true
2004-04-13
2008-07-22
56
ABEC3_MOUSE
ABM3_MOUSE
DNA dC->dU-editing enzyme APOBEC-3
Apolipoprotein B mRNA-editing complex 3
Arp3
CEM-15
CEM15
The transcriptional landscape of the mammalian genome.
Carninci P.
Kasukawa T.
Katayama S.
Gough J.
Frith M.C.
Maeda N.
Oyama R.
Ravasi T.
Lenhard B.
Wells C.
Kodzius R.
Shimokawa K.
Bajic V.B.
Brenner S.E.
Batalov S.
Forrest A.R.
Zavolan M.
Davis M.J.
Wilming L.G.
Aidinis V.
Allen J.E.
Ambesi-Impiombato A.
Apweiler R.
Aturaliya R.N.
Bailey T.L.
Bansal M.
Baxter L.
Beisel K.W.
Bersano T.
Bono H.
Chalk A.M.
Chiu K.P.
Choudhary V.
Christoffels A.
Clutterbuck D.R.
Crowe M.L.
Dalla E.
Dalrymple B.P.
de Bono B.
Della Gatta G.
di Bernardo D.
Down T.
Engstrom P.
Fagiolini M.
Faulkner G.
Fletcher C.F.
Fukushima T.
Furuno M.
Futaki S.
Gariboldi M.
Georgii-Hemming P.
Gingeras T.R.
Gojobori T.
Green R.E.
Gustincich S.
Harbers M.
Hayashi Y.
Hensch T.K.
Hirokawa N.
Hill D.
Huminiecki L.
Iacono M.
Ikeo K.
Iwama A.
Ishikawa T.
Jakt M.
Kanapin A.
Katoh M.
Kawasawa Y.
Kelso J.
Kitamura H.
Kitano H.
Kollias G.
Krishnan S.P.
Kruger A.
Kummerfeld S.K.
Kurochkin I.V.
Lareau L.F.
Lazarevic D.
Lipovich L.
Liu J.
Liuni S.
McWilliam S.
Madan Babu M.
Madera M.
Marchionni L.
Matsuda H.
Matsuzawa S.
Miki H.
Mignone F.
Miyake S.
Morris K.
Mottagui-Tabar S.
Mulder N.
Nakano N.
Nakauchi H.
Ng P.
Nilsson R.
Nishiguchi S.
Nishikawa S.
Nori F.
Ohara O.
Okazaki Y.
Orlando V.
Pang K.C.
Pavan W.J.
Pavesi G.
Pesole G.
Petrovsky N.
Piazza S.
Reed J.
Reid J.F.
Ring B.Z.
Ringwald M.
Rost B.
Ruan Y.
Salzberg S.L.
Sandelin A.
Schneider C.
Schoenbach C.
Sekiguchi K.
Semple C.A.
Seno S.
Sessa L.
Sheng Y.
Shibata Y.
Shimada H.
Shimada K.
Silva D.
Sinclair B.
Sperling S.
Stupka E.
Sugiura K.
Sultana R.
Takenaka Y.
Taki K.
Tammoja K.
Tan S.L.
Tang S.
Taylor M.S.
Tegner J.
Teichmann S.A.
Ueda H.R.
van Nimwegen E.
Verardo R.
Wei C.L.
Yagi K.
Yamanishi H.
Zabarovsky E.
Zhu S.
Zimmer A.
Hide W.
Bult C.
Grimmond S.M.
Teasdale R.D.
Liu E.T.
Brusic V.
Quackenbush J.
Wahlestedt C.
Mattick J.S.
Hume D.A.
Kai C.
Sasaki D.
Tomaru Y.
Fukuda S.
Kanamori-Katayama M.
Suzuki M.
Aoki J.
Arakawa T.
Iida J.
Imamura K.
Itoh M.
Kato T.
Kawaji H.
Kawagashira N.
Kawashima T.
Kojima M.
Kondo S.
Konno H.
Nakano K.
Ninomiya N.
Nishio T.
Okada M.
Plessy C.
Shibata K.
Shiraki T.
Suzuki S.
Tagami M.
Waki K.
Watahiki A.
Okamura-Oho Y.
Suzuki H.
Kawai J.
Hayashizaki Y.
doi:10.1126/science.1112014
2005
Science
309
1559-1563
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3)
VARIANTS ARG-34; 37-ILE-ASP-38; 112-VAL-LEU-113; 134-ILE-ARG-135; ASN-139; LYS-181; 233-VAL-HIS-LEU-235; GLY-258; ILE-306 AND HIS-404
C57BL/6J
Hippocampus
Retina
Mariani R.
Landau N.R.
2004-02
UniProtKB
NUCLEOTIDE SEQUENCE (ISOFORM 4)
VARIANTS
C57BL/6J
Spleen
Initial sequencing and comparative analysis of the mouse genome.
Waterston R.H.
Lindblad-Toh K.
Birney E.
Rogers J.
Abril J.F.
Agarwal P.
Agarwala R.
Ainscough R.
Alexandersson M.
An P.
Antonarakis S.E.
Attwood J.
Baertsch R.
Bailey J.
Barlow K.
Beck S.
Berry E.
Birren B.
Bloom T.
Bork P.
Botcherby M.
Bray N.
Brent M.R.
Brown D.G.
Brown S.D.
Bult C.
Burton J.
Butler J.
Campbell R.D.
Carninci P.
Cawley S.
Chiaromonte F.
Chinwalla A.T.
Church D.M.
Clamp M.
Clee C.
Collins F.S.
Cook L.L.
Copley R.R.
Coulson A.
Couronne O.
Cuff J.
Curwen V.
Cutts T.
Daly M.
David R.
Davies J.
Delehaunty K.D.
Deri J.
Dermitzakis E.T.
Dewey C.
Dickens N.J.
Diekhans M.
Dodge S.
Dubchak I.
Dunn D.M.
Eddy S.R.
Elnitski L.
Emes R.D.
Eswara P.
Eyras E.
Felsenfeld A.
Fewell G.A.
Flicek P.
Foley K.
Frankel W.N.
Fulton L.A.
Fulton R.S.
Furey T.S.
Gage D.
Gibbs R.A.
Glusman G.
Gnerre S.
Goldman N.
Goodstadt L.
Grafham D.
Graves T.A.
Green E.D.
Gregory S.
Guigo R.
Guyer M.
Hardison R.C.
Haussler D.
Hayashizaki Y.
Hillier L.W.
Hinrichs A.
Hlavina W.
Holzer T.
Hsu F.
Hua A.
Hubbard T.
Hunt A.
Jackson I.
Jaffe D.B.
Johnson L.S.
Jones M.
Jones T.A.
Joy A.
Kamal M.
Karlsson E.K.
Karolchik D.
Kasprzyk A.
Kawai J.
Keibler E.
Kells C.
Kent W.J.
Kirby A.
Kolbe D.L.
Korf I.
Kucherlapati R.S.
Kulbokas E.J.
Kulp D.
Landers T.
Leger J.P.
Leonard S.
Letunic I.
Levine R.
Li J.
Li M.
Lloyd C.
Lucas S.
Ma B.
Maglott D.R.
Mardis E.R.
Matthews L.
Mauceli E.
Mayer J.H.
McCarthy M.
McCombie W.R.
McLaren S.
McLay K.
McPherson J.D.
Meldrim J.
Meredith B.
Mesirov J.P.
Miller W.
Miner T.L.
Mongin E.
Montgomery K.T.
Morgan M.
Mott R.
Mullikin J.C.
Muzny D.M.
Nash W.E.
Nelson J.O.
Nhan M.N.
Nicol R.
Ning Z.
Nusbaum C.
O'Connor M.J.
Okazaki Y.
Oliver K.
Overton-Larty E.
Pachter L.
Parra G.
Pepin K.H.
Peterson J.
Pevzner P.
Plumb R.
Pohl C.S.
Poliakov A.
Ponce T.C.
Ponting C.P.
Potter S.
Quail M.
Reymond A.
Roe B.A.
Roskin K.M.
Rubin E.M.
Rust A.G.
Santos R.
Sapojnikov V.
Schultz B.
Schultz J.
Schwartz M.S.
Schwartz S.
Scott C.
Seaman S.
Searle S.
Sharpe T.
Sheridan A.
Shownkeen R.
Sims S.
Singer J.B.
Slater G.
Smit A.
Smith D.R.
Spencer B.
Stabenau A.
Stange-Thomann N.
Sugnet C.
Suyama M.
Tesler G.
Thompson J.
Torrents D.
Trevaskis E.
Tromp J.
Ucla C.
Ureta-Vidal A.
Vinson J.P.
Von Niederhausern A.C.
Wade C.M.
Wall M.
Weber R.J.
Weiss R.B.
Wendl M.C.
West A.P.
Wetterstrand K.
Wheeler R.
Whelan S.
Wierzbowski J.
Willey D.
Williams S.
Wilson R.K.
Winter E.
Worley K.C.
Wyman D.
Yang S.
Yang S.P.
Zdobnov E.M.
Zody M.C.
Lander E.S.
doi:10.1038/nature01262
2002
Nature
420
520-562
NUCLEOTIDE SEQUENCE
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
The MGC Project Team
doi:10.1101/gr.2596504
2004
Genome Res.
14
2121-2127
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
VARIANTS ARG-34; 37-ILE-ASP-38; 112-VAL-LEU-113; 134-ILE-ARG-135; ASN-139; LYS-181; 233-VAL-HIS-LEU-235; GLY-258; ILE-306 AND HIS-404
Mammary tumor
Species-specific exclusion of APOBEC3G from HIV-1 virions by Vif.
Mariani R.
Chen D.
Schroefelbauer B.
Navarro F.
Koenig R.
Bollman B.
Muenk C.
Nymark-McMahon H.
Landau N.R.
doi:10.1016/S0092-8674(03)00515-4
2003
Cell
114
21-31
DNA C TO U EDITING ACTIVITY
TISSUE SPECIFICITY
Apobec3
Probable human APOBEC3G ortholog. Has DNA deaminase (cytidine deaminase) activity. Mediates G-to-A hypermutation in newly synthesized HIV-1 viral DNA and is thus able to prevent HIV-1 infectivity in vitro, in the presence and absence of HIV-1 VIF (virion infectivity factor).
Zinc (By similarity).
Mainly cytoplasmic, small amount are found in the nucleus (By similarity).
Expressed in spleen, node and lung.
Polymorphism seems to be an important factor for the ability of the protein to prevent HIV-1 infectivity in vitro. The protein derived from MDTF and EL4 cell lines are unable to reduce HIV-1 infectivity, while the protein derived from L1.2, 3T3 and splenocytes are able to do it, in the presence and absence of HIV-1 VIF (virion infectivity factor).
HIV-1 VIF (virion infectivity factor) does not bind to mouse APOBEC3.
Belongs to the cytidine and deoxycytidylate deaminase family.
DNA dC->dU-editing enzyme APOBEC-3
1
429
Proton donor
73
73
Zinc
71
71
Zinc
105
105
Zinc
108
108
Zinc
288
288
Zinc
316
316
Zinc
319
319
In isoform 3 and isoform 4.
198
230
In isoform 2.
VRTTLLQGPAS
409
429
In isoform 3.
SRSHAS
409
429
In cell line MDTF.
V
20
20
In cell line MDTF.
E
31
31
In cell line MDTF.
PF
34
35
In cell lines L1.2 and 3T3.
R
34
34
In cell lines L1.2 and 3T3.
ID
37
38
In cell line MDTF.
K
38
38
In cell line L1.2.
R
111
111
In cell lines L1.2 and 3T3.
VL
112
113
In cell line MDTF.
V
112
112
In cell line MDTF.
F
128
128
In cell line MDTF.
IRNPEN
134
139
In cell lines L1.2 and 3T3.
IR
134
135
In cell line 3T3.
NQL
139
140
In cell line L1.2.
N
139
139
In cell line MDTF.
L
148
148
In cell line MDTF.
EE
162
163
In cell lines L1.2 and 3T3.
K
181
181
In cell line MDTF.
198
230
In cell line 3T3.
RRRVHL
230
235
VHL
233
235
In cell line MDTF.
SL
234
235
In cell line MDTF.
L
248
248
In cell line 3T3.
GV
258
259
In cell line L1.2.
G
258
258
In cell line MDTF.
F
264
264
In cell line MDTF.
W
269
269
In cell line MDTF.
E
274
274
In cell line MDTF.
284
296
In cell lines L1.2 and 3T3.
I
306
306
In cell line EL4.
G
314
314
In cell line MDTF.
K
328
328
In cell line MDTF.
S
381
381
In splenocytes.
R
387
387
In cell line MDTF.
KT
394
395
In cell line L1.2.
A
399
399
In cell lines MDTF and 3T3.
C
404
404
In cell line L1.2.
H
404
404
S
203
203
W
227
227
R
230
230
RSHAS
410
414
Lacks exon V. Also active in inhibiting HIV-1 in vitro.
EMBL
EMBL
EMBL
EMBL
UniGene
UniGene
Ensembl
Mus musculus
MGI
Apobec3
HOGENOM
HOVERGEN
ArrayExpress
CleanEx
GermOnline
Mus musculus
InterPro
APOBEC/CMP_deaminase_Zn-bd
InterPro
APOBEC_C
InterPro
APOBEC_N
Pfam
APOBEC_C
2
Pfam
APOBEC_N
2
PROSITE
CYT_DCMP_DEAMINASES
2
2004-04-13
2
50948
1
MGPFCLGCSH RKCYSPIRNL ISQETFKFHF KNLGYAKGRK DTFLCYEVTR KDCDSPVSLH HGVFKNKDNI HAEICFLYWF HDKVLKVLSP REEFKITWYM SWSPCFECAE QIVRFLATHH NLSLDIFSSR LYNVQDPETQ QNLCRLVQEG AQVAAMDLYE FKKCWKKFVD NGGRRFRPWK RLLTNFRYQD SKLQEILRPC YIPVPSSSSS TLSNICLTKG LPETRFCVEG RRMDPLSEEE FYSQFYNQRV KHLCYYHRMK PYLCYQLEQF NGQAPLKGCL LSEKGKQHAE ILFLDKIRSM ELSQVTITCY LTWSPCPNCA WQLAAFKRDR PDLILHIYTS RLYFHWKRPF QKGLCSLWQS GILVDVMDLP QFTDCWTNFV NPKRPFWPWK GLEIISRRTQ RRLRRIKESW GLQDLVNDFG NLQLGPPMS
2
3
4