMTLLDE KFYCLLNDIF 610 620 630 640 650 660 HVQFPISREI SRMSTLKKQK QLEILFMKIL KLIVKEERII FIIDEAQFVD STSWRFMEKL 670 680 690 700 710 720 IRTLPIFIIM SLCPFVNIPC AAARAVIKNR NTTYIVVGAV QPNDISNKIC LDLNVSCISK 730 740 750 760 770 780 ELDSYLGEGS CGIPFYCEEL LKNLEHHEVL VFQQTESEEK TNRTWNNLFK YSIKLTEKLN 790 800 810 820 830 840 MVTLHSDKES EEVCHLTSGV RLKNLSPPTS LKEISLIQLD SMRLSHQMLV RCAAIIGLTF 850 860 870 880 890 900 TTELLFEILP CWNMKMMIKT LATLVESNIF YCFRNGKELQ KALKQNDPSF EVHYRSLSLK 910 920 930 940 950 960 PSEGMDHGEE EQLRELENEV IECHRIRFCN PMMQKTAYEL WLKDQRKAMH LKCARFLEED 970 980 990 1000 1010 1020 AHRCDHCRGR DFIPYHHFTV NIRLNALDMD AIKKMAMSHG FKTEEKLILS NSEIPETSAF 1030 1040 1050 1060 1070 1080 FPENRSPEEI REKILNFFDH VLTKMKTSDE DIIPLESCQC EEILEIVILP LAHHFLALGE 1090 1100 1110 1120 1130 1140 NDKALYYFLE IASAYLIFCD NYMAYMYLNE GQKLLKTLKK DKSWSQTFES ATFYSLKGEV 1150 1160 1170 1180 1190 1200 CFNMGQIVLA KKMLRKALKL LNRIFPYNLI SLFLHIHVEK NRHFHYVNRQ AQESPPPGKK 1210 1220 1230 1240 1250 1260 RLAQLYRQTV CLSLLWRIYS YSYLFHCKYY AHLAVMMQMN TALETQNCFQ IIKAYLDYSL 1270 1280 1290 1300 1310 1320 YHHLAGYKGV WFKYEVMAME HIFNLPLKGE GIEIVAYVAE TLVFNKLIMG HLDLAIELGS 1330 1340 1350 1360 1370 1380 RALQMWALLQ NPNRHYQSLC RLSRCLLLNS RYPQLIQVLG RLWELSVTQE HIFSKAFFYF 1390 1400 1410 1420 1430 1440 VCLDILLYSG FVYRTFEECL EFIHQYENNR ILKFHSGLLL GLYSSVAIWY ARLQEWDNFY 1450 1460 1470 1480 1490 1500 KFSNRAKNLL PRRTMTLTYY DGISRYMEGQ VLHLQKQIKE QSENAQASGE ELLKNLENLV 1510 1520 1530 1540 1550 1560 AQNTTGPVFC PRLYHLMAYV CILMGDGQKC GLFLNTALRL SETQGNILEK CWLNMNKESW 1570 1580 1590 1600 1610 YSTSELKEDQ WLQTILSLPS WEKIVAGRVN IQDLQKNKFL MRANTVDNHF
	Isoform 2 [UniParc]. Checksum: F4E0238C2AA6B39A		1,518	176,577
	10 20 30 40 50 60 MSLSEGDALL ALWRVERKQL KNIITVVIKC SLEIHGLFET QEWEEGLDIR VKIGLAAGHI 70 80 90 100 110 120 SMLVFGDETH SHFLVIGQAV DDVRLAQNMA QMNDVILSPN CWQLCDRSMI EIESVPDQRA 130 140 150 160 170 180 VKVNFLKPPP NFNFDEFFTK CTTFMHYYPS GEHKNLLRLA CTLKPDPELE MSLQKYVMES 190 200 210 220 230 240 ILKQIDNKQL QGYLSELRPV TIVFVNLMFE DQDKAEEIGP AIQDAYMHIT SVLKIFQGQI 250 260 270 280 290 300 NKVFMFDKGC SFLCVFGFPG EKVPDELTHA LECAMDIFDF CSQVHKIQTV SIGVASGIVF 310 320 330 340 350 360 CGIVGHTVRH EYTVIGQKVN LAARMMMYYP GIVTCDSVTY NGSNLPAYFF KELPKKVMKG 370 380 390 400 410 420 VADSGPLYQY WGRTEKVMFG MACLICNRKE DYPLLGRNKE INYFMYTMKK FLISNSSQVL 430 440 450 460 470 480 MYEGLPGYGK SQILMKIEYL AQGKNHRIIA ISLNKISFHQ TFYTIQMFMA NVLGLDTCKH 490 500 510 520 530 540 YKERQTNLRN KVMTLLDEKF YCLLNDIFHV QFPISREISR MSTLKKQKQL EILFMKILKL 550 560 570 580 590 600 IVKEERIIFI IDEAQFVDST SWRFMEKLIR TLPIFIIMSL CPFVNIPCAA ARAVIKNRNT 610 620 630 640 650 660 TYIVVGAVQP NDISNKICLD LNVSCISKEL DSYLGEGSCG IPFYCEELLK NLEHHEVLVF 670 680 690 700 710 720 QQTESEEKTN RTWNNLFKYS IKLTEKLNMV TLHSDKESEE VCHLTSGVRL KNLSPPTSLK 730 740 750 760 770 780 EISLIQLDSM RLSHQMLVRC AAIIGLTFTT ELLFEILPCW NMKMMIKTLA TLVESNIFYC 790 800 810 820 830 840 FRNGKELQKA LKQNDPSFEV HYRSLSLKPS EGMDHGEEEQ LRELENEVIE CHRIRFCNPM 850 860 870 880 890 900 MQKTAYELWL KDQRKAMHLK CARFLEEDAH RCDHCRGRDF IPYHHFTVNI RLNALDMDAI 910 920 930 940 950 960 KKMAMSHGFK TEEKLILSNS EIPETSAFFP ENRSPEEIRE KILNFFDHVL TKMKTSDEDI 970 980 990 1000 1010 1020 IPLESCQCEE ILEIVILPLA HHFLALGEND KALYYFLEIA SAYLIFCDNY MAYMYLNEGQ 1030 1040 1050 1060 1070 1080 KLLKTLKKDK SWSQTFESAT FYSLKGEVCF NMGQIVLAKK MLRKALKLLN RIFPYNLISL 1090 1100 1110 1120 1130 1140 FLHIHVEKNR HFHYVNRQAQ ESPPPGKKRL AQLYRQTVCL SLLWRIYSYS YLFHCKYYAH 1150 1160 1170 1180 1190 1200 LAVMMQMNTA LETQNCFQII KAYLDYSLYH HLAGYKGVWF KYEVMAMEHI FNLPLKGEGI 1210 1220 1230 1240 1250 1260 EIVAYVAETL VFNKLIMGHL DLAIELGSRA LQMWALLQNP NRHYQSLCRL SRCLLLNSRY 1270 1280 1290 1300 1310 1320 PQLIQVLGRL WELSVTQEHI FSKAFFYFVC LDILLYSGFV YRTFEECLEF IHQYENNRIL 1330 1340 1350 1360 1370 1380 KFHSGLLLGL YSSVAIWYAR LQEWDNFYKF SNRAKNLLPR RTMTLTYYDG ISRYMEGQVL 1390 1400 1410 1420 1430 1440 HLQKQIKEQS ENAQASGEEL LKNLENLVAQ NTTGPVFCPR LYHLMAYVCI LMGDGQKCGL 1450 1460 1470 1480 1490 1500 FLNTALRLSE TQGNILEKCW LNMNKESWYS TSELKEDQWL QTILSLPSWE KIVAGRVNIQ 1510 DLQKNKFLMR ANTVDNHF
	Isoform 3 [UniParc]. Checksum: E645DCFBE8E415A6		372	43,900
	10 20 30 40 50 60 MLFKAYMYLN EGQKLLKTLK KDKSWSQTFE SATFYSLKGE VCFNMGQIVL AKKMLRKALK 70 80 90 100 110 120 LLNRIFPYNL ISLFLHIHVE KNRHFHYVNR QAQESPPPGK KRLAQLYRQT VCLSLLWRIY 130 140 150 160 170 180 SYSYLFHCKY YAHLAVMMQM NTALETQNCF QIIKAYLDYS LYHHLAGYKG VWFKYEVMAM 190 200 210 220 230 240 EHIFNLPLKG EGIEIVAYVA ETLVFNKLIM GHLDLAIELG SRALQMWALL QNPNRHYQSL 250 260 270 280 290 300 CRLSRCLLLN SRYPQLIQVL GRLWELSVTQ EHIFSKAFFY FVCLDILLYS GFVYRTFEEC 310 320 330 340 350 360 LEFIHQYENN RILKFHSGLL LGLYSSVAIW ECEAGVGRRL HTSRDPGMPD FRNGTTFTNF 370 PIELKIFCQE EP

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification and functional analysis of splice variants of the germ cell soluble adenylyl cyclase." Jaiswal B.S., Conti M. J. Biol. Chem. 276:31698-31708(2001) [PubMed: 11423534] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[2]	"Identification and characterization of a gene with base substitutions associated with the absorptive hypercalciuria phenotype and low spinal bone density." Reed B.Y., Gitomer W.L., Heller H.J., Hsu M.C., Lemke M., Padalino P., Pak C.Y.C. J. Clin. Endocrinol. Metab. 87:1476-1485(2002) [PubMed: 11932268] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), TISSUE SPECIFICITY, INVOLVEMENT IN HCA2. Tissue: Intestine.
[3]	"Kinetic properties of 'soluble' adenylyl cyclase. Synergism between calcium and bicarbonate." Litvin T.N., Kamenetsky M., Zarifyan A., Buck J., Levin L.R. J. Biol. Chem. 278:15922-15926(2003) [PubMed: 12609998] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), BIOPHYSICOCHEMICAL PROPERTIES.
[4]	"Cloning of a human testicular soluble adenylyl cyclase." Khole V.V., Westbrook V.A., Mandal A., Herr J.C., Visconti P.E. Submitted (AUG-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT ILE-697.
[5]	Rhodes S. Submitted (JAN-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
[6]	"The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R. Nature 441:315-321(2006) [PubMed: 16710414] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT ILE-697.
[7]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT ILE-697.
[8]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ILE-697.
[9]	"Compartmentalization of bicarbonate-sensitive adenylyl cyclase in distinct signaling microdomains." Zippin J.H., Chen Y., Nahirney P., Kamenetsky M., Wuttke M.S., Fischman D.A., Levin L.R., Buck J. FASEB J. 17:82-84(2003) [PubMed: 12475901] [Abstract] Cited for: SUBCELLULAR LOCATION.
[10]	"Cloning and characterization of the human soluble adenylyl cyclase." Geng W., Wang Z., Zhang J., Reed B.Y., Pak C.Y.C., Moe O.W. Am. J. Physiol. 288:C1305-C1316(2005) [PubMed: 15659711] [Abstract] Cited for: TISSUE SPECIFICITY, ENZYME REGULATION, SUBCELLULAR LOCATION, FUNCTION.
[11]	"Soluble adenylyl cyclase is localized to cilia and contributes to ciliary beat frequency regulation via production of cAMP." Schmid A., Sutto Z., Nlend M.-C., Horvath G., Schmid N., Buck J., Levin L.R., Conner G.E., Fregien N., Salathe M. J. Gen. Physiol. 130:99-109(2007) [PubMed: 17591988] [Abstract] Cited for: FUNCTION, TISSUE SPECIFICITY.
[12]	"Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra." Yu L.-R., Zhu Z., Chan K.C., Issaq H.J., Dimitrov D.S., Veenstra T.D. J. Proteome Res. 6:4150-4162(2007) [PubMed: 17924679] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-809 AND SER-810, MASS SPECTROMETRY. Tissue: Epithelium.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF271058 mRNA. Translation: AAF74296.1. AF331033 mRNA. Translation: AAL57036.1. AF176813 mRNA. Translation: AAF65931.1. AF299350 mRNA. Translation: AAK96045.1. AL035122 mRNA. Translation: CAA22684.1. Z97876, Z99943 Genomic DNA. Translation: CAI20073.1. Z97876, Z99943 Genomic DNA. Translation: CAI20074.1. Z99943, Z97876 Genomic DNA. Translation: CAI20146.1. Z99943, Z97876 Genomic DNA. Translation: CAI20147.1. CH471067 Genomic DNA. Translation: EAW90804.1. CH471067 Genomic DNA. Translation: EAW90807.1. BC117366 mRNA. Translation: AAI17367.1. BC117372 mRNA. Translation: AAI17373.1.
RefSeq	NP_060887.1.
UniGene	Hs.320892
3D structure databases
ModBase	Search...
Genome annotation databases
Ensembl	ENSG00000143199. Homo sapiens. [Contig view]
GeneID	55811.
KEGG	hsa:55811.
Organism-specific databases
HGNC	HGNC:21285. ADCY10.
MIM	143870. phenotype. 605205. gene.
GenAtlas	Search...
GeneCards	Search...
GeneLynx	Search...
Phylogenomic databases
HOVERGEN	Q96PN6.
Gene expression databases
ArrayExpress	Q96PN6.
CleanEx	HS_ADCY10.
Family and domain databases
InterPro	IPR001054. A/G_cyclase. IPR016577. Adenylate_cylcase_typ10. [Graphical view]
Gene3D	G3DSA:3.30.70.1230. A/G_cyclase. 2 hits.
Pfam	PF00211. Guanylate_cyc. 2 hits. [Graphical view]
PIRSF	PIRSF011131. Soluble_adenylyl_cyclase. 1 hit.
SMART	SM00044. CYCc. 1 hit. [Graphical view]
PROSITE	PS00452. GUANYLATE_CYCLASE_1. False negative. PS50125. GUANYLATE_CYCLASE_2. 2 hits. [Graphical view]
ProDom	Q96PN6. [Graphical view] [Entries sharing at least one domain]
BLOCKS	Search...
Other Resources
SOURCE	Search...
ProtoNet	Search...

Entry information

Entry name

ADCYA_HUMAN

Accession

Primary (citable) accession number: Q96PN6
Secondary accession number(s): O95558 , Q5R329, Q5R330, Q8WXV4, Q9NNX0

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	February 5, 2008
Last modified:	July 22, 2008
This is version 43 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)