Reviewed, UniProtKB/Swiss-Prot Q9BSU3 (ARD1B_HUMAN)

Names and origin

Protein names

Recommended name:
    N-terminal acetyltransferase complex ARD1 subunit homolog B
      Short name=hARD2
    EC=2.3.1.88

Gene names

Name:	ARD1B
Synonyms:	ARD2

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	229 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	In complex with NARG1, displays alpha (N-terminal) acetyltransferase activity.
Catalytic activity	Acetyl-CoA + peptide = N(alpha)-acetylpeptide + CoA.
Subunit structure	Interacts with NARG1 and HIF1A.
Subcellular location	Cytoplasm. Nucleus.
Tissue specificity	Present in several cell lines, with highest levels in MCF-7 cells (at protein level).
Sequence similarities	Belongs to the acetyltransferase family. ARD1 subfamily. Contains 1 N-acetyltransferase domain.

Ontologies

Keywords
Cellular component	Cytoplasm Nucleus
Molecular function	Acyltransferase Transferase
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view
Molecule processing
	Chain	1 – 229	229	N-terminal acetyltransferase complex ARD1 subunit homolog B
Regions
	Domain	1 – 152	152	N-acetyltransferase
	Region	1 – 58	58	Interaction with NARG1 By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9BSU3-1 [UniParc]. Last modified October 2, 2007. Version 3. Checksum: F547D816A1E07ACE	FASTA	229	25,979
	10 20 30 40 50 60 MNIRNAQPDD LMNMQHCNLL CLPENYQMKY YLYHGLSWPQ LSYIAEDEDG KIVGYVLAKM 70 80 90 100 110 120 EEEPDDVPHG HITSLAVKRS HRRLGLAQKL MDQASRAMIE NFNAKYVSLH VRKSNRPALH 130 140 150 160 170 180 LYSNTLNFQI SEVEPKYYAD GEDAYAMKRD LSQMADELRR QMDLKKGGYV VLGSRENQET 190 200 210 220 QGSTLSDSEE ACQQKNPATE ESGSDSKEPK ESVESTNVQD SSESSDSTS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Skin.
[2]	"Characterization of hARD2, a processed hARD1 gene duplicate, encoding a human protein N-alpha-acetyltransferase." Arnesen T., Betts M.J., Pendino F., Liberles D.A., Anderson D., Caro J., Kong X., Varhaug J.E., Lillehaug J.R. BMC Biochem. 7:13-13(2006) [PubMed: 16638120] [Abstract] Cited for: FUNCTION, INTERACTION WITH NARG1 AND HIF1A, TISSUE SPECIFICITY, SUBCELLULAR LOCATION.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BC004552 mRNA. Translation: AAH04552.2. Different initiation. BC063623 mRNA. Translation: AAH63623.1. Different initiation. BC080651 mRNA. Translation: AAH80651.1. Different initiation.
RefSeq	NP_116082.1.
UniGene	Hs.676048
3D structure databases
ModBase	Search...
Genome annotation databases
Ensembl	ENSG00000156269. Homo sapiens. [Contig view]
GeneID	84779.
KEGG	hsa:84779.
Organism-specific databases
HGNC	HGNC:28125. ARD1B.
PharmGKB	PA142672595.
GenAtlas	Search...
GeneCards	Search...
Phylogenomic databases
HOGENOM	Q9BSU3.
HOVERGEN	Q9BSU3.
Gene expression databases
ArrayExpress	Q9BSU3.
CleanEx	HS_ARD1B.
Family and domain databases
InterPro	IPR016181. Acyl_CoA_acyltransferase. IPR000182. GCN5-rel_AcTrfase. [Graphical view]
Gene3D	G3DSA:3.40.630.30. Acyl_CoA_acyltransferase. 1 hit.
Pfam	PF00583. Acetyltransf_1. 1 hit. [Graphical view]
PROSITE	PS51186. GNAT. 1 hit. [Graphical view]
ProDom	Q9BSU3. [Graphical view] [Entries sharing at least one domain]
BLOCKS	Search...
Other Resources
ProtoNet	Search...

Entry information

Entry name

ARD1B_HUMAN

Accession

Primary (citable) accession number: Q9BSU3
Secondary accession number(s): Q66K19, Q6P479

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 2, 2007
Last sequence update:	October 2, 2007
Last modified:	September 2, 2008
This is version 40 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)