Reviewed, UniProtKB/Swiss-Prot Q98907 (P2RY3_CHICK)

Names and origin

Protein names

Recommended name:
    P2Y purinoceptor 3
      Short name=P2Y3
Alternative name(s):
    Nucleoside diphosphate receptor

Gene names

Name:

P2RY3

Organism

Gallus gallus (Chicken)

Taxonomic identifier

9031 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galliformes › Phasianidae › Phasianinae › Gallus

Protein attributes

Sequence length	328 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Receptor for extracellular ADP > UTP > ATP = UDP. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Domain	Transmembrane
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Glycoprotein
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view
Molecule processing
	Chain	1 – 328	328	P2Y purinoceptor 3
Regions
	Topological domain	1 – 22	22	Extracellular Potential
	Transmembrane	23 – 43	21	1 Potential
	Topological domain	44 – 57	14	Cytoplasmic Potential
	Transmembrane	58 – 78	21	2 Potential
	Topological domain	79 – 96	18	Extracellular Potential
	Transmembrane	97 – 117	21	3 Potential
	Topological domain	118 – 139	22	Cytoplasmic Potential
	Transmembrane	140 – 160	21	4 Potential
	Topological domain	161 – 189	29	Extracellular Potential
	Transmembrane	190 – 210	21	5 Potential
	Topological domain	211 – 231	21	Cytoplasmic Potential
	Transmembrane	232 – 252	21	6 Potential
	Topological domain	253 – 275	23	Extracellular Potential
	Transmembrane	276 – 298	23	7 Potential
	Topological domain	299 – 323	25	Extracellular Potential
Amino acid modifications
	Glycosylation	5	1	N-linked (GlcNAc...) Potential
	Disulfide bond	94 ↔ 172		By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q98907-1 [UniParc]. Last modified February 1, 1997. Version 1. Checksum: 7A3BF1C91F54FAAB	FASTA	328	37,587
	10 20 30 40 50 60 MSMANFTGGR NSCTFHEEFK QVLLPLVYSV VFLLGLPLNA VVIGQIWLAR KALTRTTIYM 70 80 90 100 110 120 LNLAMADLLY VCSLPLLIYN YTQKDYWPFG DFTCKFVRFQ FYTNLHGSIL FLTCISVQRY 130 140 150 160 170 180 MGICHPLASW HKKKGKKLTW LVCAAVWFIV IAQCLPTFVF ASTGTQRNRT VCYDLSPPDR 190 200 210 220 230 240 STSYFPYGIT LTITGFLLPF AAILACYCSM ARILCQKDEL IGLAVHKKKD KAVRMIIIVV 250 260 270 280 290 300 IVFSISFFPF HLTKTIYLIV RSSASLPCPT LQAFAIAYKC TRPFASMNSV LDPILFYFTQ 310 320 RKFRESTRYL LDKMSSKWRQ DHCISYGS

References

[1]

"A novel G protein-coupled P2 purinoceptor (P2Y3) activated preferentially by nucleoside diphosphates." Webb T.E., Henderson D., King B.F., Wang S., Simon J., Bateson A.N., Burnstock G., Barnard E.A. Mol. Pharmacol. 50:258-265(1996) [PubMed: 8700132] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Brain.

Cross-references

Sequence databases
EMBLGenBankDDBJ	X98283 mRNA. Translation: CAA66930.1.
RefSeq	NP_990526.1.
UniGene	Gga.660
3D structure databases
HSSP	HSSP built from PDB template 1DDD based on UniProtKB P34996.
ModBase	Search...
Protein family/group databases
GPCRDB	Search...
Genome annotation databases
Ensembl	ENSGALG00000017327. Gallus gallus. [Contig view]
GeneID	396114.
KEGG	gga:396114.
Phylogenomic databases
HOGENOM	Q98907.
HOVERGEN	Q98907.
Family and domain databases
InterPro	IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_supfam. IPR002286. P2_purnocptor. IPR000371. P2Y3_purnocptor. [Graphical view]
Pfam	PF00001. 7tm_1. 1 hit. [Graphical view]
PRINTS	PR00237. GPCRRHODOPSN. PR01065. P2Y3PRNOCPTR. PR01157. P2YPURNOCPTR.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. False negative. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProDom	Q98907. [Graphical view] [Entries sharing at least one domain]
BLOCKS	Search...
Other Resources
ProtoNet	Search...

Entry information

Entry name

P2RY3_CHICK

Accession

Primary (citable) accession number: Q98907

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	February 1, 1997
Last modified:	September 2, 2008
This is version 46 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)