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Reviewed, UniProtKB/Swiss-Prot Q99766 (ATP5S_HUMAN)

Last modified July 22, 2008. Version 57. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    ATP synthase subunit s, mitochondrial
Alternative name(s):
    ATP synthase-coupling factor B
    Mitochondrial ATP synthase regulatory component factor B
Gene names
Name: ATP5S
Synonyms: ATPW
OrganismHomo sapiens (Human)
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

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Protein attributes

Sequence length215 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level.

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General annotation (Comments)

Function

Involved in regulation of mitochondrial membrane ATP synthase. Necessary for H(+) conduction of ATP synthase.

Subunit structure

Monomer. Associates with ATP synthase By similarity.

Subcellular location

MitochondrionBy similarity. Mitochondrion inner membraneBy similarity.

Sequence similarities

Belongs to the ATP synthase subunit s family.

Caution

It is uncertain whether Met-1 or Met-16 is the initiator.

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Ontologies

Keywords

   Biological processHydrogen ion transport
Ion transport
Transport
   Cellular componentCF(0)
Membrane
Mitochondrion
Mitochondrion inner membrane
   DomainTransit peptide
   Technical termDirect protein sequencing

Gene Ontology (GO)

   Biological processproton transport

Non-traceable author statement. Source: UniProtKB

   Molecular functionhydrogen ion transmembrane transporter activity

Non-traceable author statement. Source: UniProtKB

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical view

Molecule processing

Transit peptide1 – 4040Mitochondrion
Chain41 – 215175ATP synthase subunit s, mitochondrial

Experimental info

Sequence conflict121 – 13616EGLEH…CKCHY → GNYPIVLLIENADDLQ in AAB50202. Ref.4

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Sequences

Sequence LengthMass (Da)Tools
Q99766-1 [UniParc].

Last modified May 10, 2002. Version 2.
Checksum: F692E8419A82E029

FASTA21524,882
        10         20         30         40         50         60 
MCCAVSEQRL TCADQMMLFG KISQQLCGVK KLPWSCDSRY FWGWLNAVFN KVDYDRIRDV 

        70         80         90        100        110        120 
GPDRAASEWL LRCGAMVRYH GQERWQKDYN HLPTGPLDKY KIQAIDATDS CIMSIGFDHM 

       130        140        150        160        170        180 
EGLEHVEKIR LCKCHYIEDD CLLRLSQLEN LQKTILEMEI ISCGNITDKG IIALRHLRNL 

       190        200        210 
KYLLLSDLPG VREKENLVQA FKTALPSLEL KLQLK

« Hide

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References

« Hide 'large scale' references
[1]"Factor B and the mitochondrial ATP synthase complex."
Belogrudov G.I., Hatefi Y.
J. Biol. Chem. 277:6097-6103(2002) [PubMed: 11744738] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE, SUBUNIT.
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Hippocampus.
[3]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"Large-scale concatenation cDNA sequencing."
Yu W., Andersson B., Worley K.C., Muzny D.M., Ding Y., Liu W., Ricafrente J.Y., Wentland M.A., Lennon G., Gibbs R.A.
Genome Res. 7:353-358(1997) [PubMed: 9110174] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-136.
Tissue: Brain.

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Cross-references

Sequence databases

AY052377 mRNA. Translation: AAL13058.1.
AK290008 mRNA. Translation: BAF82697.1.
CH471078 Genomic DNA. Translation: EAW65722.1.
U79253 mRNA. Translation: AAB50202.1.
UniGeneHs.438489

3D structure databases

ModBaseSearch...

Genome annotation databases

EnsemblENSG00000125375. Homo sapiens. [Contig view]
KEGGhsa:27109.

Organism-specific databases

H-InvDBHIX0011641.
HGNCHGNC:18799. ATP5S.
PharmGKBPA134991095.
GenAtlasSearch...
GeneCardsSearch...

Phylogenomic databases

HOVERGENQ99766.

Gene expression databases

ArrayExpressQ99766.
CleanExHS_ATP5S.
GermOnlineENSG00000125375. Homo sapiens.

Family and domain databases

ProDomQ99766.
[Graphical view] [Entries sharing at least one domain]
BLOCKSSearch...

Other Resources

ProtoNetSearch...

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Entry information

Entry nameATP5S_HUMAN
AccessionPrimary (citable) accession number: Q99766
Secondary accession number(s): A8K1U3, Q8WWX3
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 10, 2002
Last modified: July 22, 2008
This is version 57 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

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Relevant documents

Human chromosome 14

Human chromosome 14: entries, gene names and cross-references to MIM

UniProtKB secondary accession numbers

Index of UniProtKB secondary accession numbers

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents