true
1995-02-01
2008-07-22
67
COMP_BACSU
Sensor protein comP
A Bacillus subtilis regulatory gene product for genetic competence and sporulation resembles sensor protein members of the bacterial two-component signal-transduction systems.
Weinrauch Y.
Penchev R.
Dubnau E.
Smith I.
Dubnau D.
1990
Genes Dev.
4
860-872
NUCLEOTIDE SEQUENCE [GENOMIC DNA]
BD630
Analysis of the Bacillus subtilis genome: cloning and nucleotide sequence of a 62 kb region between 275 degrees (rrnB) and 284 degrees (pai).
Oudega B.
Koningstein G.
Rodrigues L.
de Sales Ramon M.
Hilbert H.
Duesterhoeft A.
Pohl T.M.
Weitzenegger T.
1997
Microbiology
143
2769-2774
NUCLEOTIDE SEQUENCE [GENOMIC DNA]
168
The complete genome sequence of the Gram-positive bacterium Bacillus subtilis.
Kunst F.
Ogasawara N.
Moszer I.
Albertini A.M.
Alloni G.
Azevedo V.
Bertero M.G.
Bessieres P.
Bolotin A.
Borchert S.
Borriss R.
Boursier L.
Brans A.
Braun M.
Brignell S.C.
Bron S.
Brouillet S.
Bruschi C.V.
Caldwell B.
Capuano V.
Carter N.M.
Choi S.-K.
Codani J.-J.
Connerton I.F.
Cummings N.J.
Daniel R.A.
Denizot F.
Devine K.M.
Duesterhoeft A.
Ehrlich S.D.
Emmerson P.T.
Entian K.-D.
Errington J.
Fabret C.
Ferrari E.
Foulger D.
Fritz C.
Fujita M.
Fujita Y.
Fuma S.
Galizzi A.
Galleron N.
Ghim S.-Y.
Glaser P.
Goffeau A.
Golightly E.J.
Grandi G.
Guiseppi G.
Guy B.J.
Haga K.
Haiech J.
Harwood C.R.
Henaut A.
Hilbert H.
Holsappel S.
Hosono S.
Hullo M.-F.
Itaya M.
Jones L.-M.
Joris B.
Karamata D.
Kasahara Y.
Klaerr-Blanchard M.
Klein C.
Kobayashi Y.
Koetter P.
Koningstein G.
Krogh S.
Kumano M.
Kurita K.
Lapidus A.
Lardinois S.
Lauber J.
Lazarevic V.
Lee S.-M.
Levine A.
Liu H.
Masuda S.
Mauel C.
Medigue C.
Medina N.
Mellado R.P.
Mizuno M.
Moestl D.
Nakai S.
Noback M.
Noone D.
O'Reilly M.
Ogawa K.
Ogiwara A.
Oudega B.
Park S.-H.
Parro V.
Pohl T.M.
Portetelle D.
Porwollik S.
Prescott A.M.
Presecan E.
Pujic P.
Purnelle B.
Rapoport G.
Rey M.
Reynolds S.
Rieger M.
Rivolta C.
Rocha E.
Roche B.
Rose M.
Sadaie Y.
Sato T.
Scanlan E.
Schleich S.
Schroeter R.
Scoffone F.
Sekiguchi J.
Sekowska A.
Seror S.J.
Serror P.
Shin B.-S.
Soldo B.
Sorokin A.
Tacconi E.
Takagi T.
Takahashi H.
Takemaru K.
Takeuchi M.
Tamakoshi A.
Tanaka T.
Terpstra P.
Tognoni A.
Tosato V.
Uchiyama S.
Vandenbol M.
Vannier F.
Vassarotti A.
Viari A.
Wambutt R.
Wedler E.
Wedler H.
Weitzenegger T.
Winters P.
Wipat A.
Yamamoto H.
Yamane K.
Yasumoto K.
Yata K.
Yoshida K.
Yoshikawa H.-F.
Zumstein E.
Yoshikawa H.
Danchin A.
doi:10.1038/36786
1997
Nature
390
249-256
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
168
Sequence and properties of comQ, a new competence regulatory gene of Bacillus subtilis.
Weinrauch Y.
Msadek T.
Kunst F.
Dubnau D.
1991
J. Bacteriol.
173
5685-5693
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-16
168
Specificity and genetic polymorphism of the Bacillus competence quorum-sensing system.
Tortosa P.
Logsdon L.
Kraigher B.
Itoh Y.
Mandic-Mulec I.
Dubnau D.
doi:10.1128/JB.183.2.451-460.2001
2001
J. Bacteriol.
183
451-460
POLYMORPHISM IN COMX; COMQ AND COMP
Conservation of genes and processes controlled by the quorum response in bacteria: characterization of genes controlled by the quorum-sensing transcription factor ComA in Bacillus subtilis.
Comella N.
Grossman A.D.
doi:10.1111/j.1365-2958.2005.04749.x
2005
Mol. Microbiol.
57
1159-1174
FUNCTION
comP
BSU31690
Sensor in the two-component regulatory system comP/comA involved in a major quorum response pathway that regulates the development of genetic competence. Plays a role in sporulation, at least partly interchangeable with that of spoIIJ.
ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.
Autophosphorylates on a histidine and transfers the phosphate group onto an aspartate in comA, thus activating it.
The DNA sequences encoding comQ, comX and the N-terminal two-thirds of comP show a striking polymorphism, which determines the specificity of the quorum-sensing system in the different pherotypes of Bacillus.
Contains 1 histidine kinase domain.
Sensor protein comP
1
769
Cytoplasmic
1
9
10
33
Extracellular
34
113
114
134
Cytoplasmic
135
144
145
167
Extracellular
168
235
236
257
Cytoplasmic
258
272
273
295
Extracellular
296
299
300
323
Cytoplasmic
324
337
338
357
Extracellular
358
361
362
383
Cytoplasmic
384
769
Histidine kinase
571
769
Phosphohistidine; by autocatalysis
456
456
C
604
604
Y
610
610
G
628
628
PV
636
637
EMBL
EMBL
EMBL
EMBL
EMBL
PIR
PIR
RefSeq
GeneID
GenomeReviews
BSU31690
KEGG
NMPDR
SubtiList
comP
HOGENOM
BioCyc
InterPro
ATP_bd_ATPase
InterPro
Sig_transdc_His_kin_sub3_dim/P
InterPro
Sig_transdc_His_kinase_core
Gene3D
ATP_bd_ATPase
1
Pfam
HATPase_c
1
Pfam
HisKA_3
1
SMART
HATPase_c
1
PROSITE
HIS_KIN
1
UniProtKB-SubCell
2000-05-30
2
89317
MKNLIKKFTI AVIVLSILYI SYTTYISMNG IIIGTKIHKN DKSQFMIEEI SESSYGQFVG LRQADIILKI NKEKPSDKHL KWGYLSHINS LDILRSGKKI HLKDFDLVTL NRPYSFFLFV LPLFFYFLSI ICIFYILKVN KKRRSFAAYI LILLLLDISI AYISAGGPFR GHIINRYINL FTFISSPILY LQFIQRYLGE IGKTFLNRIS FLYIIPIFNL GIEFFQDYLQ VDIDFLATLN LVSFATLTLF SFSAIYLHLN KYKYAEHSFI LKLLILTNTL SFAPFLIFFV LPIIFTGNYI FPALASASLL VLIPFGLVYQ FVANKMFDIE FILGRMRYYA LLAMIPTLLI VGALVLFDVM DIQMNPVRQT VFFFVVMFAV FYFKEVMDFK FRLKRFSEKF NYQDSIFKYT QLMRGVTSLQ QVFKELKNTI LDVLLVSKAY TFEVTPDHKV IFLDKHEVGP DWNFYQEEFE NVTSEIGKII EVNQGFLMKV GERGGSSYVL LCLSNINTPR LTRDEISWLK TLSFYTSVSM ENVLHIEELM EHLKDLKQEG TNPIWLKKLM FAIEEKQRSG LARDLHDSVL QDLISLKRQC ELFLGDFKKD DNPSREEVQD KLVQMNEQMS DVISMTRETC HELRPQLLYD LGLVKALSKL VAHEQERVPF HIRLNTGRFT ASLDLDSQLN LYRIIQEFLS NAVKHSQATD VLIMLISIQN KIVLHYEDDG VGFDQEKNTE HSMSMGLSGI KERVRALDGR LRIETSEGKG FKADIEIEL