true
2007-05-01
2008-07-22
26
FATSO_HUMAN
Protein fatso
Fat mass and obesity-associated protein
Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.
Nagase T.
Kikuno R.
Hattori A.
Kondo Y.
Okumura K.
Ohara O.
doi:10.1093/dnares/7.6.347
2000
DNA Res.
7
347-355
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
Brain
The sequence and analysis of duplication-rich human chromosome 16.
Martin J.
Han C.
Gordon L.A.
Terry A.
Prabhakar S.
She X.
Xie G.
Hellsten U.
Chan Y.M.
Altherr M.
Couronne O.
Aerts A.
Bajorek E.
Black S.
Blumer H.
Branscomb E.
Brown N.C.
Bruno W.J.
Buckingham J.M.
Callen D.F.
Campbell C.S.
Campbell M.L.
Campbell E.W.
Caoile C.
Challacombe J.F.
Chasteen L.A.
Chertkov O.
Chi H.C.
Christensen M.
Clark L.M.
Cohn J.D.
Denys M.
Detter J.C.
Dickson M.
Dimitrijevic-Bussod M.
Escobar J.
Fawcett J.J.
Flowers D.
Fotopulos D.
Glavina T.
Gomez M.
Gonzales E.
Goodstein D.
Goodwin L.A.
Grady D.L.
Grigoriev I.
Groza M.
Hammon N.
Hawkins T.
Haydu L.
Hildebrand C.E.
Huang W.
Israni S.
Jett J.
Jewett P.B.
Kadner K.
Kimball H.
Kobayashi A.
Krawczyk M.-C.
Leyba T.
Longmire J.L.
Lopez F.
Lou Y.
Lowry S.
Ludeman T.
Manohar C.F.
Mark G.A.
McMurray K.L.
Meincke L.J.
Morgan J.
Moyzis R.K.
Mundt M.O.
Munk A.C.
Nandkeshwar R.D.
Pitluck S.
Pollard M.
Predki P.
Parson-Quintana B.
Ramirez L.
Rash S.
Retterer J.
Ricke D.O.
Robinson D.L.
Rodriguez A.
Salamov A.
Saunders E.H.
Scott D.
Shough T.
Stallings R.L.
Stalvey M.
Sutherland R.D.
Tapia R.
Tesmer J.G.
Thayer N.
Thompson L.S.
Tice H.
Torney D.C.
Tran-Gyamfi M.
Tsai M.
Ulanovsky L.E.
Ustaszewska A.
Vo N.
White P.S.
Williams A.L.
Wills P.L.
Wu J.-R.
Wu K.
Yang J.
DeJong P.
Bruce D.
Doggett N.A.
Deaven L.
Schmutz J.
Grimwood J.
Richardson P.
Rokhsar D.S.
Eichler E.E.
Gilna P.
Lucas S.M.
Myers R.M.
Rubin E.M.
Pennacchio L.A.
doi:10.1038/nature03187
2004
Nature
432
988-994
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
Brain
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
The MGC Project Team
doi:10.1101/gr.2596504
2004
Genome Res.
14
2121-2127
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2; 3 AND 4)
Cervix
Eye
Lung
Variation in FTO contributes to childhood obesity and severe adult obesity.
Dina C.
Meyre D.
Gallina S.
Durand E.
Korner A.
Jacobson P.
Carlsson L.M.S.
Kiess W.
Vatin V.
Lecoeur C.
Delplanque J.
Vaillant E.
Pattou F.
Ruiz J.
Weill J.
Levy-Marchal C.
Horber F.
Potoczna N.
Hercberg S.
Le Stunff C.
Bougneres P.
Kovacs P.
Marre M.
Balkau B.
Cauchi S.
Chevre J.-C.
Froguel P.
doi:10.1038/ng2048
2007
Nat. Genet.
39
724-726
INVOLVEMENT IN PREDISPOSITION OF OBESITY
TISSUE SPECIFICITY
A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity.
Frayling T.M.
Timpson N.J.
Weedon M.N.
Zeggini E.
Freathy R.M.
Lindgren C.M.
Perry J.R.
Elliott K.S.
Lango H.
Rayner N.W.
Shields B.
Harries L.W.
Barrett J.C.
Ellard S.
Groves C.J.
Knight B.
Patch A.M.
Ness A.R.
Ebrahim S.
Lawlor D.A.
Ring S.M.
Ben-Shlomo Y.
Jarvelin M.-R.
Sovio U.
Bennett A.J.
Melzer D.
Ferrucci L.
Loos R.J.
Barroso I.
Wareham N.J.
Karpe F.
Owen K.R.
Cardon L.R.
Walker M.
Hitman G.A.
Palmer C.N.
Doney A.S.
Morris A.D.
Davey-Smith G.
Hattersley A.T.
McCarthy M.I.
doi:10.1126/science.1141634
2007
Science
316
889-894
INVOLVEMENT IN PREDISPOSITION OF OBESITY
TISSUE SPECIFICITY
FTO
KIAA1752
The precise function of this protein remains to be determined.
Ubiquitously expressed, with relatively high expression in adrenal glands and brain; especially in hypothalamus and pituitary.
At least one intronic variation within the gene predisposes to childhood and adult obesity.
This protein was called 'Fatso' (Fto) due to the large size of its gene.
Belongs to the fatso family.
Protein fatso
1
505
In isoform 3.
1
445
In isoform 4.
1
399
In isoform 2.
1
378
In isoform 2.
MEWRKVSECNSVEPCREVKKWPYRCIHHGKNFSRM
379
413
In isoform 3.
MACQGREECW
446
455
V
405
405
W
316
316
W
316
316
No experimental confirmation available.
No experimental confirmation available.
No experimental confirmation available.
EMBL
Different initiation.
EMBL
EMBL
EMBL
EMBL
EMBL
EMBL
RefSeq
UniGene
Ensembl
Homo sapiens
GeneID
KEGG
NMPDR
HGNC
FTO
HPA
MIM
gene
HOVERGEN
ArrayExpress
CleanEx
HGNC
HGNC
2007-05-29
3
58282
1
MKRTPTAEER EREAKKLRLL EELEDTWLPY LTPKDDEFYQ QWQLKYPKLI LREASSVSEE LHKEVQEAFL TLHKHGCLFR DLVRIQGKDL LTPVSRILIG NPGCTYKYLN TRLFTVPWPV KGSNIKHTEA EIAAACETFL KLNDYLQIET IQALEELAAK EKANEDAVPL CMSADFPRVG MGSSYNGQDE VDIKSRAAYN VTLLNFMDPQ KMPYLKEEPY FGMGKMAVSW HHDENLVDRS AVAVYSYSCE GPEEESEDDS HLEGRDPDIW HVGFKISWDI ETPGLAIPLH QGDCYFMLDD LNATHQHCVL AGSQPRFSST HRVAECSTGT LDYILQRCQL ALQNVCDDVD NDDVSLKSFE PAVLKQGEEI HNEVEFEWLR QFWFQGNRYR KCTDWWCQPM AQLEALWKKM EGVTNAVLHE VKREGLPVEQ RNEILTAILA SLTARQNLRR EWHARCQSRI ARTLPADQKP ECRPYWEKDD ASMPLPFDLT DIVSELRGQL LEAKP
2
3
4