Reviewed, UniProtKB/Swiss-Prot Q9BX70 (BTBD2_HUMAN)

Names and origin

Protein names

Recommended name:
    BTB/POZ domain-containing protein 2

Gene names

Name:

BTBD2

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	525 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Subunit structure	Interacts with topoisomerase 1 and with TRIM5 isoform Delta.
Subcellular location	Cytoplasm › P-body. Note= Cytoplasmic bodies.
Sequence similarities	Contains 1 BTB (POZ) domain.
Sequence caution	The sequence AAC16070.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
Cellular component	Cytoplasm
Coding sequence diversity	Alternative splicing
Gene Ontology (GO)
Molecular function	protein binding Inferred from physical interaction. Source: IntAct
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
E2	P03120	2	EBI-710091,EBI-1779322	From a different organism.
TP53	P04637	1	EBI-710091,EBI-366083

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9BX70-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9BX70-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-321: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view
Molecule processing
	Chain	1 – 525	525	BTB/POZ domain-containing protein 2
Regions
	Domain	117 – 187	71	BTB
	Compositional bias	41 – 54	14	Poly-Ala
Natural variations
	Alternative sequence	1 – 321	321	Missing in isoform 2.
Experimental info
	Sequence conflict	307	1	R → L in CAB96527. Ref.6

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified June 1, 2001. Version 1. Checksum: 5F4856161702A65D	FASTA	525	55,931
	10 20 30 40 50 60 MAAGGSGGRA SCPPGVGVGP GTGGSPGPSA NAAATPAPGN AAAAAAAAAA AAAAPGPTPP 70 80 90 100 110 120 APPGPGTDAQ AAGAERAEEA AGPGAAALQR EAAYNWQASK PTVQERFAFL FNNEVLCDVH 130 140 150 160 170 180 FLVGKGLSSQ RIPAHRFVLA VGSAVFDAMF NGGMATTSTE IELPDVEPAA FLALLKFLYS 190 200 210 220 230 240 DEVQIGPETV MTTLYTAKKY AVPALEAHCV EFLKKNLRAD NAFMLLTQAR LFDEPQLASL 250 260 270 280 290 300 CLENIDKNTA DAITAEGFTD IDLDTLVAVL ERDTLGIREV RLFNAVVRWS EAECQRQQLQ 310 320 330 340 350 360 VTPENRRKVL GKALGLIRFP LMTIEEFAAG PAQSGILVDR EVVSLFLHFT VNPKPRVEFI 370 380 390 400 410 420 DRPRCCLRGK ECSINRFQQV ESRWGYSGTS DRIRFSVNKR IFVVGFGLYG SIHGPTDYQV 430 440 450 460 470 480 NIQIIHTDSN TVLGQNDTGF SCDGSASTFR VMFKEPVEVL PNVNYTACAT LKGPDSHYGT 490 500 510 520 KGLRKVTHES PTTGAKTCFT FCYAAGNNNG TSVEDGQIPE VIFYT
	Isoform 2 [UniParc]. Checksum: 08727FE5DF916D4C		204	22,566
	10 20 30 40 50 60 MTIEEFAAGP AQSGILVDRE VVSLFLHFTV NPKPRVEFID RPRCCLRGKE CSINRFQQVE 70 80 90 100 110 120 SRWGYSGTSD RIRFSVNKRI FVVGFGLYGS IHGPTDYQVN IQIIHTDSNT VLGQNDTGFS 130 140 150 160 170 180 CDGSASTFRV MFKEPVEVLP NVNYTACATL KGPDSHYGTK GLRKVTHESP TTGAKTCFTF 190 200 CYAAGNNNGT SVEDGQIPEV IFYT

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Characterization of BTBD1 and BTBD2, two similar BTB-domain-containing Kelch-like proteins that interact with topoisomerase I." Xu L., Yang L., Hashimoto K., Anderson M., Kohlhagen G., Pommier Y., D'Arpa P. BMC Genomics 3:1-1(2002) [PubMed: 11818025] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 214-525 (ISOFORM 1). Tissue: Teratocarcinoma.
[3]	"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)." Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B. Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
[4]	"The DNA sequence and biology of human chromosome 19." Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V. , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M. Nature 428:529-535(2004) [PubMed: 15057824] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 90-525 (ISOFORM 1). Tissue: Blood, Brain, Colon and Ovary.
[6]	The European IMAGE consortium Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 258-525 (ISOFORM 1).
[7]	"BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta." Xu L., Yang L., Moitra P.K., Hashimoto K., Rallabhandi P., Kaul S., Meroni G., Jensen J.P., Weissman A.M., D'Arpa P. Exp. Cell Res. 288:84-93(2003) [PubMed: 12878161] [Abstract] Cited for: SUBCELLULAR LOCATION, INTERACTION WITH TRIM5.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF355797 mRNA. Translation: AAK25826.1. AK000393 mRNA. Translation: BAA91136.1. AK027481 mRNA. Translation: BAB55143.1. Different initiation. CR457230 mRNA. Translation: CAG33511.1. AC004678 Genomic DNA. Translation: AAC16070.1. Sequence problems. AC005306 Genomic DNA. Translation: AAC26984.1. AC005306 Genomic DNA. Translation: AAG45443.1. BC000564 mRNA. Translation: AAH00564.2. BC008035 mRNA. Translation: AAH08035.2. BC053986 mRNA. Translation: AAH53986.1. BC094820 mRNA. Translation: AAH94820.1. AL360275 mRNA. Translation: CAB96527.1.
RefSeq	NP_060267.2.
UniGene	Hs.465543
3D structure databases
HSSP	HSSP built from PDB template 1BUO based on UniProtKB Q05516.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9BX70.
Genome annotation databases
Ensembl	ENSG00000133243. Homo sapiens. [Contig view]
GeneID	55643.
KEGG	hsa:55643.
Organism-specific databases
H-InvDB	HIX0014603. HIX0040331.
HGNC	HGNC:15504. BTBD2.
MIM	608531. gene.
PharmGKB	PA25439.
GenAtlas	Search...
GeneCards	Search...
Phylogenomic databases
HOVERGEN	Q9BX70.
Gene expression databases
ArrayExpress	Q9BX70.
GermOnline	ENSG00000133243. Homo sapiens.
Family and domain databases
InterPro	IPR011705. BACK. IPR000210. BTB/POZ-like. IPR011333. BTB/POZ_fold. IPR013069. BTB_POZ. IPR013089. Kelch_related. IPR012983. PHR. [Graphical view]
Gene3D	G3DSA:3.30.710.10. BTB/POZ_fold. 1 hit.
PANTHER	PTHR23230. Kelch_related. 1 hit.
Pfam	PF07707. BACK. 1 hit. PF00651. BTB. 1 hit. PF08005. PHR. 1 hit. [Graphical view]
SMART	SM00225. BTB. 1 hit. [Graphical view]
PROSITE	PS50097. BTB. 1 hit. [Graphical view]
ProDom	Q9BX70. [Graphical view] [Entries sharing at least one domain]
BLOCKS	Search...
Other Resources
SOURCE	Search...
ProtoNet	Search...

Entry information

Entry name

BTBD2_HUMAN

Accession

Primary (citable) accession number: Q9BX70
Secondary accession number(s): O60418 , O75248, Q4VBZ1, Q6IAC5, Q7Z5W0, Q96SX8, Q9NPS1, Q9NX81

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 23, 2002
Last sequence update:	June 1, 2001
Last modified:	September 2, 2008
This is version 60 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)