Reviewed, UniProtKB/Swiss-Prot Q9CR46 (SKA2_MOUSE)

Names and origin

Protein names

Recommended name:
    Spindle and kinetochore-associated protein 2
Alternative name(s):
    Protein FAM33A

Gene names

Name:	Fam33a
Synonyms:	Ska2

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

Protein attributes

Sequence length	120 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Required for timely anaphase onset during mitosis, when chromosomes undergo bipolar attachment on spindle microtubules leading to silencing of the spindle checkpoint. Involved in the maintenance of the metaphase plate and/or spindle checkpoint silencing. Required for SKA1 localization By similarity.
Subunit structure	Interacts directly and forms a complex with SKA1 By similarity.
Subcellular location	SpindleBy similarity. KinetochoreBy similarity. Note= Localizes to both the mitotic spindle and mitotic spindle and kinetochore-associated proteins By similarity.
Sequence similarities	Belongs to the SKA2 family.

Ontologies

Keywords
Biological process	Cell cycle Cell division Mitosis
Cellular component	Kinetochore
Gene Ontology (GO)
Cellular component	condensed chromosome kinetochore Inferred from electronic annotation. Source: UniProtKB-SubCell spindle Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view
Molecule processing
	Chain	1 – 120	120	Spindle and kinetochore-associated protein 2

Sequences

	Sequence		Length	Mass (Da)
	Q9CR46-1 [UniParc]. Last modified June 1, 2001. Version 1. Checksum: 233FE4303B84C117	FASTA	120	13,725
	10 20 30 40 50 60 MEAEVDKLEL MFQKADSDLD YLQYRLEYEV KTNHPHSAGE KNAVTVLKEL SAIKSRYQAL 70 80 90 100 110 120 CARFKAVSVE QKETKSCICA TLNKTMTMIQ ELQKQTNLEL TLLTEEEKAA TEPLKSHMPD

References

[1]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6J. Tissue: Bone.
[2]	The mouse genome sequencing consortium Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C57BL/6J.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AK003196 mRNA. Translation: BAB22634.1. AK013317 mRNA. Translation: BAB28787.1. AK013370 mRNA. Translation: BAB28814.1. AK017811 mRNA. Translation: BAB30948.1. AK162628 mRNA. Translation: BAE36998.1. AL713917 Genomic DNA. Translation: CAI25315.1. BC117001 mRNA. Translation: AAI17002.1. BC119167 mRNA. Translation: AAI19168.1.
RefSeq	NP_079653.1.
UniGene	Mm.45008
3D structure databases
ModBase	Search...
Genome annotation databases
Ensembl	ENSMUSG00000020492. Mus musculus. [Contig view]
GeneID	66140.
KEGG	mmu:66140.
Organism-specific databases
MGI	MGI:1913390. 1110001A07Rik.
Phylogenomic databases
HOVERGEN	Q9CR46.
Gene expression databases
ArrayExpress	Q9CR46.
CleanEx	MM_1110001A07RIK.
Family and domain databases
ProDom	Q9CR46. [Graphical view] [Entries sharing at least one domain]
BLOCKS	Search...
Other Resources
SOURCE	Search...
ProtoNet	Search...

Entry information

Entry name

SKA2_MOUSE

Accession

Primary (citable) accession number: Q9CR46

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 23, 2007
Last sequence update:	June 1, 2001
Last modified:	July 22, 2008
This is version 39 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)