Unreviewed, UniProtKB/TrEMBL Q98009 (Q98009_9PARA)

Names and origin

Protein names	Recommended name:     Hemagglutinin-neuraminidase RuleBase RU003717V0     EC=3.2.1.18
Organism	Human parainfluenza virus 1 EMBL AAB17174.1
Taxonomic identifier	12730 [NCBI]
Taxonomic lineage	Viruses › ssRNA negative-strand viruses › Mononegavirales › Paramyxoviridae › Paramyxovirinae › Respirovirus

Protein attributes

Sequence length	575 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Attaches the virus to sialic acid-containing cell receptors and thereby initiating infection. Binding of HN protein to the receptor induces a conformational change that allows the F protein to trigger virion/cell membranes fusion By similarity. RuleBase RU003717V0 Neuraminidase activity ensures the efficient spread of the virus by dissociating the mature virions from the neuraminic acid containing glycoproteins By similarity. RuleBase RU003717V0
Catalytic activity	Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates. RuleBase RU003717V0
Sequence similarities	Belongs to the paramyxoviruses hemagglutinin-neuraminidase family. RuleBase RU004216V0

Ontologies

Keywords
Cellular component	Envelope protein RuleBase RU004216V0 Spearmint SPM000665 Membrane Virion
Domain	Transmembrane Spearmint SPM000665 RuleBase RU003717V0
Molecular function	Hemagglutinin RuleBase RU004216V0 Spearmint SPM000665 Hydrolase RuleBase RU003717V0
Gene Ontology (GO)
Biological process	viral infectious cycle Inferred from electronic annotation. Source: InterPro
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW viral envelope Inferred from electronic annotation. Source: InterPro
Molecular function	exo-alpha-sialidase activity Inferred from electronic annotation. Source: InterPro host cell surface receptor binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q98009-1 [UniParc]. Last modified February 1, 1997. Version 1. Checksum: E775981F6095FCCA	FASTA	575	63,651
	10 20 30 40 50 60 MAEKGKINSS YWSTTRNDNS TVNTHINTPA GRTHIWLLIA TTMHTVLSFI IMILCIDLII 70 80 90 100 110 120 KQDTCMKTNI MTVSSVNESA KTIKETITEL MRQEVISRTI NIQSSVQSGI PILLNKQSRD 130 140 150 160 170 180 LTQLIEKSCN RQELAQICEN TIAIHHADGI SPLDPHDFWR CPVGEPLLSN NPNISLLPGP 190 200 210 220 230 240 SLLSGSTTIS GCVRLPSLSI GDAIYAYSSN LITQGCADIG KSYQVLQLGY ISLNSDMYPD 250 260 270 280 290 300 LNPVISHTYD INDNRISCSV IAAGTRGYQL CSLPTVNETT DYSSRGIGDL VFDILDLKGK 310 320 330 340 350 360 TKSQRYKNED ITFDHPFSAM YPSVGSGIKI ENTLIFLGYG GLTTPLQGNT KCVINKCANV 370 380 390 400 410 420 NQSVCNDALK ITWLKKRQVV NVLIRINNYL SDRPKIVVET IPITQNYLGA EGRLLKLGKK 430 440 450 460 470 480 IYIYTRSSGW HSNLQIGSLD INNPITINWA PHKVLSRPGN PDCNWFNKCP RECISGVYTD 490 500 510 520 530 540 AYPLSPDAVN VATTTLYANT SRVNPTIMYS STSKIINMLR LKNGQLEAAY TTTSCITHFG 550 560 570 KGYCFHIVEI NQTSLNTLQP MLFKTSIPKI CKVTS

References

[1]	"Two distinct human parainfluenza virus type 1 genotypes detected during the 1991 Milwaukee epidemic." Henrickson K.J., Savatski L.L. J. Clin. Microbiol. 34:695-700(1996) [PubMed: 8904440] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.

Cross-references

Sequence databases
EMBLGenBankDDBJ	U70939 Genomic RNA. Translation: AAB17174.1.
3D structure databases
ModBase	Search...
Family and domain databases
InterPro	IPR000665. Hemagglutn-neuramid_glycoprot. IPR016285. Hemagglutn-neuramid_paramyxo. [Graphical view]
Pfam	PF00423. HN. 1 hit. [Graphical view]
PIRSF	PIRSF001072. Hemagglut-neuramid_paramyxoV. 1 hit.

Entry information

Entry name

Q98009_9PARA

Accession

Primary (citable) accession number: Q98009

Entry history

Integrated into UniProtKB/TrEMBL:	February 1, 1997
Last sequence update:	February 1, 1997
Last modified:	July 22, 2008
This is version 44 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)